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Dr Kevin Watt

Dr Kevin Watt

Details

Role Team Leader, Therapeutic Development
Research area Stem Cell Medicine

Contact

Dr. Kevin Watt is a Team Leader in the Heart Regeneration and Disease Laboratories at Murdoch Children's Research Institute. Our vision is to develop targeted therapies to treat heart failure in children. Our team are internationally recognised for our expertise using pluripotent stem cells and animal models to study the fundamental mechanisms governing muscle development, maturation and regeneration. Building on our broad knowledge base, we seek to translate these fundamental discoveries towards new pharmacological and cell-based therapeutics to treat childhood cardiomyopathy and cardiotoxicity.

Dr. Watt obtained a PhD at the University of Aberdeen, UK (2010) and completed post-doctoral research positions at the Peter MacCallum Cancer Centre (2010), Baker Institute (2011-2018) and Centre of Muscle Research at The University of Melbourne (2018-2022). His work has been published in leading journals in the field including 2 x first author articles in Nature Communications and co-author publications in Nature, Cell Metab, Sci Transl Medicine, Circulation. Since 2021, Dr. Watt has served as a member of the council of the Australian Physiology Society.
Dr. Kevin Watt is a Team Leader in the Heart Regeneration and Disease Laboratories at Murdoch Children's Research Institute. Our vision is to develop targeted therapies to treat heart failure in children. Our team are internationally recognised for...
Dr. Kevin Watt is a Team Leader in the Heart Regeneration and Disease Laboratories at Murdoch Children's Research Institute. Our vision is to develop targeted therapies to treat heart failure in children. Our team are internationally recognised for our expertise using pluripotent stem cells and animal models to study the fundamental mechanisms governing muscle development, maturation and regeneration. Building on our broad knowledge base, we seek to translate these fundamental discoveries towards new pharmacological and cell-based therapeutics to treat childhood cardiomyopathy and cardiotoxicity.

Dr. Watt obtained a PhD at the University of Aberdeen, UK (2010) and completed post-doctoral research positions at the Peter MacCallum Cancer Centre (2010), Baker Institute (2011-2018) and Centre of Muscle Research at The University of Melbourne (2018-2022). His work has been published in leading journals in the field including 2 x first author articles in Nature Communications and co-author publications in Nature, Cell Metab, Sci Transl Medicine, Circulation. Since 2021, Dr. Watt has served as a member of the council of the Australian Physiology Society.

Top Publications

  • Huurne, MT, Parker, BL, Liu, NQ, Qian, EL, Vivien, C, Karavendzas, K, Mills, RJ, Saville, JT, Abu-Bonsrah, D, Wise, AF, et al. GLA-modified RNA treatment lowers GB3 levels in iPSC-derived cardiomyocytes from Fabry-affected individuals. American Journal of Human Genetics 110(9) : 1600 -1605 2023
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  • Montgomery, MK, Bayliss, J, Nie, S, de Nardo, W, Keenan, SN, Anari, M, Taddese, AZ, Williamson, NA, Ooi, GJ, Brown, WA, et al. Liver-Secreted Hexosaminidase A Regulates Insulin-Like Growth Factor Signaling and Glucose Transport in Skeletal Muscle.. Diabetes 72(6) : 715 -727 2023
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  • McNamara, JW, Parker, BL, Voges, HK, Mehdiabadi, NR, Bolk, F, Ahmad, F, Chung, JD, Charitakis, N, Molendijk, J, Zech, ATL, et al. Alpha kinase 3 signaling at the M-band maintains sarcomere integrity and proteostasis in striated muscle. Nature Cardiovascular Research 2(2) : 159 -173 2023
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  • Molendijk, J, Blazev, R, Mills, RJ, Ng, Y-K, Watt, KI, Chau, D, Gregorevic, P, Crouch, PJ, Hilton, JBW, Lisowski, L, et al. Proteome-wide systems genetics identifies UFMylation as a regulator of skeletal muscle function.. Elife 11: 2022
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  • Molendijk, J, Blazev, R, Mills, RJ, Ng, Y-K, Watt, KI, Chau, D, Gregorevic, P, Crouch, PJ, Hilton, JBW, Lisowski, L, et al. Proteome-wide systems genetics identifies UFMylation as a regulator of skeletal muscle function. 2022
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