Neonatal Research
Our team of experienced neonatologists, nurses, scientists, and engineers aim to improve the treatments and outcomes of ill newborn infants.
The research team includes world leaders in the fields of advanced respiratory therapies, resuscitation, neonatal neurology (including neuroimaging and bedside neuro-investigative tools), and congenital problems requiring surgery in early life.
Researchers use diverse research techniques from advanced molecular science and high-fidelity translational physiology recordings and imaging through to large randomised clinical trials and longitudinal developmental outcome studies to achieve our aims.
We pioneered many of our techniques at the Murdoch Children's Research Institute and are not available anywhere else.
Our work deepens our understanding of the fundamental principles relating to critical times in childhood, specifically the transition from fetal to ex-utero life through to long-term neurodevelopmental outcomes. This work has led to new advanced concepts and therapies that have improved the long-term outcomes of our most vulnerable population.
Group Leaders
Team Leaders
Group Members
Our projects
Gaps in the CDH Journey
This project is now completed. The Gaps in the CDH Journey project will identify questions and priorities of people with a lived experience of Congenital Diaphragmatic Hernia (CDH), their caregivers, and healthcare providers.
Read more...Optimising lung protective ventilation
Neonatal research is a leading international group researching the support and protection of the diseased newborn lung requiring mechanical ventilation, particularly advanced modalities such as high-frequency ventilation. They are recognised as world leaders in the field of physiological techniques for measuring and imaging regional lung function at the bedside, and thus, provide feedback to clinicians treating sick infants. This work has shown how important it is to carefully expand the sick infants lungs to a maximum level and then reduce the pressure to the lowest that will maintain optimal ventilation.
Improving the resuscitation of sick newborn infants at birth.
A healthy start to life involves the successful transition from in-utero to ex-utero life. For some newborn infants, this does not occur and they require resuscitation at birth. Members of our group have been undertaking a series of translational and clinical trials examining methods of improving newborn resuscitation. This work, funded by a National Health and Medical Research Council project grant in collaboration with Monash University and the Royal Women's Hospital, has improved the way neonatologists resuscitate sick newborn infants.
NEST (Newborn Electrographic Seizure Trial)
This multi-centre randomised controlled trial (RCT) is nearing completion and investigated the potential benefits and harms of treating all electrographic seizures in a cohort of encephalopathic term newborns.
PAEAN Study
In this study, the value of erythropoietin as an add-on therapy to therapeutic hypothermia for term infants with hypoxic-ischaemic encephalopathy is being investigated.
Other Studies include:
- RESUS NHMRC trial
- Molecular Lung Injury work
- Novel nebulisations systems
- Go with the Flow Study
- Temperature Control
- Developmental Outcomes of Complex Conditions
Funding
- National Health and Medical Research Council
- Centre of Research Excellence Program
- NHMRC Project Grant (Professor Hunt)
- NHMRC Career Development Fellowship (A/Prof Tingay)
- ANZ Trustees
- Cerebral Palsy Alliance
- Victorian Government Department of Business and Innovation
Collaborations
- NHMRC Preterm Infants Centre of Research Excellence
- The Royal Children’s Hospital, Melbourne
- The University of Melbourne
- Royal Women’s Hospital, Melbourne
- University of Western Australia
- Royal Hobart Hospital
- Monash University
- Politecnico Di Milano, Milan, Italy
- Carleton University, Ottawa, Canada
- Universitatsklinikum Schleswig-Holstein, Kiel, Germany
Featured publications
- Dance PREEMIE, a Dance PaRticipation intervention for Extremely prEterm children with Motor Impairment at prEschool age: an Australian feasibility trial protocol. 2020
- High Blood Pressure in Young Adult Survivors Born Extremely Preterm or Extremely Low Birthweight in the Post Surfactant Era. 2020
- Using Facebook to Improve Participation Among 25-Year-Olds Enrolled in a Longitudinal Preterm Birth Cohort Study. 2020
- A dedicated respiratory function monitor to improve tidal volume delivery during neonatal anaesthesia. 2019
- Antenatal and postnatal corticosteroids: A swinging pendulum. 2019