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Details

Role Theme Director - Stem Cell Medicine
Research area Stem Cell Medicine

Contact

Available for student supervision
Professor Porrello is the Theme Director of Stem Cell Medicine and Head of the Heart Regeneration group at the Murdoch Children’s Research Institute. He also directs the Melbourne Node of the recently established Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW) and he is the founding Co-Director of the Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine (CardioRegen). Professor Porrello’s research focuses on the development of regenerative therapies for children and adults with heart failure. Throughout his career, he has made important contributions to our understanding of mammalian heart regeneration and has pioneered the development of human organoids for drug discovery. Professor Porrello is a co-founder of Dynomics, a biotechnology company focused on the development of new heart failure treatments using organoid technologies.

After completing his PhD in Physiology at the University of Melbourne, Professor Porrello was awarded an NHMRC/NHF C.J. Martin Fellowship to undertake postdoctoral training in Prof Eric Olson's laboratory at UT Southwestern Medical Center in Dallas, USA. Upon returning to Australia in 2012, Professor Porrello established the Cardiac Regeneration Laboratory at The University of Queensland, which he co-headed together with Dr James Hudson from 2013-2017.
Professor Porrello is the Theme Director of Stem Cell Medicine and Head of the Heart Regeneration group at the Murdoch Children’s Research Institute. He also directs the Melbourne Node of the recently established Novo Nordisk Foundation Centre for...
Professor Porrello is the Theme Director of Stem Cell Medicine and Head of the Heart Regeneration group at the Murdoch Children’s Research Institute. He also directs the Melbourne Node of the recently established Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW) and he is the founding Co-Director of the Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine (CardioRegen). Professor Porrello’s research focuses on the development of regenerative therapies for children and adults with heart failure. Throughout his career, he has made important contributions to our understanding of mammalian heart regeneration and has pioneered the development of human organoids for drug discovery. Professor Porrello is a co-founder of Dynomics, a biotechnology company focused on the development of new heart failure treatments using organoid technologies.

After completing his PhD in Physiology at the University of Melbourne, Professor Porrello was awarded an NHMRC/NHF C.J. Martin Fellowship to undertake postdoctoral training in Prof Eric Olson's laboratory at UT Southwestern Medical Center in Dallas, USA. Upon returning to Australia in 2012, Professor Porrello established the Cardiac Regeneration Laboratory at The University of Queensland, which he co-headed together with Dr James Hudson from 2013-2017.

Top Publications

  • Nagareddy, PR, Sreejit, G, Lee, MK, Athmanathan, B, Quaife-Ryan, GA, Abdel-Latif, A, Porrello, ER, Murphy, A. Abstract 228: Inflammasome-Primed Neutrophils Return to the Bone Marrow to Stimulate Leukocytosis Following Myocardial Infarction. Circulation Research 127(Suppl_1) : 2020
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  • Loh, Z, Simpson, J, Ullah, A, Zhang, V, Gan, WJ, Lynch, JP, Werder, RB, Sikder, AA, Lane, K, Sim, CB, et al. HMGB1 amplifies ILC2-induced type-2 inflammation and airway smooth muscle remodelling.. PLoS Pathog 16(7) : e1008651 2020
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  • Sadek, HA, Porrello, ER. Neonatal heart regeneration: Moving from phenomenology to regenerative medicine.. J Thorac Cardiovasc Surg 159(6) : 2451 -2455 2020
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  • Bywater, MJ, Burkhart, DL, Straube, J, Sabò, A, Pendino, V, Hudson, JE, Quaife-Ryan, GA, Porrello, ER, Rae, J, Parton, RG, et al. Reactivation of Myc transcription in the mouse heart unlocks its proliferative capacity.. Nat Commun 11(1) : 1827 2020
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  • Sreejit, G, Abdel-Latif, A, Athmanathan, B, Annabathula, R, Dhyani, A, Noothi, SK, Quaife-Ryan, GA, Al-Sharea, A, Pernes, G, Dragoljevic, D, et al. Neutrophil-Derived S100A8/A9 Amplify Granulopoiesis After Myocardial Infarction.. Circulation 141(13) : 1080 -1094 2020
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