Professor Porrello is the Theme Director of Stem Cell Biology and Head of the Heart Regeneration Group at the Murdoch Children’s Research Institute. He also directs the Melbourne Node of the recently established Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW) and he is the founding Co-Director of the Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine (CardioRegen). Prof Porrello’s research focuses on the development of regenerative therapies for children and adults with heart failure. Over the course of his career, he has made important contributions to our understanding of mammalian heart regeneration and has pioneered the development of human organoids for drug discovery. Prof Porrello is a co-founder of Dynomics, a biotechnology company focused on the development of new heart failure treatments using organoid technologies.
After completing his PhD in Physiology at The University of Melbourne, Prof Porrello was awarded an NHMRC/NHF C.J. Martin Fellowship to undertake postdoctoral training in Prof Eric Olson's laboratory at UT Southwestern Medical Center in Dallas, USA. Upon returning to Australia in 2012, Prof Porrello established the Cardiac Regeneration Laboratory at The University of Queensland, which he co-headed together with Dr James Hudson from 2013-2017.
Professor Porrello is the Theme Director of Stem Cell Biology and Head of the Heart Regeneration Group at the Murdoch Children’s Research Institute. He also directs the Melbourne Node of the recently established Novo Nordisk Foundation Centre for...
Professor Porrello is the Theme Director of Stem Cell Biology and Head of the Heart Regeneration Group at the Murdoch Children’s Research Institute. He also directs the Melbourne Node of the recently established Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW) and he is the founding Co-Director of the Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine (CardioRegen). Prof Porrello’s research focuses on the development of regenerative therapies for children and adults with heart failure. Over the course of his career, he has made important contributions to our understanding of mammalian heart regeneration and has pioneered the development of human organoids for drug discovery. Prof Porrello is a co-founder of Dynomics, a biotechnology company focused on the development of new heart failure treatments using organoid technologies.
After completing his PhD in Physiology at The University of Melbourne, Prof Porrello was awarded an NHMRC/NHF C.J. Martin Fellowship to undertake postdoctoral training in Prof Eric Olson's laboratory at UT Southwestern Medical Center in Dallas, USA. Upon returning to Australia in 2012, Prof Porrello established the Cardiac Regeneration Laboratory at The University of Queensland, which he co-headed together with Dr James Hudson from 2013-2017.
Top Publications
Porrello, ER, Widdop, RE, Delbridge, LM.
EARLY ORIGINS OF CARDIAC HYPERTROPHY: DOES CARDIOMYOCYTE ATTRITION PROGRAMME FOR PATHOLOGICAL ‘CATCH‐UP’ GROWTH OF THE HEART?.
Clinical and Experimental Pharmacology and Physiology
35(11)
:
1358 -1364
2008
view publication
Bell, JR, Porrello, ER, Huggins, CE, Harrap, SB, Delbridge, LMD.
The intrinsic resistance of female hearts to an ischemic insult is abrogated in primary cardiac hypertrophy.
AJP Heart and Circulatory Physiology
294(4)
:
h1514 -h1522
2008
view publication
Porrello, E, Bell, J, Harrap, S, Thomas, W, Delbridge, L.
Reduced Levels of Activated ERK1/2 and p38 MAPK are Associated with Neonatal Cardiac and Cardiomyocyte Growth Restriction in the Hypertrophic Heart Rat (HHR).
Heart Lung and Circulation
17:
s225
2008
view publication
Bell, J, Porrello, E, Harrap, S, Thomas, W, Delbridge, L.
Differential Activities of Cardiac Hypertrophic Signalling Pathways in Neonatal and Adult Hypertrophic Heart Rats (HHR).
Heart Lung and Circulation
17:
s230
2008
view publication
Porrello, ER, Schertzer, JD, Curl, CL, Lynch, GS, Harrap, SB, Thomas, WG, Delbridge, LMD.
Elevated levels of phosphorylated Akt in hypertrophy pre-destined neonatal hearts.
Journal of Molecular and Cellular Cardiology
42(6)
:
s133
2007
view publication