Our laboratory studies cell signalling to understand the driving forces behind complex human diseases.

Cells rely on a biochemical process called phosphorylation to respond to the environment and to engage in numerous biological functions. Phosphorylation is therefore an important mechanism that underpins almost all cellular behaviour. Over the last decade, powerful new technologies using mass spectrometry have emerged that now make it possible to measure cellular phosphorylation at a genome-wide scale.

In our lab, we use these mass spectrometry technologies to explore how cells behave in both healthy and disease contexts. By studying phosphorylation in this way, we can obtain unique insights into how cells function differently during disease. This information can help uncover how human diseases arise and discover effective new therapies to treat them.