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Dr Santhosh Kumar Vankayala Ramaiah
Dr Kumar moved to MCRI in 2016 to join Prof. Melissa Little's laboratory as a research officer. He is involved in differentiating human pluripotent stem cells to kidney organoids and optimizing the conditions for scaling up iPSC derived kidney cells.
Honorary Appointment, Department of Paediatrics, University of Melbourne
- ASSCR/NSCFA-Travel award 2017, ISSCR, Melbourne
- Rainer-Greger Promotion Award 2016, DGfN, Berlin
- Best abstract award and travel grant ERA-EDTA-2015, London
- ImmunoTools award 2013
- "SS AWARD-2005", Best Outgoing B. Pharm student for the Year 2005
Kumar SV, Kulkarni OP, Mulay SR, Darisipudi MN, Romoli S, Thomasova D, et al. Neutrophil Extracellular Trap-Related Extracellular Histones Cause Vascular Necrosis in Severe GN. J Am Soc Nephrol. 2015;26(10):2399-413.
Desai J*, Kumar SV*, Mulay SR, Konrad L, Romoli S, Schauer C, et al. PMA and crystal-induced neutrophil extracellular trap formation involves RIPK1-RIPK3-MLKL signaling. Eur J Immunol. 2016;46(1):223-9.
Kumar Vr S, Darisipudi MN, Steiger S, Devarapu SK, Tato M, Kukarni OP, et al. Cathepsin S Cleavage of Protease-Activated Receptor-2 on Endothelial Cells Promotes Microvascular Diabetes Complications. J Am Soc Nephrol. 2016;27(6):1635-49.
Steubl D*, Kumar SV*, Tato M, Mulay SR, Larsson A, Lind L, et al. Circulating cathepsin-S levels correlate with GFR decline and sTNFR1 and sTNFR2 levels in mice and humans. Sci Rep. 2017;7:43538.
Steiger S*, Kumar SV*, Honarpisheh M, Lorenz G, Gunthner R, Romoli S, et al. Immunomodulatory Molecule IRAK-M Balances Macrophage Polarization and Determines Macrophage Responses during Renal Fibrosis. J Immunol. 2017.
Ramaiah SK, Gunthner R, Lech M, Anders HJ. Toll-like receptor and accessory molecule mRNA expression in humans and mice as well as in murine autoimmunity, transient inflammation, and progressive fibrosis. Int J Mol Sci. 2013;14(7):13213-30.
Kumar VR, Inamdar MN, Nayeemunnisa, Viswanatha GL. Protective effect of lemongrass oil against dexamethasone induced hyperlipidemia in rats: possible role of decreased lecithin cholesterol acetyl transferase activity. Asian Pac J Trop Med. 2011;4(8):658-60.
Tato M, Kumar SV, Liu Y, Mulay SR, Moll S, Popper B, et al. Cathepsin S inhibition combines control of systemic and peripheral pathomechanisms of autoimmune tissue injury. Sci Rep. 2017;7(1):2775.
Mulay SR, Desai J, Kumar SV, Eberhard JN, Thomasova D, Romoli S, et al. Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis. Nat Commun. 2016;7:10274.
Nakazawa D, Kumar SV, Marschner J, Desai J, Holderied A, Rath L, et al. Histones and Neutrophil Extracellular Traps Enhance Tubular Necrosis and Remote Organ Injury in Ischemic AKI. J Am Soc Nephrol. 2017.
Andersen K, Kesper MS, Marschner JA, Konrad L, Ryu M, Kumar Vr S, et al. Intestinal Dysbiosis, Barrier Dysfunction, and Bacterial Translocation Account for CKD-Related Systemic Inflammation. J Am Soc Nephrol. 2017;28(1):76-83.
Romoli S, Angelotti ML, Antonelli G, Kumar Vr S, Mulay SR, Desai J, et al. CXCL12 blockade preferentially regenerates lost podocytes in cortical nephrons by targeting an intrinsic podocyte-progenitor feedback mechanism. Kidney Int. 2018.
Kulkarni OP, Hartter I, Mulay SR, Hagemann J, Darisipudi MN, Kumar Vr S, et al. Toll-like receptor 4-induced IL-22 accelerates kidney regeneration. J Am Soc Nephrol. 2014;25(5):978-89.
Devarapu SK, Kumar Vr S, Rupanagudi KV, Kulkarni OP, Eulberg D, Klussmann S, et al. Dual blockade of the pro-inflammatory chemokine CCL2 and the homeostatic chemokine CXCL12 is as effective as high dose cyclophosphamide in murine proliferative lupus nephritis. Clin Immunol. 2016;169:139-47.
Kumar SV, Anders HJ. Glomerular disease: limiting autoimmune tissue injury: ROS and the inflammasome. Nat Rev Nephrol. 2014;10(10):545-6.
Kumar Vr S, Anders HJ. Cathepsins are potential therapeutic targets in kidney disease. Kidney Int. 2016;90(5):933-5.
Allam R, Kumar SV, Darisipudi MN, Anders HJ. Extracellular histones in tissue injury and inflammation. J Mol Med (Berl). 2014;92(5):465-72.
Little MH, Kumar SV, Forbes T. Recapitulating kidney development: Progress and challenges. Semin Cell Dev Biol. 2018.
Mulay SR, Holderied A, Kumar SV, Anders HJ. Targeting Inflammation in So-Called Acute Kidney Injury. Semin Nephrol. 2016;36(1):17-30.
Mulay SR, Kumar SV, Lech M, Desai J, Anders HJ. How Kidney Cell Death Induces Renal Necroinflammation. Semin Nephrol. 2016;36(3):162-73.
Nakazawa D, Kumar S, Desai J, Anders HJ. Neutrophil extracellular traps in tissue pathology. Histol Histopathol. 2017;32(3):203-13.