photo of A/Prof Silvia Velasco

A/Prof Silvia Velasco

A/Prof Silvia Velasco

Details

Role Group Leader / Principal Research Fellow
Research area Stem Cell Medicine

Contact

Available for student supervision
Using pluripotent stem cell-derived 3D models of the human brain to study and identify new therapeutic approaches for neurological disorders.

Our lab is interested in understanding the cellular and molecular basis of human brain diseases by using pluripotent stem-cell derived 3D brain organoids which reliably mimic processes of human brain development and disease in vitro.
Using pluripotent stem cell-derived 3D models of the human brain to study and identify new therapeutic approaches for neurological disorders.

Our lab is interested in understanding the cellular and molecular basis of human brain diseases by...
Using pluripotent stem cell-derived 3D models of the human brain to study and identify new therapeutic approaches for neurological disorders.

Our lab is interested in understanding the cellular and molecular basis of human brain diseases by using pluripotent stem-cell derived 3D brain organoids which reliably mimic processes of human brain development and disease in vitro.

Top Publications

  • Velasco, S, Kedaigle, AJ, Simmons, SK, Nash, A, Rocha, M, Quadrato, G, Paulsen, B, Nguyen, L, Adiconis, X, Regev, A, et al. Individual brain organoids reproducibly form cell diversity of the human cerebral cortex.. Nature 570(7762) : 523 -527 2019
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  • Velasco, S, Paulsen, B, Arlotta, P. Highly reproducible human brain organoids recapitulate cerebral cortex cellular diversity.. 2019
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  • Velasco, S. Targeting RNA opens therapeutic avenues for Timothy syndrome.. Nature 628(8009) : 730 -732 2024
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  • Pigoni, M, Uzquiano, A, Paulsen, B, Kedaigle, AJ, Yang, SM, Symvoulidis, P, Adiconis, X, Velasco, S, Sartore, R, Kim, K, et al. Cell-type specific defects in PTEN-mutant cortical organoids converge on abnormal circuit activity.. Hum Mol Genet 32(18) : 2773 -2786 2023
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  • Velasco, S. Modeling brain disorders using transplanted organoids: Beyond the short circuit.. Cell Stem Cell 29(12) : 1617 -1618 2022
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