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This CRE has been archived.

This CRE was a five-year research program 2021–2025 funded by the National Health and Medical Research Council (NHMRC).

The Centre for Research Excellence for Pneumococcal Disease Control (CRE-PDCin the Asia-Pacific generated new evidence to support decisions regarding the sustainability of national immunisation for pneumococcal conjugate vaccine (PCV) programs.

This CRE was a five-year research program 2021–2025 funded by the National Health and Medical Research Council (NHMRC).

The Centre for Research Excellence for Pneumococcal Disease Control (CRE-PDCin the Asia-Pacific generated new evidence...

This CRE was a five-year research program 2021–2025 funded by the National Health and Medical Research Council (NHMRC).

The Centre for Research Excellence for Pneumococcal Disease Control (CRE-PDCin the Asia-Pacific generated new evidence to support decisions regarding the sustainability of national immunisation for pneumococcal conjugate vaccine (PCV) programs.

About the CRE-PDC

According to the World Health Organization (WHO), pneumonia is the single biggest killer of children globally, accounting for the deaths of approximately 1.4 million children aged under five years each year. Pneumonia is more common in South Asia and sub-Saharan Africa.

Surveillance for pneumococcal disease is important to describe disease trends, monitor changes in the frequency of antimicrobial-resistant strains, describe changes in pneumococcal serotypes (strains), monitor the impact of vaccines on disease, and advise on future vaccine development and the optimal schedule needed to control the disease.

To optimise a schedule, reduce the number of injections, and make space for other vaccines, reducing the schedule from a 3-dose to a 2-dose schedule in countries that have “mature” pneumococcal conjugate vaccine (PCV) programs and have pneumococcal vaccine-type disease controlled, could potentially improve the vaccine’s financial sustainability. This strategy is being pursued as part of a global PCV research agenda.

CRE-PDC addressed two outstanding research gaps for PCV use in the Asia-Pacific region:

  1. Country decisions regarding reduced dose PCV schedules (1+1), and
  2. Understanding serotype replacement following vaccine introduction.

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