Dr Katherine Lee
A/Prof Katherine Lee is a senior biostatistician with over 15 years’ experience in the design, planning and analysis of randomised trials and observational studies. She is currently the Associate Director: Biostatistics of the Melbourne Children’s Trials Centre where she is the responsible statistician for 15 clinical trials and 5 observational studies being conducted at The Royal Children's Hospital. She has a Bachelor of Science in Mathematics from the University of Nottingham UK, a Masters of Science in Medical Statistics from the University of Leicester UK and a PhD in Biostatistics from the University of Cambridge.
Her methodological interest is in multiple imputation for dealing with missing data.
- Associate Director (Biostatistics), Melbourne Children's Trials Centre
- Honorary Fellow, Department of Paediatrics, University of Melbourne
- Poster Award – Eighth International Congress on Drug Therapy in HIV, 2006
- Student Conference Award – International Society for Clinical Biostatistics, 2005
- Scientific writing award – University of Cambridge, 2004
A/Prof Lee's main area of interest within the hospital is in the design and analysis of clinical trials. She is an active member of the team for a broad range of trials being carried out across the Melbourne Children's Campus. She also has a keen interest in preterm children, and in particular the longitudinal development of this at risk population.
A/Prof Lee also has a statistical research focus in the methods of multiple imputation for dealing with missing data. Her particular interest is in practical issues surrounding the implementation of this approach in the context of large longitudinal studies.
- Melbourne Children's Trials Centre
- Clinical Epidemiology and Biostatistics Unit
- Victorian Centre for Biostatistics (ViCBiostat)
- Victorian Infant Brain Studies (VIBeS)
Nguyen CD, Lee KJ, Carlin JB. Posterior predictive checking of multiple imputation models. Biom J. 2015 Jul;57(4):676-94.Sullivan TR, Salter AB, Ryan P and Lee KJ. Bias and precision of multiple imputation then deletion for dealing with missing outcome data. Accepted by American Journal of Epidemiology. 2015 Sep 15;182(6):528-34.
Lee KJ, Roberts G, Doyle LW, Anderson PJ, and Carlin JB. Multiple imputation for missing outcome data in a longitudinal cohort study: a detailed case study with guidance for practice. International Journal of Social Research Methodology.2016; 19 (5): 575-591.
Bines JE, Danchin M, Jackson P, Handley A, Watts E, Lee KJ, West A, Cowley D, Chen M, Barnes G, Justice F, Buttery J, Bishop R, Taylor B, Carlin JB, Kirkwood K for the RV3 Rotavirus Vaccine Program. Safety and Immunogenicity of RV3-BB Human Neonatal Rotavirus Vaccine administered as a birth or an infant dose schedule: A Randomised, Double Blind, Placebo-Controlled Trial. Lancet Infect Dis. 2015 Dec;15(12):1389-97.
Doyle LW, Cheong JLY, Burnett A, Roberts G, Lee KJ, and Anderson PJ for the Victorian Infant Collaborative Study Group. Biological and Social Influences on Outcomes of Extreme-Preterm/Low-Birth Weight Adolescents. Pediatrics. 2015 Dec;136(6):e1513-20.
Rezvan, PH, White IR, Lee KJ, Carlin JB and Simpson JA. Evaluation of a weighting approach for performing sensitivity analysis after multiple imputation. BMC Med Res Methodol. 2015 Oct 13;15:83.
Lee KJ and Carlin JB. Multiple imputation in the presence of non-normal data. Stats in Med, 2017; 36:606-617.
Yelland LN, Sullivan TR, Price DJ and Lee KJ. Sample Size Calculations for Randomised Trials Including Both Independent and Paired Data. Stats in Med 2017 Apr 15;36(8):1227-1239.
Sullivan TR, White IR, Salter AB, Ryan P and Lee KJ. Should multiple imputation be the method of choice for handling missing data in randomized trials?" Statistical Methods in Medical Research (2016), 962280216683570. https://doi.org/10.1177/0962280216683570.
Sullivan TR, Lee KJ, Ryan P and Salter AB. Multiple imputation for handling missing outcome data when estimating the relative risk. BMC Medical Research Methodology, 2017 Sep;17(1):134.
Bines JE, Thobari JA, Satria CD, Handley A, Watts E, Cowley D, Hera N, Ackland J, Standish J, Justice F, Byars G, Lee KJ, Barnes GL, Bachtair NS, Icanervilia AV, Boniface K, Bogdandovic-Sakran N, Pavlic D, Bishop RF, Kirkwood CD, Buttery JP and Soenarto Y. Human Neonatal Rotavirus Vaccine (RV3-BB) targets rotavirus from birth. N Engl J Med 2018; 378:719-730. DOI: 10.1056/NEJMoa1706804 .
Lee KJ and Carlin JC. Multiple Imputation for Missing Data: Fully Conditional Specification versus Multivariate Normal. American Journal of Epidemiology 2010 Mar; 1;171(5):624-32
Spittle AJ, Anderson PJ, Lee KJ, Ferretti C, Eeles A, Orton J, Boyd RN, Inder T, Doyle LW. Preventive care at home for very preterm infants improves infant and caregiver outcomes at 2 years. Pediatrics. 2010 Jul;126(1):e171-8
Doyle LW, Cheong J, Hunt R, Lee K, Thompson D, Davis PG, Rees S, Anderson PJ, Inder TE. Caffeine and brain development in very preterm infants. Ann Neurol. 2010 Nov;68(5):734-42
Lee KJ and Carlin JB. Recovery of information from multiple imputation: a simulation study. Emerging Themes in Epidemiology. 2012 Jun 13;9(1):3
Cheong JLY, Coleman L, Hunt RW, Lee KJ, Doyle LW, Inder TE, and Jacobs SE. Prognostic utility of magnetic resonance imaging in neonatal hypoxic-ischemic encephalopathy: substudy of a randomized trial. Archives of Pediatrics & Adolescent Medicine. 2012 Jul 1;166(7):634-40
Spencer-Smith MM, Spittle AJ, Doyle LW, Lee KJ, Lorefice L, Suetin A, Pascoe L, Anderson PJ. Long-term benefits of home-based preventative care for preterm infants: outcomes from a randomized trial. Pediatrics. 2012 Dec; 130(6): 1094-101
Lee KJ, Galati JC, Simpson JA and Carlin JB. Comparison of methods for imputing ordinal variables using the multivariate normal model in multiple imputation. Stats in Medicine. 2012 Dec 30; 31(30):4164-74
Carlin JB, Macartney K, Lee KJ, Quinn H, Buttery J, McIntyre P, Bines J. Rotavirus vaccination and risk of intussusception: case-series and case-control analysis of confirmed cases in Australia. Clinical Infection Diseases. 2013 Nov; 57(10):1427-34
Lee KL and Simpson JA. Introduction to multiple imputation for dealing with missing data. Respirology. 2014. Feb; 19(2):162-7.
Lee KJ and Carlin JB. Fractional polynomial adjustment for time-varying covariates in a self-controlled case series analysis. Stats in Med. 2014 Jan 15; 33(1):105-16
NHMRC Career Development Fellowship Level 1 - Integrated program of methodological and collaborative research (2013-2016) $238,634.
NHMRC Career Development Fellowship Level 2 - Biostatistical innovation and capacity building to advance child health and life-course epidemiology (2017-2020) $470,144.
Australian National Health and Medical Research Council (NHMRC) Project Grants:
- Primary prevention of infant food allergy: a randomised controlled trial of postnatal vitamin D supplementation (2018-2022). Allen K, Tang M, Ponsonby A, Lee KJ, Daziel K and Koplan J. $1,699,993.80
- Neurodevelopmental outcome after sevoflurane versus dexmedetomidine/remifentanil anaesthesia in infancy: a randomised controlled trial (2017-2021). Davidson A, Ungern-Sternberg BR, Hunt R, Crowe L, Lee KJ, McCann ME, McGowan F, Andropoulos D, Brambrink A, and Stargatt R. $825,787.40.
- Implementing multiple imputation with sensitivity analysis in large-scale longitudinal studies (2016-2018). Lee KJ, Carlin JC, Simpson JA, and White IR. $473,507.
- Motor trajectories of children born <30 weeks' gestation from birth to 5 years: early predictors and functional implications (2016-2019). Spittle A, Anderson PA, Doyle LW, McGinley J, Clarke R, Thompson D, Lee KJ and Cheong J. $687,068.10
- Does the treatment of anxiety in children with ADHD improve outcomes? A large-scale randomised controlled trial (2016-2019). Sciberras E, Hiscock H, Efron D and Lee KJ. $1,010,971.70
- Bell's Palsy in Children (BellPIC) (2015-2019). Babl F. Mackey M, Dalziel S, Oakley E, Borland M, Lee KJ, Davidson A, Herd D and Hopper S. $1,100,000.
- Executive dysfunction and brain development in very preterm children (2014-2016). Anderson P, Inder T, Doyle L, Neil J, Lee KJ and Spencer-Smith M. $712,272.80.
- A randomised controlled trial of a fluid containing 140mmol/L of sodium compared to a fluid containing 77mmol/L of sodium for maintenance intravenous fluid therapy in hospitalised children. (2012-2013). Davidson AJ, South M, Duke T, Lee KJ, Babl F, Young S. $180,192.
- The burden of late preterm birth on brain development and 2 year outcomes – a prospective, longitudinal cohort study (2012-2015). Cheong J, Anderson PA, Hunt R, Seal M, Lee KJ, Spittle A, Thompson D. $817,900
- Preventing Academic Difficulties In Preterm Children: An Adaptive Working Memory Training Intervention (2012-2015). Anderson P, Roberts G, Gathercole S, Nosarti C, Thompson D, Seal M, Lee KJ. $692,056.
- Practical tools for robust analysis of large epidemiological studies with incomplete data (2010-2012). Carlin JB, Simpson JA, Lee KJ. $352,242.
- Multi-site randomised controlled trial of fluoxetine in children and adolescents with autism (2010-2012). Reddihough D, Marraffa D, Hazell P, Lee KJ, Kohn M, Wray J, Virasinghe R. $490,979.