photo of A/Prof Silvia Velasco

A/Prof Silvia Velasco

A/Prof Silvia Velasco

Details

Role Group Leader / Principal Research Fellow
Group Neural Stem Cells

Contact

Available for student supervision
Using advanced pluripotent stem cell-derived 3D models of the human brain to study and identify new therapeutic approaches for neurodevelopmental disorders.

Our lab is interested in understanding the cellular and molecular basis of human brain development and disease by using pluripotent stem-cell derived 3D brain organoid models which closely mimic the cellular complexity, tissue architecture and connectivity of the developing human brain.

Human brain development largely occurs in utero and is therefore inaccessible for investigation. Most of what we know about this process comes from studies in rodents. However, many aspects of human brain development reflect species-specific events that cannot be fully investigated in other model organisms. The recent emergence of cellular models of the human brain, in the form of 3D brain organoids, represents a significant advance in modelling human brain development in vitro and provides an opportunity to understand how abnormalities in this process lead to neurodevelopmental disorders, a large group of conditions which include autism spectrum disorder, intellectual disability, attention deficit hyperactivity disorder, and infantile epilepsies. Current treatments for these conditions often aim at lifelong symptom management, a strategy necessitated by a lack of knowledge of the underlying causes.

By combining advanced 3D brain organoids and innovative high-throughput single-cell genomic and transcriptomic technologies, our lab aims to gain insights into cell-type specific developmental abnormalities associated with neurodevelopmental disorders, to ultimately identify novel effective treatments for children affected by these conditions.
Using advanced pluripotent stem cell-derived 3D models of the human brain to study and identify new therapeutic approaches for neurodevelopmental disorders.

Our lab is interested in understanding the cellular and molecular basis of human brain...
Using advanced pluripotent stem cell-derived 3D models of the human brain to study and identify new therapeutic approaches for neurodevelopmental disorders.

Our lab is interested in understanding the cellular and molecular basis of human brain development and disease by using pluripotent stem-cell derived 3D brain organoid models which closely mimic the cellular complexity, tissue architecture and connectivity of the developing human brain.

Human brain development largely occurs in utero and is therefore inaccessible for investigation. Most of what we know about this process comes from studies in rodents. However, many aspects of human brain development reflect species-specific events that cannot be fully investigated in other model organisms. The recent emergence of cellular models of the human brain, in the form of 3D brain organoids, represents a significant advance in modelling human brain development in vitro and provides an opportunity to understand how abnormalities in this process lead to neurodevelopmental disorders, a large group of conditions which include autism spectrum disorder, intellectual disability, attention deficit hyperactivity disorder, and infantile epilepsies. Current treatments for these conditions often aim at lifelong symptom management, a strategy necessitated by a lack of knowledge of the underlying causes.

By combining advanced 3D brain organoids and innovative high-throughput single-cell genomic and transcriptomic technologies, our lab aims to gain insights into cell-type specific developmental abnormalities associated with neurodevelopmental disorders, to ultimately identify novel effective treatments for children affected by these conditions.

Top Publications

  • Velasco, S, Paulsen, B, Arlotta, P. Highly reproducible human brain organoids recapitulate cerebral cortex cellular diversity.. 2019
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  • Velasco, S, Kedaigle, AJ, Simmons, SK, Nash, A, Rocha, M, Quadrato, G, Paulsen, B, Nguyen, L, Adiconis, X, Regev, A, et al. Individual brain organoids reproducibly form cell diversity of the human cerebral cortex. Nature 570(7762) : 523 -527 2019
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  • Uzquiano, A, Kedaigle, AJ, Pigoni, M, Paulsen, B, Adiconis, X, Kim, K, Faits, T, Nagaraja, S, Antón-Bolaños, N, Gerhardinger, C, et al. Single-cell multiomics atlas of organoid development uncovers longitudinal molecular programs of cellular diversification of the human cerebral cortex. 2022
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  • Paulsen, B, Velasco, S, Kedaigle, AJ, Pigoni, M, Quadrato, G, Deo, AJ, Adiconis, X, Uzquiano, A, Sartore, R, Yang, SM, et al. Autism genes converge on asynchronous development of shared neuron classes. Nature 602(7896) : 268 -273 2022
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  • Albanese, A, Swaney, JM, Yun, DH, Evans, NB, Antonucci, JM, Velasco, S, Sohn, CH, Arlotta, P, Gehrke, L, Chung, K. Multiscale 3D phenotyping of human cerebral organoids. Scientific Reports 10(1) : 21487 2020
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