Prof Enzo Porrello
Prof Enzo Porrello
Details
Role
Theme Director - Stem Cell Medicine
Research area
Stem Cell Medicine
Group
Heart Regeneration
Professor Porrello is the Theme Director of Stem Cell Medicine and Head of the Heart Regeneration group at the Murdoch Children’s Research Institute (MCRI). He also directs the Melbourne Node of the recently established Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW) and he is the founding Co-Director of the Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine (CardioRegen). Professor Porrello’s research focuses on the development of regenerative therapies for children and adults with heart failure. Throughout his career, he has made important contributions to our understanding of mammalian heart regeneration and has pioneered the development of human organoids for drug discovery. Professor Porrello is a co-founder of Dynomics, a biotechnology company focused on the development of new heart failure treatments using organoid technologies.
After completing his PhD in Physiology at the University of Melbourne, Professor Porrello was awarded an NHMRC/NHF C.J. Martin Fellowship to undertake postdoctoral training in Prof Eric Olson's laboratory at UT Southwestern Medical Center in Dallas, USA. Upon returning to Australia in 2012, Professor Porrello established the Cardiac Regeneration Laboratory at The University of Queensland, which he co-headed together with Dr James Hudson from 2013-2017.
After completing his PhD in Physiology at the University of Melbourne, Professor Porrello was awarded an NHMRC/NHF C.J. Martin Fellowship to undertake postdoctoral training in Prof Eric Olson's laboratory at UT Southwestern Medical Center in Dallas, USA. Upon returning to Australia in 2012, Professor Porrello established the Cardiac Regeneration Laboratory at The University of Queensland, which he co-headed together with Dr James Hudson from 2013-2017.
Professor Porrello is the Theme Director of Stem Cell Medicine and Head of the Heart Regeneration group at the Murdoch Children’s Research Institute (MCRI). He also directs the Melbourne Node of the recently established Novo Nordisk Foundation...
Professor Porrello is the Theme Director of Stem Cell Medicine and Head of the Heart Regeneration group at the Murdoch Children’s Research Institute (MCRI). He also directs the Melbourne Node of the recently established Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW) and he is the founding Co-Director of the Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine (CardioRegen). Professor Porrello’s research focuses on the development of regenerative therapies for children and adults with heart failure. Throughout his career, he has made important contributions to our understanding of mammalian heart regeneration and has pioneered the development of human organoids for drug discovery. Professor Porrello is a co-founder of Dynomics, a biotechnology company focused on the development of new heart failure treatments using organoid technologies.
After completing his PhD in Physiology at the University of Melbourne, Professor Porrello was awarded an NHMRC/NHF C.J. Martin Fellowship to undertake postdoctoral training in Prof Eric Olson's laboratory at UT Southwestern Medical Center in Dallas, USA. Upon returning to Australia in 2012, Professor Porrello established the Cardiac Regeneration Laboratory at The University of Queensland, which he co-headed together with Dr James Hudson from 2013-2017.
After completing his PhD in Physiology at the University of Melbourne, Professor Porrello was awarded an NHMRC/NHF C.J. Martin Fellowship to undertake postdoctoral training in Prof Eric Olson's laboratory at UT Southwestern Medical Center in Dallas, USA. Upon returning to Australia in 2012, Professor Porrello established the Cardiac Regeneration Laboratory at The University of Queensland, which he co-headed together with Dr James Hudson from 2013-2017.
Top Publications
- Sim, CB, Phipson, B, Ziemann, M, Rafehi, H, Mills, RJ, Watt, KI, Abu-Bonsrah, KD, Kalathur, RKR, Voges, HK, Dinh, DT, et al. Sex-Specific Control of Human Heart Maturation by the Progesterone Receptor.. Circulation 143(16) : 1614 -1628 2021 view publication
- Mills, RJ, Parker, BL, Quaife-Ryan, GA, Voges, HK, Needham, EJ, Bornot, A, Ding, M, Andersson, H, Polla, M, Elliott, DA, et al. Drug Screening in Human PSC-Cardiac Organoids Identifies Pro-proliferative Compounds Acting via the Mevalonate Pathway.. Cell Stem Cell 24(6) : 895 -907.e6 2019 view publication
- Mills, RJ, Titmarsh, DM, Koenig, X, Parker, BL, Ryall, JG, Quaife-Ryan, GA, Voges, HK, Hodson, MP, Ferguson, C, Drowley, L, et al. Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest.. Proc Natl Acad Sci U S A 114(40) : E8372 -E8381 2017 view publication
- Quaife-Ryan, GA, Sim, CB, Ziemann, M, Kaspi, A, Rafehi, H, Ramialison, M, El-Osta, A, Hudson, JE, Porrello, ER. Multicellular Transcriptional Analysis of Mammalian Heart Regeneration.. Circulation 136(12) : 1123 -1139 2017 view publication
- Porrello, ER, Mahmoud, AI, Simpson, E, Hill, JA, Richardson, JA, Olson, EN, Sadek, HA. Transient regenerative potential of the neonatal mouse heart.. Science 331(6020) : 1078 -1080 2011 view publication
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