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Fleur is currently a Post-Doctoral Researcher at the Murdoch Childrens Research Institute. She completed a Bachelor of Applied Science (Hons) in 2008 at the University of Sydney. Fleur was awarded her PhD in 2013 for investigating the molecular mechanisms and effects of a-actinin-3 deficiency in muscle at the Institute of Neuroscience and muscle research, at Westmead Children's Hospital in Sydney.
Fleur has been involved with researching the molecular mechanisms of a-actinin-3 deficiency and muscle adaptation. She is interested in the biological function of muscle and the genes regulating its response to both in performance and disease.
- The use of recombinant adeno associated viral (rAAV) vectors to assess mechanisms of muscle mass and function in wild-type and Actn3 KO mice
- The effect of alpha-actinin-3 in muscle damage and regeneration
- The effect of alpha-actinin-3 on muscle metabolism in response to altered environment (cold and diet)
- Investigating the genetic influences in athletic performance and disease
Garton, F., Seto, J.T., Quinlan, K.G., Yang, N., Houweling, P.J., North, K.N. 2014. a-actinin-3 deficiency and the response to immobilisation and denervation - Human Molecular Genetics, Apr 1;23(7):1879-93. DOI: 10.1093/hmg/ddt580
Sullivan K, El-Hoss J, Quinlan KG, Deo N, Garton F, Seto JT, Gdalevitch M, Turner N, Cooney GJ, Kolanczyk M, North KN, Little DG, Schindeler A. 2014
NF1 is a critical regulator of muscle development and metabolism. Human Molecular Genetics. Mar 1;23(5):1250-9. doi: 10.1093/hmg/ddt515.
Seto, J. T., Quinlan, K. G. R., Lek, M., Zheng, X. F., Garton, F., MacArthur, D. G., Hogarth, M. W., Houweling, P. J., Gregorevic, P., Turner, N., Cooney, G. J., Yang, N. & North, K. N. 2013. ACTN3 genotype influences muscle performance through regulation of calcineurin signalling. Journal of Clinical Investigation. Oct 1;123(10):4255-63. DOI: 10.1172/JCI67691
Eynon, N., Hanson, E. D., Lucia, A., Houweling, P. J., Garton, F., North, K. N. & Bishop, D. J. 2013. Genes for Elite Power and Sprint Performance: ACTN3 Leads the Way. Sports Medicine, 1-15. DOI: 10.1007/s40279-013-0059-4
Pistilli, E. E., Bogdanovich, S., Garton, F., Yang, N., Gulbin, J. P., Conner, J. D., Anderson, B. G., Quinn, L. S., North, K. & Ahima, R. S. 2011. Loss of IL-15 receptor a alters the endurance, fatigability, and metabolic characteristics of mouse fast skeletal muscle. The Journal of Clinical Investigation, 121, 3120. DOI: 10.1172/JCI44945
Seto, J. T., Lek, M., Quinlan, K. G., Houweling, P. J., Zheng, X. F., Garton, F., MacArthur, D. G., Raftery, J. M., Garvey, S. M. & Hauser, M. A. 2011. Deficiency of a-actinin-3 is associated with increased susceptibility to contraction-induced damage and skeletal muscle remodeling. Human Molecular Genetics, 20, 2914-2927. DOI: 0.1093/hmg/ddr196
Garton, F., Seto, J. T., North, K. N. & Yang, N. 2010. Validation of an automated computational method for skeletal muscle fibre morphometry analysis. Neuromuscular Disorders, 20, 540-547. DOI: 10.1016/j.nmd.2010.06.012 (Top 25 Hottest Articles in Neuromuscular Disorders July to September 2010)
Yang, N., Garton, F. & North, K.N. 2009. a-Actinin-3 and Performance. Medicine and Sport Science.54, 88-101 DOI: 10.1159/000235698
Garton, F.C., Houweling. P.J. & North, K.N. The biology and mechanisms behind the gene for speed: ACTN3, genetic and molecular basis of physical fitness, health and performance. Editora Manole, in Press, January 2014