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Details

Role Theme Director - Stem Cell Biology
Research area Stem cell biology

Contact

Available for student supervision
Professor Porrello is the Theme Director of Stem Cell Biology and Head of the Heart Regeneration Group at the Murdoch Children’s Research Institute. He also directs the Melbourne Node of the recently established Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW) and he is the founding Co-Director of the Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine (CardioRegen). Prof Porrello’s research focuses on the development of regenerative therapies for children and adults with heart failure. Over the course of his career, he has made important contributions to our understanding of mammalian heart regeneration and has pioneered the development of human organoids for drug discovery. Prof Porrello is a co-founder of Dynomics, a biotechnology company focused on the development of new heart failure treatments using organoid technologies.

After completing his PhD in Physiology at The University of Melbourne, Prof Porrello was awarded an NHMRC/NHF C.J. Martin Fellowship to undertake postdoctoral training in Prof Eric Olson's laboratory at UT Southwestern Medical Center in Dallas, USA. Upon returning to Australia in 2012, Prof Porrello established the Cardiac Regeneration Laboratory at The University of Queensland, which he co-headed together with Dr James Hudson from 2013-2017.
Professor Porrello is the Theme Director of Stem Cell Biology and Head of the Heart Regeneration Group at the Murdoch Children’s Research Institute. He also directs the Melbourne Node of the recently established Novo Nordisk Foundation Centre for...
Professor Porrello is the Theme Director of Stem Cell Biology and Head of the Heart Regeneration Group at the Murdoch Children’s Research Institute. He also directs the Melbourne Node of the recently established Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW) and he is the founding Co-Director of the Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine (CardioRegen). Prof Porrello’s research focuses on the development of regenerative therapies for children and adults with heart failure. Over the course of his career, he has made important contributions to our understanding of mammalian heart regeneration and has pioneered the development of human organoids for drug discovery. Prof Porrello is a co-founder of Dynomics, a biotechnology company focused on the development of new heart failure treatments using organoid technologies.

After completing his PhD in Physiology at The University of Melbourne, Prof Porrello was awarded an NHMRC/NHF C.J. Martin Fellowship to undertake postdoctoral training in Prof Eric Olson's laboratory at UT Southwestern Medical Center in Dallas, USA. Upon returning to Australia in 2012, Prof Porrello established the Cardiac Regeneration Laboratory at The University of Queensland, which he co-headed together with Dr James Hudson from 2013-2017.

Top Publications

  • Arasaratnam, D, Bell, KM, Sim, CB, Koutsis, K, Anderson, DJ, Qian, EL, Stanley, EG, Elefanty, AG, Cheung, MM, Oshlack, A, et al. The role of cardiac transcription factor NKX2-5 in regulating the human cardiac miRNAome. Scientific Reports 9(1) : 15928 2023
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  • Anderson, DJ, Kaplan, DI, Bell, KM, Koutsis, K, Haynes, JM, Mills, RJ, Phelan, DG, Qian, EL, Leitoguinho, AR, Arasaratnam, D, et al. NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network. Nature Communications 9(1) : 1373 2023
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  • Arasaratnam, D, Bell, KM, Sim, CB, Koutsis, K, Anderson, DJ, Qian, EL, Stanley, EG, Elefanty, AG, Cheung, MM, Oshlack, A, et al. Publisher Correction: The role of cardiac transcription factor NKX2-5 in regulating the human cardiac miRNAome. Scientific Reports 9(1) : 20269 2023
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  • Titmarsh, DM, Glass, NR, Mills, RJ, Hidalgo, A, Wolvetang, EJ, Porrello, ER, Hudson, JE, Cooper-White, JJ. Induction of Human iPSC-Derived Cardiomyocyte Proliferation Revealed by Combinatorial Screening in High Density Microbioreactor Arrays. Scientific Reports 6(1) : 24637 2023
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  • Loh, Z, Simpson, J, Ullah, A, Zhang, V, Gan, WJ, Lynch, JP, Werder, RB, Sikder, AA, Lane, K, Sim, CB, et al. HMGB1 amplifies ILC2-induced type-2 inflammation and airway smooth muscle remodelling. PLOS Pathogens 16(7) : e1008651 2023
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