Our laboratory uses stem cells to generate human bioengineered muscle, both skeletal muscle and heart muscle.

This enables ‘disease in a dish’ studies that allow us to understand how muscle is perturbed due to genetic or environmental disorders. These ‘mini-muscles’ act and function like the muscle in your body, giving us the unique ability to measure important properties like muscle strength.

As we can generate 1000s of mini-muscles, it provides unprecedented access to human tissue for cell biology, and disease modelling studies. Using this approach, we aim to gain insight into childhood myopathies in order to develop new therapies. 

Video: Cardiac organoids (heart muscle) beating in a dish.

Video: Bioengineered skeletal muscle contracting and producing force in a dish.