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Tuesday, April 21, 2015
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Hundreds of researchers and students at Murdoch Childrens Research Institute are doing everything in their power to uncover the causes and possible cures of childhood diseases. For some of us, our ‘power’ is tied up in how much computing power we have access to. Increasingly, new discoveries in medicine depend on the generation and analysis of huge data sets. One of the most well-known examples of this is the human genome project , in which over three billion ‘letters’ or nucleotides making up human DNA have been sequenced. Analysing such large data sets is clearly a mammoth task and in some cases is practically impossible without serious computational grunt. For this reason, MCRI has recently set up a high performance computing (HPC) resource. Simply put, an HPC is a collection of interconnected computers. Each souped-up computer is called a ‘node’ and these communicate with each other via an extremely fast...
Publication
Year: 
2014
Volume: 
21
Citation: 
Jarrod J Sandow., Loretta Dorstyn., Lorraine A O'Reilly., Maximilien Tailler., Sharad Kumar., Andreas Strasser., Paul G Ekert. ER stress does not cause up-regulation and activation of caspase-2 to initiate apoptosis. CELL DEATH AND DIFFERENTIATION 21 : 475 - 480(2014)
Publication
Year: 
2014
Volume: 
157
Issue: 
5
Citation: 
Rickard JA., O'Donnell JA., Evans JM., Lalaoui N., Poh AR., Rogers T., Vince JE., Lawlor KE., Ninnis RL., Anderton H., Hall C., Spall SK., Phesse TJ., Abud HE., Cengia LH., Corbin J., Mifsud S., Di Rago L., Metcalf D., Ernst M., Dewson G., Roberts AW., Alexander WS., Murphy JM., Ekert PG., Masters SL., Vaux DL., Croker BA., Gerlic M., Silke J. RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis. Cell 157 (5) : 1175 - 88(2014) PubMed
Publication
Year: 
2013
Volume: 
13
Citation: 
Bandopadhayay P., Jabbour AM., Riffkin C., Salmanidis M., Gordon L., Popovski D., Rigby L., Ashley DM., Watkins DN., Thomas DM., Algar E., Ekert PG. The oncogenic properties of EWS/WT1 of desmoplastic small round cell tumors are unmasked by loss of p53 in murine embryonic fibroblasts. BMC Cancer 13 : 585(2013) PubMed
Publication
Year: 
2013
Volume: 
20
Issue: 
10
Citation: 
Salmanidis M., Brumatti G., Narayan N., Green BD., van den Bergen JA., Sandow JJ., Bert AG., Silke N., Sladic R., Puthalakath H., Rohrbeck L., Okamoto T., Bouillet P., Herold MJ., Goodall GJ., Jabbour AM., Ekert PG. Hoxb8 regulates expression of microRNAs to control cell death and differentiation. CELL DEATH AND DIFFERENTIATION 20 (10) : 1370 - 80(2013) PubMed
Publication
Year: 
2013
Volume: 
11
Issue: 
3
Citation: 
Thomas D., Powell JA., Green BD., Barry EF., Ma Y., Woodcock J., Fitter S., Zannettino AC., Pitson SM., Hughes TP., Lopez AF., Shepherd PR., Wei AH., Ekert PG., Guthridge MA. Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival. PLoS biology 11 (3) : e1001515(2013) PubMed