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Dr Gulcan Sarila
Gulcan Sarila started her PhD research investigating the epigenetic gene regulation changes in the developing heart at Monash University. Following her conferral in 2017, she was awarded a Monash University stipend to continue her PhD research, and contributed to the publication "Sex-based Mhrt methylation chromatinizes MeCP2 in the heart" in ISCIENCE 2019. Given Gulcan's strong interest in paediatric research and her desire to help children, she made a strategic decision to change her research focus to clinical paediatrics and joined the surgical research laboratory at Murdoch Children's Research Institute (MCRI) in 2018.
Despite this change in research direction, she has co-authored in "FGF10 and the Mystery of Duodenal Atresia in Humans." Frontiers in Genetics 9 2018; which investigates the congenital obstruction of the duodenum that affects 1 in 7000 pregnancies known as duodenal atresia (DA) as well as submitting her first author paper titled "Interplay Between Collagenase and Undescended Testes in Adamts16 Knockout Rats" to the Journal of Paediatric Surgery 2019.
By collaborating with surgeons and clinicians from the Royal Children's Hospital (RCH), Gulcan not only has the opportunity to work within the laboratory, but also can partner with patients and families into understanding the underlying genetic and molecular causes of various developmental and congenital abnormalities
2019- Catalyst Travel Grant, Murdoch Children's Research Institute
2019- Shortlisted for prize session as well as invited for publication to the Journal of Paediatric Surgery at Annual Pacific Association of Paediatric Surgeons (PAPS) Conference, Christchurch NZ
2017- Post-thesis Stipend (Monash University) from the Department of Diabetes, Monash Central Clinical School, Monash University
2016- First prize oral presentation titled "The role of Set7 in mitochondrial morphology and function" at Australian Society for Medical Research (ASMR), Walter and Eliza Hall Institute (WEHI) Melbourne
2015- Award for poster presentation 1st place "Role of histone methyltransferase Set7 in cardiac gene regulation and function" at International Epigenetic Conference in Tasmania, Australia
2013- PhD Scholarship from Monash University (3yrs)
2014- Oral presentation 2nd place titled "Characterising the role of Set7 in the heart" at ASMR, Research Symposium in Melbourne
1) The effects of ßeta-Calcitonin Gene Receptor Peptide on gene expression and migration in children with undescended testes (UDT).
2) CGRP from the masculinised genitofemoral nerve (GFN) controls gubernaculum migration to the scrotum in mice.
3) Adamnts16 is required for the breakdown of ECM gubernacular migration within the IFP and examine the effect of Adamts16 on the gubernacular migration in rats.
4) Anatomical and physiological characterisation of the Fgf10-deficient mice during embryonic development
2019 Harikrishnan K.N., Okabe J., Mathiyalagan P., Khan A.W, Jadaan S.A, Sarila G, Ziemann, M., Khurana, I., Maxwell, S.S., Du, X.-J., El-Osta, A., Sex-based Mhrt methylation chromatinizes MeCP2 in the heart, ISCIENCE (2019), doi: https://doi.org/10.1016/j.isci.2019.06.031.
2018 Teague, Warwick Jonathan, Matthew Lachlan Markley Jones, Leanne Hawkey, Ian M. Smyth, Angelique Catubig, Sebastian King, Gulcan Sarila, Ruili Li, and John Medwyn Hutson. "FGF10 and the Mystery of Duodenal Atresia in Humans." Frontiers in Genetics 9 (2018): 530.