photo of Dr Sean Humphrey

Dr Sean Humphrey

Dr Sean Humphrey

Details

Role Group Leader / Principal Research Fellow
Group Functional Phosphoproteomics
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Top Publications

  • Sacco, F, Humphrey, SJ, Cox, J, Mischnik, M, Schulte, A, Klabunde, T, Schäfer, M, Mann, M. Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion. Nature Communications 7(1) : 13250 2024
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  • Domanova, W, Krycer, J, Chaudhuri, R, Yang, P, Vafaee, F, Fazakerley, D, Humphrey, S, James, D, Kuncic, Z. Unraveling Kinase Activation Dynamics Using Kinase-Substrate Relationships from Temporal Large-Scale Phosphoproteomics Studies. PLOS ONE 11(6) : e0157763 2024
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  • Fazakerley, DJ, Chaudhuri, R, Yang, P, Maghzal, GJ, Thomas, KC, Krycer, JR, Humphrey, SJ, Parker, BL, Fisher-Wellman, KH, Meoli, CC, et al. Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance. eLife 7: e32111 2024
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  • Su, Z, Burchfield, JG, Yang, P, Humphrey, SJ, Yang, G, Francis, D, Yasmin, S, Shin, S-Y, Norris, DM, Kearney, AL, et al. Global redox proteome and phosphoproteome analysis reveals redox switch in Akt. Nature Communications 10(1) : 5486 2024
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  • Kearney, AL, Norris, DM, Ghomlaghi, M, Wong, MKL, Humphrey, SJ, Carroll, L, Yang, G, Cooke, KC, Yang, P, Geddes, TA, et al. Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis. eLife 10: e66942 2024
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