Dr. Jay Shukla is a post-doctoral research fellow working with Associate Professor Paul Lockhart in the Neurogenetic Research Group (BLC) at the Murdoch Children's Research Institute. Jay completed his PhD in Neuroscience from the Parkinson’s Disease Laboratory at the Florey Institute of Neuroscience and Mental Health in 2019. His PhD research focused on studying the role of biological trace metals (iron and copper) in the pathogenesis of a rare parkinsonian disorder, Multiple System Atrophy (MSA), using a mouse model and post-mortem human brain tissue. This translational research project has led to identification of a potential drug candidate for this rare disease.
Jay is interested in communicating his research to the members of public and has been actively involved in science outreach activities to high school students in order to encourage them to pursue STEM related careers.
Melbourne International Research Scholarship (PhD Scholarship, 2015-2019)
Young Investigator Travel Award, The Multiple System Atrophy Coalition, USA (2019)
At MCRI, Jay's research is focused on understanding the mechanisms involved in beta-propeller protein-associated neurodegeneration (BPAN), a rare, childhood disorder caused by mutation in the WDR45 gene. The project will involve using patient derived stem-cells (iPSC) to study the effect of mutation in the WDR45 gene on iron metabolism and autophagy in the neuronal and glial cells (support cells in the brain). The overall goal of this research is to better understand the disease pathogenesis and identify potential targets for therapy.
Using patient-derived stem cells to study understand molecular mechanisms of Beta-propeller protein-associated neurodegeneration (BPAN)