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Dr Mardee Greenham
Dr Mardee Greenham is a Research Officer in the Brain and Mind group within the Clinical Sciences theme at the Murdoch Children's Research Institute (MCRI). Her research has focused on cognitive, behavioural, social and mental health outcomes after paediatric brain injury and she has published extensively in this field. Dr Greenham is particularly interested in paediatric stroke and leads cognitive and behavioural outcome research in the Child Stroke Program at MCRI. She completed her PhD on psychosocial outcomes after paediatric stroke in 2017 and led the development of Australia's first clinical guideline for The Subacute Rehabilitation of Childhood Stroke in 2019. Dr Greenham is also a psychologist and leads the Psychological Assessment service at MCRI.
2019: Finalist, Premier's Awards for Health and Medical Research (Public Health Researcher category)
Dr Greenham's research interests are in childhood acquired brain injury (e.g., stroke, traumatic brain injury, demyelinating conditions). Her research aims to improve our understanding of cognitive and behavioural outcomes following brain injury in children, and identifying ways of treating impairments.
Health and development following paediatric arterial ischaemic stroke
The key difference between children and adults is that paediatric stroke results in changed ability to achieve, rather than the loss of, functional independence. We recruited a group of children when they were dragonised with a stroke and followed them for 5 years. This is the first prospective, longitudinal study to examine the trajectory of recovery following paediatric stroke across multiple domains including cognition, language, motor ability, social skills, mental health and quality of life. Improved understanding of the consequences of paediatric stroke will result in better-informed parents and health professionals, more targeted interventions, and better outcomes for children.
Biomarkers in traumatic brain injury
It is often difficult for doctors to predict how a child will recover after a head injury and which child and family will require more assistance during recovery. This is important since traumatic brain injury may have a negative impact on the quality of life of some children and their families. It has recently been discovered that specific proteins (biomarkers) are released from the brain into the bloodstream following injury. The goal of this study is to find out if by measuring these biomarkers we can more accurately predict recovery in children after a traumatic brain injury. The results of this study may help predict children's recovery needs and may help tailor longer term care.
Stukas S, Higgins V, Frndova H, Gill J, Hubara E, Guerguerian AM, Boutis K, Beauchamp M, Farrell C, Babl FE, Delzoppo C, Greenham M, Wilkinson AA, Crichton A, Anderson V, Adeli K, Hutchison J, Wellington C (2019). Characterisation of serum total tau following paediatric traumatic brain injury: a case-control study. The Lancet Child & Adolescent Health, 3(8), 558-567.
Cooper AN, Anderson V, Greenham M, Hearps S, Hunt RW, Mackay MT, Monagle P, Gordon, AL (2018). Motor function daily living skills 5 years after paediatric arterial ischaemic stroke: a prospective longitudinal study. Developmental Medicine & Child Neurology, 61(2), 161-167.
Greenham M, Gordon A, Cooper A, Ditchfield M, Coleman L, Hunt R, Mackay M, Monagle P, Anderson V (2018). Social functioning following pediatric stroke: contribution of neurobehavioral impairment. Developmental Neuropsychology, 43(3), 1-17.
Crichton A, Anderson V, Oakley E, Greenham M, Hearps S, Delzoppo C, Beauchamp MH, Hutchison J, Gueguerian AM, Boutis K, Babl FE (2018). Fatigue following traumatic brain injury in children and adolescents: a longitudinal follow-up 6 to 12 months after injury. The Journal of head trauma rehabilitation, 33(3), 200-209.
Cooper AN, Anderson V, Hearps S, Greenham M, Hunt RW, Mackay MT, Monagle P, Gordon AL (2018). The Pediatric Stroke Outcome Measure: A predictor of outcome following arterial ischemic stroke. Neurology, 90(5), e365-e372.
Greenham M, Anderson V, Mackay M. (2017). Improving cognitive outcome for childhood stroke. Current Opinion in Neurology, 30, 127-132.
Greenham, M (2017). Cognitive functioning in children after haemorrhagic stroke. Developmental Medicine and Child Neurology, 59(11), 1104.
Greenham M, Anderson V, Cooper A, Ditchfield M, Coleman L, Hunt R, Mackay M, Monagle P, Gordon A. (2017). Early predictors of psychosocial function five years following pediatric stroke. Developmental Medicine & Child Neurology, 59, 1034-1041.
Greenham M, Anderson V, Ditchfield M, Coleman L, Mackay M, Monagle P, Gordon A (2017). Psychosocial function in the first year following childhood stroke. Developmental Medicine and Child Neurology, 59(10), 1027-1033.
Crichton AJ, Babl F, Oakley E, Greenham M, Hearps S, Delzoppo C, Hutchinson J, Beauchamp M, Anderson V (2017). Prediction of multidimensional fatigue after childhood brain injury. Journal of Head Trauma Rehabilitation, 32(2), 107-116.
Crichton A, Babl F, Oakley E, Greenham M, Hearps S, Delzoppo C, Beauchamp M, Hutchison J, Gueguerian AM, Boutis K, Anderson V (2017). Predicting fatigue 12 months after child traumatic brain injury: Child factors and postinjury symptoms. Journal of the International Neuropsychological Society. 24(3), 224-236.
Cooper A, Anderson V, Hearps S, Greenham M, Ditchfield M, Coleman L, Hunt R, Mackay M, Monagle P, Gordon A (2017). Trajectories of motor recovery in the first year following pediatric arterial ischaemic stroke. Pediatrics, 140(2), p.e20163870.
Greenham M, Anderson V, Campbell J, Monagle P, Beauchamp MH (2016). Neuropsychological profiles of children following Vitamin B12 deficiency during infancy: A case series. Brain Impairment, 17(3), 242-253.
Greenham M, Gordon, A, Anderson, V, Mackay M. (2016). Outcome in childhood stroke. Stroke, 47, 1159-1164.
Greenham M, Hearps S, Gomes A, Rinehart N, Gonzlez L, Gordon A, Mackay M, Lo W, Yeates K, Anderson V (2015). Environmental contributions to social and mental health outcomes following pediatric stroke. Developmental Neuropsychology, 40(6), 348-62.
Gordon AL, Anderson V, Ditchfield M, Coleman L, Mackay MT, Greenham M, Hunt RW, Monagle P (2015). Factors associated with six-month outcome of pediatric stroke. International Journal of Stroke, 10(7), 1068-73.
Anderson VA, Spencer-Smith MM, Coleman L, Anderson PJ, Greenham M, Jacobs R, Lee KJ, Leventer RJ (2014). Predicting neurocognitive and behavioural outcome after early brain insult. Developmental Medicine and Child Neurology, 56(4), 329-36.
Gomes A, Rinehart N, Greenham M, Anderson V (2014). A Critical Review of Psychosocial Outcomes Following Childhood Stroke (1995-2012). Developmental Neuropsychology, 39(1), 9-24.
Lo W, Gordon A, Hajek C, Gomes A, Greenham M, Perkins E, Zumberg N, Anderson V, Yeates K, Mackay M (2014). Social competence following neonatal and childhood stroke. International Journal of Stroke, 9(8), 1037–1044.
Hajek CA, Yeates KO, Anderson V, Mackay M, Greenham M, Gomes A, Lo W (2014) Cognitive Outcomes Following Arterial Ischemic Stroke in Infants and Children. Journal of Child Neurology, 29(7), 887-94.
Lo W, Gordon AL, Hajek C, Gomes A, Greenham M, Anderson V, Yeates KO, Mackay MT (2014). Pediatric Stroke Outcome Measure: Predictor of Multiple Impairments in Childhood Stroke. Journal of Child Neurology, 29(11), 1524-30.
Anderson V, Gomes A, Greenham M, Hearps S, Gordon A, Rinehart N, Gonzalez L, Yeates KO, Hajek CA, Lo W, Mackay M (2014). Social competence following pediatric stroke: contributions of brain insult and family environment. Social Neuroscience, 9(5), 471-83.
Greenham M, Spencer-Smith MM, Anderson PJ, Coleman L, Anderson VA (Epub, 2010). Social functioning in children with brain insult. Frontiers in Human Neuroscience, 4(22)
Anderson V, Jacobs R, Spencer-Smith M, Coleman L, Anderson P, Williams J, Greenham M, Leventer R (2010). Does Early Age at Brain Insult Predict Worse Outcome? Neuropsychological Implications. Journal of Pediatric Psychology, 35(7), 716-727.
Anderson V, Spencer-Smith M, Coleman L, Anderson P, Williams J, Greenham M, Leventer RJ, Jacobs R (2010). Children's executive functions: Are they poorer after very early brain insult. Neuropsychologia, 48(7), 2041-2050.
Anderson V, Spencer-Smith M, Leventer R, Coleman L, Anderson P, Williams J, Greenham M, Jacobs R (2009). Childhood brain insult: Can age at insult help us predict outcome? Brain, 132(1), 45-56.
National Stroke Foundation
Victorian Stroke Clinical Network