Dr Thanh Dang
Thanh completed his Bachelor of Biomedical Science with First Class Honours at Monash University in 2006 before working continuing his research in evaluating the cross reactivity of grass pollen allergies and purifying their major allergens. He has since completed his PhD through the University of Melbourne at the Murdoch Childrens Research Institute, characterising the immunological differences of food allergic individuals in HealthNuts cohort, one of the largest population based cohorts of food allergy in the world.
- NHMRC Early Career Fellowship, 2017-2020
- CFAR Postdoctoral Fellowship, 2014-2016
- CFAR EMCR Researcher Development Award, 2014
- Australian Postgraduate Award (APA), 2009-2012
- Murdoch Childrens Travel Scholarship, 2011
- Melbourne Abroad Travelling Scholarship, 2011
Sensitisation to food allergens indicates the production of food specific IgE, however sensitisation is not a definite indicator of allergic reaction upon ingestion. Currently, food challenge is the best approach to identify presence or absence of allergy. His work looks into elucidating immunological biomarkers to improve the diagnosis of food allergy and reduce the need for oral food challenges.
His other work focuses on understanding the mechanisms behind the development of the food allergy response, in particular, the role of regulatory T cells on the development of the tolerance following allergen exposure. The acquisition of tolerance to food allergens, whereby the immune system is rendered hyporesponsive to antigen after oral feeding, has been extensively characterised in animal models but not in humans.
Dang TD, Peters RL, Allen, KJ. Debates in allergy medicine: baked egg and milk do not accelerate tolerance to egg and milk. World Allergy Organization Journal. 2016 Feb. doi 10.1186/s40413-015-0090-z
Dang TD, Allen KJ, Martino D, Koplin JJ, Licciardi PV, Tang ML. Food allergic infants have impaired regulatory T cell responses following in vivo allergen exposure. Pediatr Allergy Immunol. 2015 Oct 12. doi: 10.1111/pai.12498.
Dang TD, Mills CE, Allen KJ. Determination of the clinical egg allergy phenotypes using component-resolved diagnostics Pediatr Allergy Immunol. 2014 Nov 7. doi: 10.1111/pai.12301.
Dang T, Tang ML, Koplin JJ, et al. Characterization of plasma cytokines in an infant population cohort of challenge-proven food allergy. Allergy. 2013 Oct;68(10):1233-40. doi: 10.1111/all.12215. Epub 2013 Sep 4
Dang T, Tang M, Choo S, et al. Increasing the accuracy of peanut allergy diagnosis using Ara h2. J Allergy Clin Immunol, 2012 Apr;129(4):1056-63
Allen KJ, Koplin JJ, ... Dang T, et al. Vitamin D insufficiency is associated with challenge-proven food allergy in infants. J Allergy Clin Immunol. 2013 Apr;131(4):1109-16, 1116.e1-6. doi: 10.1016/j.jaci.2013.01.017
Tan T, Dang T, Allen K, et al. Filaggrin loss-of-function mutations do not predict food allergy over and above the risk of food sensitization among infants. J Allergy Clin Immunol. 2012 Nov;130(5):1211-1213
Koplin J, Osborne N, Dang T, et al. Can early introduction of egg prevent egg allergy in infants? – a population-based study. J Allergy Clin Immunol 2010 Oct;126(4):807-13.
Koplin JJ, Suaini NH, Vuillermin P, … Dang T, et al. Polymorphisms affecting vitamin D-binding protein modify the relationship between serum vitamin D (25[OH]D3) and food allergy. J Allergy Clin Immunol. 2015 Aug 7. pii: S0091-6749(15)00911-2. doi: 10.1016
Ashley S, Dang T, Koplin J, Martino D, Prescott S. Food for thought: progress in understanding the causes and mechanisms of food allergy. Curr Opin Allergy Clin Immunol. 2015 Jun;15(3):237-42. doi: 10.1097
Martino D, Dang T, Sexton-Oates A, Prescott S, Tang ML, et al. Blood DNA methylation biomarkers predict clinical reactivity in food-sensitized infants. J Allergy Clin Immunol. 2015 Feb 10. doi: 10.1016/j.jaci.2014.12.1933.
Peters RL, Allen KJ, Dharmage SC, Koplin JJ, Dang T, et al. Natural history of peanut allergy and predictors of resolution in the first 4 years of life: A population-based assessment. J Allergy Clin Immunol. 2015 Feb 25. doi: 10.1016/j.jaci.2015.01.002.
Tan HT, Ellis JA, Koplin JJ, Martino D, Dang TD, et al. Methylation of the filaggrin gene promoter does not affect gene expression and allergy. Pediatr Allergy Immunol. 2014 Oct;25(6):608-10. doi: 10.1111/pai.12245.
Martino D, Joo JE, Sexton-Oates A, Dang T, et al. Epigenome-wide association study reveals longitudinally stable DNA methylation differences in CD4+ T cells from children with IgE-mediated food allergy. Epigenetics. 2014 Apr 24;9(7).