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Dr Anneke Grobler
Anneke Grobler worked for 6 years as a statistician, and eventually group manager, for a Contract Research Organisation. In this position she obtained significant experience in analysing data using SAS® and designing clinical trials and data collection forms in various clinical areas; including oncology, central nervous system disorders and trauma. She has been working for 12 years as a statistician at an HIV/AIDS research organisation (CAPRISA), where she was the head of the statistics and data management departments. In this capacity she has been involved in study design, manuscript writing, protocol writing, grant application, analysis of randomised clinical trials and epidemiological data and database set-up and management as well as the management of about 13 staff members.
She was an evaluator for the clinical trials committee of the Medicines Control Council in South Africa (similar to the FDA in America) and is a current member of the Drug Trials Subcommittee of the ethics committee at the RCH.
Currently she works as a statistician at the Murdoch Childrens Research Institute (MCRI) at the Clinical Epidemiology and Biostatistics Unit (CEBU) and the University of Melbourne. Her role is to support clinical trials and observational studies carried out within the MCRI as well as at the RCH in Melbourne. She plays a major part in the design, planning, and statistical analysis for a range of clinical trials, including studies in Public Health, Health Services and Education. She is a member of the Melbourne Children's Trials Centre (MCTC). Her role includes statistical consultancy and providing training in clinical research, as well as mentoring PhD students and team members of the study teams she is part of. She also works with the Child Health CheckPoint wave of the Growing Up in Australia: The Longitudinal Study of Australian Children (LSAC) longitudinal cohort.
She obtained a PhD in statistics at the University of KwaZulu-Natal in 2014 with Geert Molenberghs from Belgium as a co-supervisor. She also holds a Master's degree in Biostatistics from Columbia University in the City of New York.
She has published 52 papers in peer reviewed journals such as Lancet, Lancet HIV, New England Journal of Medicine, Science.
Department of Paediatrics, University of Melbourne
Victorian Comprehensive Cancer Centre
2007: Columbia University Southern African Fogarty AITRP traineeship
2014: International Society of Clinical Biostatistics (ISCB) scientist award
She has a statistical research focus in the methods of multiple imputation for dealing with missing data.
Melbourne Childrens Trials Centre
Clinical Epidemiology and Biostatistics Unit
CHild Health CheckPoint
Kharsany A.B.M., Cawood C., Khanyile D., Grobler A., Mckinnon L.R., Samsunder N., Frohlich J.A., Abdool Karim Q., Puren A., Welte A., George G., Govender, K., Toledo C., Chipeta Z., Zembe L., Glenshaw M.T., Madurai L. Strengthening HIV Surveillance in the antiretroviral therapy era: Rationale and design of a longitudinal study to monitor HIV prevalence and incidence in the uMgungundlovu District, KwaZulu-Natal, South Africa. BMC Public Health, 2015.
Masson L., Passmore J-A., Liebenberg L.J., Werner L., Baxter C., Arnold K.B., Williamson C., … Grobler A., Abdool Karim Q., Abdool Karim S.S. Genital inflammation and the risk of HIV acquisition in women. Clinical Infectious Diseases, 61 (2), 260-269, 2015.
De Oliviera T., Kharsany A.B., Graf T., Cawood C., Khanyile D., Grobler A., Puren A., Madurai S., Baxter C., Karim Q.A., Karim S.S. Transmission networks and risk of HIV infection in KwaZulu-Natal, South Africa: a community-wide phylogenetic study. Lancet HIV. e41-e50. doi: 10.1016/S2352-3018(16)30186-2, 2017.
Klatt N.R, Cheu R., Birse K., Zevin A.S., Perner M., Noël-Romas L., Grobler A., Westmacott G., Xie I.Y., Butler J., Mansoor L., McKinnon L.R., Passmore J.S., Abdool Karim Q., Abdool Karim S.S, Burgner A.D. Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women. Science. 2017. Jun 2;356(6341):938-945. doi: 10.1126/science.aai9383. Pubmed ID: 28572388.
Grobler A., Cawood C., Khanyile D., Puren A., Kharsany A.B.M. Progress of UNAIDS 90-90-90 targets in a district in KwaZulu-Natal, South Africa, with high HIV burden, in the HIPSS study: a household-based complex multilevel community survey. Lancet HIV. 2017. Nov;4(11):e505-e513. doi: 10.1016/S2352-3018(17)30122-4. Epub 2017 Aug 2. Pubmed ID: 28779855
Kufa T., Kharsany A.B.M., Cawood C., Khanyile D., Lewis L., Grobler A., Chipeta Z., Bere A., Glenshaw M., Puren A. Misdiagnosis of HIV infection during a South African community-based survey: implications for rapid HIV testing. Journal of the International AIDS Society. 2017, 20(Suppl 6):21753. doi/10.7448/IAS.20.7.21753. PMCID: PMC5625550
Cutrell A., Donnell D., Dunn T.D., Glidden D.V., Grobler A., Hanscom B., Stancil B.S., Meyer R.D., Wang R., Cuffe R.L. HIV prevention trial design in an era of effective pre-exposure prophylaxis. HIV clinical trials. 2017, Nov-Dec;18(5-6):177-188. doi: 10.1080/15284336.2017.1379676. Pubmed ID: 29039265
Dlova N.C.,Chateau A.,Khoza N., Skenjane A.,Mkhize, Z., Katibi O.S., Grobler A., Gwegweni J.T., Mosam A. Prevalence of skin diseases treated at public referral hospitals in KwaZulu-Natal, South Africa. The British journal of dermatology. 2018, 178(1): e1-e2. DOI: 10.1111/bjd.15534 PMID: 28369695
Wang J., Sung V., Lycett K., Carew P., Liu R., Grobler A., Zubrick S., Olds T., Wake M., How body composition influences hearing status by mid-childhood and mid-life: The Longitudinal Study of Australian Children. International Journal of Obesity. 2018
Kharsany A.B.M., Cawood C.C., Khanyile D., Lewis L., Grobler A., Purin A., Govender K., George G., et.al., Community-based HIV prevalence in KwaZulu-Natal, South Africa: results of a cross-sectional household survey. The Lancet HIV. 2018 DOI:
Abdool Karim Q., Abdool Karim S.S., Frohlich J.A., Grobler A.C., Baxter C., Mansoor L.E., Kharsany A.B.M., Sibeko S., Mlisana K.P., Omar Z., Gengiah T.N., Maarschalk S., Arulappan N., Mlotshwa M., Morris L., Taylor D. (on behalf of the CAPRISA 004 Trial Group). Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in Women. Science, 2010, 329: 1168-1174
Grobler A., Abdool Karim S. Declining adherence is a more likely explanation than frailty of the apparent decline in efficacy in the CAPRISA 004 trial: response to O'Hagan et al. AIDS, 2012; 26: 2261-2265
Grobler A.C., Matthews G., Molenberghs G. The impact of missing data on clinical trials: a re-analysis of a placebo controlled trial of Hypericum perforatum (St Johns wort) and sertraline in major depressive disorder. Psychopharmacology, 2014, DOI 10.1007/s00213-013-3344-x
Padayatchi N., Abdool Karim S.S., Naidoo K., Grobler A., Friedland G. Improved survival in multidrug-resistant tuberculosis patients receiving integrated tuberculosis and antiretroviral treatmentin the SAPiT Trial. International Journal of Tuberculosis and Lung Disease, 2014, 18(2): 147-154
Drain P.K., Gounder L., Grobler A., Sahid F., Bassett I.V., Moosa M.-Y. Urine lipoarabinomannan to monitor antituberculosis therapy response and predict mortality in an HIV-endemic region: a prospective cohort study. BMJ Open, 2015.
Abdool Karim S.S., Abdool Karim Q., Kharsany A.B.M., Baxter C., Grobler A.C., Werner L., Kashuba A., Mansoor L.E., Samsunder N., Mindel A., Gengiah T.N. for the CAPRISA 004 trial group. Tenofovir gel for the prevention of Herpes Simplex viruss typ 2 infection. The New England Journal of Medicine, 2015.
Thrasher Research Fund: Determining the Impact of Penicillin on Latent Rheumatic Heart Disease, Statistician
Medical Research Future Fund, Lifting Clinical Trials and Registries Capacity, Delatycki M, Burns J, Corben L, Gobler A, Milne S, Lamont P, Liang C. The efficacy of rehabilitation for hereditary ataxias a randomized controlled trial. APP1152226 ($1,227,418.00) 2018-2020.