photo of A/Prof Richard Mills

A/Prof Richard Mills

A/Prof Richard Mills

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Role Group Leader / Principal Research Fellow
Research area Stem Cell Medicine

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A/Prof Richard Mills generates lab-made muscle tissue, which acts and functions like the muscle in your body, to understand disease and find new treatments.

A/Prof Richard Mills’ laboratory uses stem cells to generate human skeletal muscle and heart muscle tissues in the lab. This enables ‘disease in a dish’ studies that allows his lab to understand muscle disease. These ‘mini muscles’ act and function like the muscle in your body, giving Mills and his team the unique ability to measure important properties like muscle strength, kinetics and endurance. Using this approach, they can generate thousands of mini muscles for cell biology, and disease modelling applications; with the aim of finding new therapies for muscle disease.

A/Prof Richard Mills is principal investigator at the reNEW Melbourne node, and the group leader of the Muscle Bioengineering Laboratory at the Murdoch Children’s Research Institute (MCRI). Mills holds a PhD in biomedical engineering from the University of Queensland, Brisbane and completed post-doctoral training at The Karolinska Institute, Stockholm and QIMR Berghofer Medical Research Institute, Brisbane.
A/Prof Richard Mills generates lab-made muscle tissue, which acts and functions like the muscle in your body, to understand disease and find new treatments.

A/Prof Richard Mills’ laboratory uses stem cells to generate human skeletal muscle and...
A/Prof Richard Mills generates lab-made muscle tissue, which acts and functions like the muscle in your body, to understand disease and find new treatments.

A/Prof Richard Mills’ laboratory uses stem cells to generate human skeletal muscle and heart muscle tissues in the lab. This enables ‘disease in a dish’ studies that allows his lab to understand muscle disease. These ‘mini muscles’ act and function like the muscle in your body, giving Mills and his team the unique ability to measure important properties like muscle strength, kinetics and endurance. Using this approach, they can generate thousands of mini muscles for cell biology, and disease modelling applications; with the aim of finding new therapies for muscle disease.

A/Prof Richard Mills is principal investigator at the reNEW Melbourne node, and the group leader of the Muscle Bioengineering Laboratory at the Murdoch Children’s Research Institute (MCRI). Mills holds a PhD in biomedical engineering from the University of Queensland, Brisbane and completed post-doctoral training at The Karolinska Institute, Stockholm and QIMR Berghofer Medical Research Institute, Brisbane.

Top Publications

  • Mills, RJ, Humphrey, SJ, Fortuna, PRJ, Lor, M, Foster, SR, Quaife-Ryan, GA, Johnston, RL, Dumenil, T, Bishop, C, Rudraraju, R, et al. BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection.. Cell 184(8) : 2167 -2182.e22 2021
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  • Mills, RJ, Parker, BL, Quaife-Ryan, GA, Voges, HK, Needham, EJ, Bornot, A, Ding, M, Andersson, H, Polla, M, Elliott, DA, et al. Drug Screening in Human PSC-Cardiac Organoids Identifies Pro-proliferative Compounds Acting via the Mevalonate Pathway.. Cell Stem Cell 24(6) : 895 -907.e6 2019
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  • Mills, RJ, Parker, BL, Monnot, P, Needham, EJ, Vivien, CJ, Ferguson, C, Parton, RG, James, DE, Porrello, ER, Hudson, JE. Development of a human skeletal micro muscle platform with pacing capabilities.. Biomaterials 198: 217 -227 2019
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  • Mills, R, Taylor-Weiner, H, Correia, JC, Agudelo, LZ, Allodi, I, Kolonelou, C, Martinez-Redondo, V, Ferreira, DMS, Nichterwitz, S, Comley, LH, et al. Neurturin is a PGC-1α1-controlled myokine that promotes motor neuron recruitment and neuromuscular junction formation.. Mol Metab 7: 12 -22 2018
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  • Mills, RJ, Titmarsh, DM, Koenig, X, Parker, BL, Ryall, JG, Quaife-Ryan, GA, Voges, HK, Hodson, MP, Ferguson, C, Drowley, L, et al. Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest.. Proc Natl Acad Sci U S A 114(40) : E8372 -E8381 2017
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