Dr Sean Humphrey
Dr Sean Humphrey
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Available for student supervision
Dr Humphrey is Head of the Functional Phosphoproteomics Laboratory at the Murdoch Children’s Research Institute (MCRI). His research focuses on applying mass spectrometry technologies to identify new treatments for childhood diseases. Throughout his career, he has made important contributions to our understanding of cell signalling networks, has pioneered mass spectrometry-based methods for studying global signalling (‘phosphoproteomics’), and has applied these methods to diverse biological fields.
After completing his PhD in Biochemistry at the University of New South Wales, Dr Humphrey was awarded a prestigious EMBO postdoctoral fellowship and undertook post-doctoral training with Professor Matthias Mann at the Max Planck Institute of Biochemistry (Martinsried, Germany). Dr Humphrey has co-authored several landmark studies in phosphoproteomics, including the first time-resolved analyses of insulin signalling, and circadian rhythms in vivo, and is the recipient of the 2023 Peter Doherty Award and the 2024 Commonwealth Health Minister’s Award for the top-ranked NHMRC Investigator Grant in Australia.
After completing his PhD in Biochemistry at the University of New South Wales, Dr Humphrey was awarded a prestigious EMBO postdoctoral fellowship and undertook post-doctoral training with Professor Matthias Mann at the Max Planck Institute of Biochemistry (Martinsried, Germany). Dr Humphrey has co-authored several landmark studies in phosphoproteomics, including the first time-resolved analyses of insulin signalling, and circadian rhythms in vivo, and is the recipient of the 2023 Peter Doherty Award and the 2024 Commonwealth Health Minister’s Award for the top-ranked NHMRC Investigator Grant in Australia.
Dr Humphrey is Head of the Functional Phosphoproteomics Laboratory at the Murdoch Children’s Research Institute (MCRI). His research focuses on applying mass spectrometry technologies to identify new treatments for childhood diseases. Throughout his...
Dr Humphrey is Head of the Functional Phosphoproteomics Laboratory at the Murdoch Children’s Research Institute (MCRI). His research focuses on applying mass spectrometry technologies to identify new treatments for childhood diseases. Throughout his career, he has made important contributions to our understanding of cell signalling networks, has pioneered mass spectrometry-based methods for studying global signalling (‘phosphoproteomics’), and has applied these methods to diverse biological fields.
After completing his PhD in Biochemistry at the University of New South Wales, Dr Humphrey was awarded a prestigious EMBO postdoctoral fellowship and undertook post-doctoral training with Professor Matthias Mann at the Max Planck Institute of Biochemistry (Martinsried, Germany). Dr Humphrey has co-authored several landmark studies in phosphoproteomics, including the first time-resolved analyses of insulin signalling, and circadian rhythms in vivo, and is the recipient of the 2023 Peter Doherty Award and the 2024 Commonwealth Health Minister’s Award for the top-ranked NHMRC Investigator Grant in Australia.
After completing his PhD in Biochemistry at the University of New South Wales, Dr Humphrey was awarded a prestigious EMBO postdoctoral fellowship and undertook post-doctoral training with Professor Matthias Mann at the Max Planck Institute of Biochemistry (Martinsried, Germany). Dr Humphrey has co-authored several landmark studies in phosphoproteomics, including the first time-resolved analyses of insulin signalling, and circadian rhythms in vivo, and is the recipient of the 2023 Peter Doherty Award and the 2024 Commonwealth Health Minister’s Award for the top-ranked NHMRC Investigator Grant in Australia.
Top Publications
- Oliinyk, D, Will, A, Schneidmadel, FR, Böhme, M, Rinke, J, Hochhaus, A, Ernst, T, Hahn, N, Geis, C, Lubeck, M, et al. µPhos: a scalable and sensitive platform for high-dimensional phosphoproteomics.. Mol Syst Biol 20(8) : 972 -995 2024 view publication
- Xiao, D, Lin, M, Liu, C, Geddes, TA, Burchfield, JG, Parker, BL, Humphrey, SJ, Yang, P. SnapKin: a snapshot deep learning ensemble for kinase-substrate prediction from phosphoproteomics data.. NAR Genom Bioinform 5(4) : lqad099 2023 view publication
- Rudraraju, R, Gartner, MJ, Neil, JA, Stout, ES, Chen, J, Needham, EJ, See, M, Mackenzie-Kludas, C, Yang Lee, LY, Wang, M, et al. Parallel use of human stem cell lung and heart models provide insights for SARS-CoV-2 treatment.. Stem Cell Reports 18(6) : 1308 -1324 2023 view publication
- Fazakerley, DJ, van Gerwen, J, Cooke, KC, Duan, X, Needham, EJ, Díaz-Vegas, A, Madsen, S, Norris, DM, Shun-Shion, AS, Krycer, JR, et al. Phosphoproteomics reveals rewiring of the insulin signaling network and multi-nodal defects in insulin resistance.. Nat Commun 14(1) : 923 2023 view publication
- Diaz-Vegas, A, Norris, DM, Jall-Rogg, S, Cooke, KC, Conway, OJ, Shun-Shion, AS, Duan, X, Potter, M, van Gerwen, J, Baird, HJ, et al. A high-content endogenous GLUT4 trafficking assay reveals new aspects of adipocyte biology.. Life Sci Alliance 6(1) : 2023 view publication
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