photo of A/Prof Silvia Velasco

A/Prof Silvia Velasco

A/Prof Silvia Velasco

Details

Role Group Leader / Principal Research Fellow
Research area Stem cell biology

Contact

Available for student supervision
Using pluripotent stem cell-derived 3D models of the human brain to study and identify new therapeutic approaches for neurological disorders.

Our lab is interested in understanding the cellular and molecular basis of human brain diseases by using pluripotent stem-cell derived 3D brain organoids which reliably mimic processes of human brain development and disease in vitro.
Using pluripotent stem cell-derived 3D models of the human brain to study and identify new therapeutic approaches for neurological disorders.

Our lab is interested in understanding the cellular and molecular basis of human brain diseases by using...
Using pluripotent stem cell-derived 3D models of the human brain to study and identify new therapeutic approaches for neurological disorders.

Our lab is interested in understanding the cellular and molecular basis of human brain diseases by using pluripotent stem-cell derived 3D brain organoids which reliably mimic processes of human brain development and disease in vitro.

Top Publications

  • Velasco, S, Paulsen, B, Arlotta, P. Highly reproducible human brain organoids recapitulate cerebral cortex cellular diversity.. 2019
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  • Velasco, S, Kedaigle, AJ, Simmons, SK, Nash, A, Rocha, M, Quadrato, G, Paulsen, B, Nguyen, L, Adiconis, X, Regev, A, et al. Individual brain organoids reproducibly form cell diversity of the human cerebral cortex. Nature 570(7762) : 523 -527 2019
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  • Velasco, S. Modeling brain disorders using transplanted organoids: Beyond the short circuit. Cell Stem Cell 29(12) : 1617 -1618 2022
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  • Pigoni, M, Uzquiano, A, Paulsen, B, Kedaigle, A, Yang, SM, Symvoulidis, P, Adiconis, X, Velasco, S, Sartore, R, Kim, K, et al. Cell-type specific developmental defects in PTEN-mutant cortical organoids converge on abnormal circuit activity. 2022
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  • Uzquiano, A, Kedaigle, AJ, Pigoni, M, Paulsen, B, Adiconis, X, Kim, K, Faits, T, Nagaraja, S, Antón-Bolaños, N, Gerhardinger, C, et al. Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex. Cell 185(20) : 3770 -3788.e27 2022
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