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Sue Golub is a Senior Research Assistant in the Arthritis Research Group led by Amanda Fosang. She completed her Bachelor of Science (Hons) Degree at LaTrobe University Melbourne and came to work at Murdoch Childrens and The Royal Children's Hospital in John Bateman's group looking at collagen mutations and their role in brittle bone disease. She then joined Amanda's group and has worked on aggrecan, aggrecanases and collagen and their role in cartilage and Arthritis.
She has over 25 years experience in research and the highlight of her career was a Nature publication in 2005 which identified ADAMTS 5 as the major Aggrecanase in mouse cartilage.
Sue has worked on many projects looking at aggrecan degradation in cartilage in knockout mice. She is interested in the biology of cartilage, a complex tissue which is very challenging but interesting to work on. The identification of a bioactive fragment and its role in cartilage and disease is the current focus of her work.
- How aggrecanases contribute to cartilage destruction
- Mice resistant to collagen destruction teach us about skeletal development
- Signalling through a bioactive fragment of aggrecan
- An ultrasensitive assay to detect aggrecan degradation products in patient fluids
Stanton, H., Rogerson, FM., East, CJ., Golub, SB., Lawlor, KE., Meeker, CT, Little, CB., Last, K., Farmer, PJ., Campbell, IK., Fourie, AM., & Fosang, AJ. (2005) ADAMTS-5 is the major aggrecanase in mouse cartilage, in vivo and in vitro. Nature 434, 648-652
Fosang AJ., Golub, SB., East CJ., Rogerson, FM. (2013) Abundant LacZ activity in the absence of Cre expression in the normal and inflamed synovium of adult Col2a1-Cre; ROSA26R(LacZ) reporter mice. Osteoarthritis Cart 21, 401-404
Bastow ER., Last K., Golub, S., Stow J., Stanley A. & Fosang AJ. (2012) Evidence for lysosomal exocytosis and release of aggrecan-degrading hydrolases from hypertrophic chondrocytes, in vitro and in vivo. Biology Open 1, 318-328
Stanton, H., Golub, SB., Rogerson, FM., Last, K., Little, CB., Fosang, AJ. (2011) Investigating ADAMTS-mediated aggrecanolysis in mouse cartilage. Nature Protocols 6, 388-404