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Dr Louise Ludlow
Dr Louise Ludlow established and manages the Children's Cancer Centre Tissue Bank which is an essential research enabling platform.
The CCC Tissue Bank, established in April 2014 with funding and support from the Cancer in Kids Auxiliary (CIKA), is one of only three paediatric tissue banks in Australia and comprises a collection of tissue that has been preserved for future clinical investigation and ethically approved research. The Tissue Bank is integral to our efforts to improve diagnostics and develop better “personalised" treatments for children diagnosed with cancer in the future.
Dr Ludlow has extensive experience in cell and molecular biology completing her PhD in cancer research under the supervision of Prof Ricky Johnstone at the Peter MacCallum Cancer Centre. Louise's first postdoctoral position was undertaken in Prof Curt Horvath's Laboratory at Northwestern University, Evanston IL followed by a four year collaborative Research Officer position at The University of Melbourne and the Burnet Institute.
- Honorary Research Officer, Cancer and Disease Epigenetics Group, Murdoch Childrens Research Institute
Dr Ludlow's role involves building a world class cancer tissue bank which is standardised with similar banks within the world's best paediatric cancer research centers. This resource is managed for the benefit of both clinical and laboratory-based researchers within and outside the Melbourne Children's campus.
The CCC Tissue Bank allows collaboration in adequately powered international studies through sample and knowledge sharing ensuring that we remain at the forefront of cutting edge paediatric cancer research.
- Generation of neurosphere cultures from high grade primary brain tumour samples
- Epigenetics of childhood T-ALL
Ludlow, L.E., Johnstone, R.W. and Clarke, C.J. (2005) The HIN-200 family: more than interferon-inducible genes? Exp Cell Res, 308 (1), 1-17. Citations: 118.
Ludlow, L.E, Hii L,L., Thorpe, J., Newbold A., Tainton, K.M., Trapani, J.A., Clarke C.J. and Johnstone, R.W. (2007) Cloning and Characterisation of Ifi206: A new murine HIN-200 family member. J Cell Biochem,103 (4), 1270-82.
Ludlow, L.E., Purton, L., Klarmann K., Gough, D., Hii, L.L., Trapani, J.A., Keller, J., Clarke, C.J. and Johnstone, RW. (2008) The role of p202 in regulating hematopoietic cell proliferation and differentiation. Journal of Interferon and Cytokine Research, 28 (1), 5-11.
Louise E. Ludlow, Michael K. Lo, Jason J. Rodriguez, Paul A. Rota, and Curt M. Horvath (2008) Henipavirus V protein association with Polo-like Kinase Reveals Functional overlap with STAT1 Binding and Interferon Evasion. J Virol, 82 (13), 6259-71.
This manuscript was chosen in Spotlight: articles of significant interest selected from this issue by the editors (J. Virol. July 1, 2008, 82: 6089; doi:10.1128/JVI.00974-08). Citations: 15.
Massich, M.D., Giljohann, D.A., Seferos, D.S., Ludlow, L.E., Horvath, C.M. and Mirkin, C.A. (2009) Regulating immune response using polyvalent nucleic acid-gold nanoparticle conjugates. Mol Pharm, 6 (6), 1934-40.
Bellamy-McIntyre, A.K., Bär, S., Ludlow, L., Drummer, H.E., and Poumbourios, P. (2010) Role for the disulphide-bonded region of human immunodeficiency virus type 1 gp41 in receptor-triggered activation of membrane fusion function. Biochem Biophys Res Commu, 394 (4), 904-8.
Lay, C.S., Ludlow, L.E., Stapleton, D., Bellamy-McIntyre A.K., Ramsland, P.A., Drummer, H.E. and Poumbourios, P. (2011) Role for the Terminal Clasp of HIV-1 gp41 Glycoprotein in the Initiation of Membrane Fusion. J Biol. Chem, 286 (48), 41331-43.
Ludlow, L.E.,* Zhou, J,* Tippett, E., Cheng, W-J., Hasang, W., Rogerson, S.J. and Jaworowski, A. (2012) HIV-1 Inhibits Phagocytosis and Inflammatory Cytokine Responses of Human Monocyte-Derived Macrophages to P. falciparum Infected Erythrocytes. PLoS ONE, 7(2): e32102.
Zhou, J,* Ludlow, L.E.,* Hasang, W., Rogerson, S.J. and Jaworowski, A. (2012) Opsonization of malaria-infected erythrocytes activates the inflammasome and enhances inflammatory cytokine secretion by human macrophages. Malaria Journal, 11(1): 343.
* Equal Contribution
Ludlow, L.E., Hasang, W., Umbers, A.J., Forbes, E.K., Ome, M., Mueller, I., Siba, P.M., Jaworowski, A. and Rogerson, S.J. (2014) Peripheral blood mononuclear cells derived from grand multigravidae display a distinct cytokine profile in response to P. falciparum infected erythrocytes. PLoS ONE, 9(1): e86160
- Cancer in Kids @ RCH
- Leukaemia Auxiliary at RCH (LARCH)