You are here
Dr Vince Russo
Dr Vincenzo Russo is a biologist by training. He originally worked in Italian academic institutions including the University of Padua and National Cancer Institute, Aviano, Italy, where he specialised in protein biochemistry and molecular biology.
Dr Russo then transferred to the Murdoch Childrens Research Institute in Melbourne to undertake a research doctorate in neuroendocrinology and brain growth factors. He became interested in cancer cell biology with a focus on paediatric cancer of the nervous system, including neuroblastoma. Dr Russo is an Honorary Fellow of the Department of Paediatrics at the University of Melbourne and has provided academic supervision and laboratory training for 40 students.
He is also a National Health and Medical Research Council assessor and an examiner for Honours, Master and PhD theses. He serves as a member of editorial boards and reviewer of leading journals in his fields of expertise.
Dr Russo holds a Doctor of Biology from the University of Padua (Italy) and a PhD in Medicine from The University of Melbourne.
Dr Vincenzo Russo is a leading international researcher in the field of insulin-like growth factors (IGF) and IGF binding proteins (IGFBP). His work and discoveries have greatly contributed to the understanding of the role the IGFBP-2 gene plays in health and disease, particularly its activities in metabolism and cancer.
Dr Russo's research interests also include studies of major brain growth factor systems relevant to brain development, brain injury and nervous system malignancies. The latter focuses on understanding the biology of neuroblastoma (NB) cells, NB cancer stem cells and the development of new anticancer therapeutics to reverse the malignant behaviour of NB cells.
Dr Russo also collaborates with Royal Children's Hospital clinicians and has directed a number of in vitro and in vivo studies related to growth and diabetes complications.
- Dissecting IGFBP-2 nucleo-cytoplasmic shuttling mechanisms in cancer cells.
- Identification of IGFBP-2 genomic binding sites and DNA binding partners in cancer cells.
- Obesity, Diabetes and Cancer Link – A Role For IGFBP-2
- Targeting IGFBP-2 in cancer - Development of novel anti-cancer therapeutics
Yau SW, Henry BA, Russo VC, McConell GK, Clarke IJ, Werther GA, Sabin MA. Leptin Enhances Insulin Sensitivity by Direct and Sympathetic Nervous System Regulation of Muscle IGFBP-2 Expression – Evidence from a non Rodent Models. Endocrinology In Press 2014
Azar WJ, Zivkovic S, Werther GA, Russo VC. IGFBP-2 nuclear translocation is mediated by a functional NLS sequence and is essential for its pro-tumorigenic actions in cancer cells. Oncogene 2014.
Russo VC, Higgins S, Werther GA, Cameron FJ. Effects of Fluctuating Glucose Levels on NeuronalCells In Vitro. Neurochemical Reserach 2012 May 8.
Sabin MA, Russo VC, Azar WJ, Yau SW, Kiess W, Werther GA. IGFBP-2 at the interface of growth andmetabolism-implications for childhood obesity. Pediatr Endocrinol Rev . 2011 Jun;8(4):382-93. Review.
Koves IH, Russo VC, Higgins S, Mishra A, Pitt J, Cameron FJ, Werther GA An In Vitro Paradigm for Diabetic Cerebral Oedema and its Therapy: A Critical Role for Taurine and Water Channels. Neurochemical Reserach 2011.
Azar WJ, Azar SH, Higgins S, Hu JF, Hoffman AR, Newgreen DF, Werther GA, Russo VC. IGFBP-2 Enhances VEGF Gene Promoter Activity andConsequent Promotion of Angiogenesis by Neuroblastoma Cells. Endocrinology. 2011 Sep; 152(9):3332-42.
Sabin MA, Yau SW, Russo VC, Clarke IJ, Dunshea FR, Chau J, Cox M, Werther GA. Dietary Monounsaturated Fat in Early LifeRegulates IGFBP2: Implications for Fat Mass Accretion and Insulin Sensitivity. Obesity (Silver Spring) . 2011 Mar 24.
Christophidis LJ, Gorba T, Gustavsson M, Williams CE, Werther GA, Russo VC, Scheepens A. Growthhormone receptor immunoreactivity is increased in the subventricular zone ofjuvenile rat brain after focal ischemia: a potential role for growth hormone ininjury-induced neurogenesis. Growth Horm IGF Res. 2009 Dec;19(6):497-506.
Higgins S, Wong SHX , Richner M, Rowe CL, Newgreen DF, Werther GA and Russo VC FGF-2 Induced Differentiation Of Neuroblastoma Cells Involves Re-Activation Of G1-Checkpoint Via Regulation Of p21 And Inhibitor Of Differentiation Genes (Id1-3), And Execution Of EMT-Like Events . Endocrinology, 2009 Sep;150(9):4044-55
Poomthavorn P, Wong SHX, Higgins S, Werther GA and Russo VC Activation Of A Prometastatic Gene Expression Program In Hypoxic Neuroblastoma Cells. Endocrine Related Cancer, 2009 Sep;16(3):991-1004.