Facial Sciences Research
Advancing surgical and psychosocial outcomes for children with structural differences
The Facial Sciences research group at MCRi focuses on plastic and maxillofacial surgery which is broadly concerned with reconstruction or restoration of the body’s structure and function.
Structural deficiencies may arise from trauma, tumour removal, or developmental differences present from birth such as:
- hand differences
- cleft lip and palate
- micrognathia
- vascular anomalies
The challenges
Parents often ask their plastic or maxillofacial surgeon ”Will my child be okay?” Offering accurate responses, based on evidence, to this seemingly simple question is in practice extremely difficult. What does okay mean?:
- Physically okay? Psychologically okay? Socially okay?
- All of the above?
- How much “okay” is enough?
- How many operations will it take to be “okay”?
Diverse conditions and lifelong impact
The conditions treated are many and varied, affecting any area of the body and all age groups. Conditions treated in childhood may have consequences throughout growth and development, into adulthood and beyond.
Physical and psychosocial interconnection
Physical and psychosocial function are often intricately entwined. While restoring physical function is frequently the healthcare provider’s primary objective, the psychosocial effects, which are often highly specific to the individual andmore difficult to measure, may dominate for the patient and may indeed change between childhood, adolescence and adulthood.
Challenges in measuring psychosocial outcomes
There is a lack of quantitative data, and adequate measurement tools to evaluate psychosocial outcomes in many of the conditions we treat. Existing studies rarely extend beyond the perioperative phase, making it hard to know whether the interventions we believe are effective actually matter to children.
Our research focus
The focus of our research program is to first define outcomes that matter to the children we care for and collect these data uniformly into adulthood. Such data will allow us to better define the needs and expectations of children and their parents and to clarify how best to achieve this.
An archetype of this approach is the Australian Hand Differences Register which is housed and coordinated by Murdoch Children's Research Institute and collects patient reported outcome data on children born with upper limb differences from 11 sites across Australia from birth to 18 years and beyond.
More information
- Australian Hand Difference Register (AHDR)
- RCH Plastic and Maxillofacial Surgery Department
- Australian Society of Plastic Surgeons
- The Australian Hand Surgery Society
- Pediatric Hand International Society of Surgeons
- Jigsaw Foundation
Contact us
Plastic and Maxillofacial Surgery
Clinical Offices (3 West)
The Royal Children's Hospital
Flemington Rd Parkville
Victoria 3052 Australia
Phone:
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Fax: +61 3 9345 6585
Email: [email protected]
Group Leaders
Group Members
Hand & Microsurgery
Australian Hand Differences Register (AHDR)
The Australian Hand Differences Register (AHDR) is a national, population-based register that systematically records data on children born with hand differences in Australia. This comprehensive register enables large-scale assessment of the implications of upper limb differences, facilitating improved understanding, management, and outcomes.
The AHDR collects both epidemiological and outcome data using the Patient-Reported Outcomes Measurement Information System (PROMIS®) tools to assess physical and psychosocial function in children enrolled in the register.
Current projects using AHDR data:
- Consistency of classification techniques of thumb duplication
- Outcomes of surgery for thumb duplication
- Evaluation of parental and adolescent experience in patients with congenital upper limb differences and their families
- Comparison of appearance outcome measures in patients with congenital upper limb differences
- Analysis of the functional and psychosocial impact of congenital upper limb differences using PROMIS®
Maximising nerve recovery following supracondylar humerus fractures: A randomised control trial
This multicentre, pragmatic trial is an international collaboration between The Royal Children’s Hospital, Boston Children’s Hospital, The Hospital for Sick Children (Toronto), and Leeds Teaching Hospital (UK). The study aims to determine whether early nerve exploration improves or expedites recovery of nerve function. It is planned to run over five years and will be led by The Royal Children’s Hospital.
Nail Bed INJury Analysis – NINJA 2 Trial
This multicentre, randomised controlled trial investigates whether nailbed injuries in children are better managed with suture repair or dressing. It is an international collaboration with the University of Oxford, UK.
Craniofacial & cleft surgery
Use of 3D imaging in analysis of long-term craniofacial outcomes
The Royal Children’s Hospital (RCH) has developed a comprehensive normative craniofacial database, unique internationally. Using this database, researchers have assessed long-term outcomes in patients with metopic synostosis who underwent corrective surgery in infancy.
Advanced warping techniques and mathematical analysis of patient photographs compared with the normative database have provided valuable insights into expected outcomes. This ongoing project will be extended to other forms of synostosis.
Institutional bollaboration: Department of Human Genetics, Leuven, Belgium
In-vitro assessment of the strength of bioresorbable plates in craniofacial surgery
Bioresorbable plates are commonly used in craniofacial surgery to fixate bone. However, there is limited data on their initial strength and degradation rate post-surgery. This project aims to provide surgeons with critical information on the performance of these materials.
Oral & maxillofacial surgery (OMS)
The OMS program conducts ongoing clinical outcome projects focused on:
- Management of upper airway obstruction in children
- Management of skeletal deformities of the face and jaws due to congenital cleft and craniofacial anomalies
These projects involve interdisciplinary collaboration with neonatology, otolaryngology, respiratory medicine, and dentistry.
Upper airway obstruction due to micrognathia
Micrognathia, a common congenital anomaly associated with conditions such as Robin Sequence, craniofacial microsomia, and Treacher Collins syndrome, can cause upper airway obstruction. Our research focuses on outcomes for patients undergoing mandibular distraction to manage this condition.
Dentofacial deformity & TMJ reconstruction
Dentofacial deformities resulting from skeletal growth disturbances due to cleft lip and palate or syndromic conditions can lead to malocclusion and temporomandibular joint (TMJ) dysfunction. Our projects examine:
- Outcomes of maxillary cleft grafting
- Surgical approaches for correcting skeletal deformities
- TMJ reconstruction techniques
Funding
Thank you to our supporters.
- The Jigsaw Foundation
- The Royal Children’s Hospital Foundation
- Medical Research Future Fund (MRFF)
- AHDR - McNally Foundation grant
- Myers family gift
- ASPS Research grant
- Wilson advisory group gift
- Australasian Foundation for Plastic Surgery
Collaborations
We collaborate with leading institutions worldwide, including:
- The Royal Children's Hospital (RCH)
- RCH Department of Orthopaedics and Neurology - Brachial Plexus
- RCH Department of Orthopaedics – Sarcoma
- International Federation of Surgical Societies of the Hand - Congenital Hand Sub-committee
- UK Reconstructive Surgery Trials
- Network Department of Human Genetics, Leuven, Belgium
- University of Oxford UK
Featured publications
Muggli, E., Halliday, J., Hearps, S., Nguyen, T., Penington, A., Thompson, D. K., Spittle, A., Forster, D. A., Lewis, S., Elliott, E. J., Anderson, P. J., et al. (2024). Low to moderate prenatal alcohol exposure and neurodevelopment in a prospective cohort of early school aged children. Scientific Reports, 14(1), 7302.
Green, T. E., Garza, D., Brown, N. J., de Silva, M. G., Bennett, M. F., Tubb, C., Phillips, R. J., MacGregor, D., Robertson, S. J., Bekhor, P., Simpson, J., et al. (2024). Improving genetic diagnostic yield in a large cohort of children with rare vascular anomalies or PIK3CA-related overgrowth spectrum. Genetics in Medicine Open, 2, 100837.
Sandvall, B., Atkins, S., McCombe, D., Bellew, M., Coombs, C. J., & Penington, A. J. (2022). Satisfaction with hand appearance in children with index pollicization for thumb hypoplasia. Journal of Plastic, Reconstructive & Aesthetic Surgery, 75(9), 3234–3241.
Chong, D. K., Somasundaram, M., Ho, E., Dhooghe, N. S., & Fisher, D. M. (2022). Comparison of presurgical anthropometric measures of right and left complete unilateral cleft lip and/or palate. Plastic and Reconstructive Surgery, 149(2), 248e–253e.
Wilks DJ, Ye X, Biggins R, Wang KK, Wade RG, McCombe D. Median Nerve Palsy in Pediatric Supracondylar Humerus Fractures Recovers Faster With Open Than Closed Reduction. J Pediatr Orthop. 2023 Aug 1;43(7):407-413. doi: 10.1097/BPO.0000000000002424. Epub 2023 May 15. PMID: 37193652.
Matthews, H. S., Mahdi, S., Penington, A. J., Marazita, M. L., Shaffer, J. R., Walsh, S., Shriver, M. D., Claes, P., & Weinberg, S. M. (2023). Using data-driven phenotyping to investigate the impact of sex on 3D human facial surface morphology. Journal of Anatomy, 243(2), 274–283.
Van Slyke, A. C., Burge, J., Bos, R., Parker, G., & Chong, D. K. (2022). The Anatomical Subunit Approach to Managing Tessier Numbers 3 and 4 Craniofacial Clefts. Plastic and Reconstructive Surgery Global Open, 10(9), e4553.
Costello, B. J., Rivera, R. D., Shand, J., & Mooney, M. (2012). Growth and development considerations for craniomaxillofacial surgery. Oral and Maxillofacial Surgery Clinics of North America, 24(3), 377–396.
Heggie, A. A., Kumar, R., & Shand, J. M. (2013). The role of distraction osteogenesis in the management of craniofacial syndromes. Annals of Maxillofacial Surgery, 3(1), 4–10.
Levi, E., Alexander, W., & Cooper, M. S. (2024). Management of paediatric sialorrhea. Current Opinion in Otolaryngology & Head and Neck Surgery, 32(6), 444–452.