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Professor Igor Konstantinov
Professor Igor Konstantinov graduated from the Military Medical Academy, St. Petersburg, Russia in 1992. After completion his clinical training in Cardiothoracic Surgery in the world's leading institutions, that included the Mayo Clinic, Rochester, MN, USA and Hospital for Sick Children, Toronto, Canada, IK obtained PhD (2004) in molecular biology from the University of Toronto for his thesis titled “Gene Expression in Cardiac Surgery: Impact of Ischaemia and Re-perfusion". Prof Konstantinov held an academic appointment of Associate (2007-2008) and Adjunct (2008-2011) Professor of Surgery, University of Western Australia. Since 2008, Prof Konstantinov is Consultant Cardiothoracic Surgeon at the Royal Children's Hospital, Professor, University of Melbourne, and Senior Research Fellow of the Murdoch Children's Research Institute. Since 2015, he is Director of the National Paediatric Heart Transplantation Transcriptome Bank.
Consultant Cardiothoracic Surgeon, Royal Children's Hospital, Melbourne
Professor, University of Melbourne
Director, Melbourne Children's Centre for Cardiovascular Genomics and Regenerative Medicine
Professor Konstantinov published 275 papers, 112 in last 5 years (16 in 2012, 21 in 2013, 23 in 2014, 25 in 2015, 27 in 2016); H-index 32. Scopus citations 336 for the most quoted article and >100 for 5 articles. I wrote 12 book chapters (3 before 2012, 3 during 2012-13, and 6 in 2014-15) and 15 invited Editorials (9 in 2016). In 2016, Prof Konstantinov established and currently directs the National Paediatric Heart Transplantation Transcriptome Bank within the National Heart Transplantation Program in Children based at the Royal Children's Hospital in Melbourne. This is the world's first bank of such type and a major research initiative that permits a unique non-invasive assessment of rejection after heart transplantation in children. Prof Konstantinov co-directs Melbourne Children’s Centre for Cardiovascular Genomics and Regenerative Medicine, a major research initiative of the Murdoch Children’s Research Institute, University of Melbourne and the Royal Children’s Hospital
Prof Konstantinov's current major research themes include:
- Clinical application of remote ischemic preconditioning
- Molecular mechanisms of remote ischemic preconditioning
- Evaluation of inter-stage survival after stage 1 reconstruction of hypoplastic left heart syndrome
- Outcomes of double aortic arch repair
- Outcome of repair of pulmonary artery sling
- Long-term results of Taussig-Bing anomaly repair
- Long-term results of arterial switch operation
- Peri-operative cardio-pulmonary protection: its molecular mechanisms, genomic responses and clinical application
- Clinical outcome studies
- Clinical monitoring of rejection after heart transplantation
Top 5 publications in the last 5 years (* -senior author):
1. *Pepe S, et al. Effect of remote ischemic preconditioning on phosphorylated protein signaling in children undergoing tetralogy of Fallot repair. J Am Heart Assoc 2013 - First study describing the impact of ischemia on myocardial protein phosphorylation in children undergoing heart surgery.
2. Koay HF, et al. A three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage. Nat Immunol 2016 - First study to map the developmental pathway that control the generation of mucosal-associated invariant T cells in humans.
3. *Hepponstall M, et al. Remote ischemic preconditioning (RIPC) modifies plasma proteome in humans. PLoS One 2012 - First study describing global proteomic response to ischemia-reperfusion in humans.
4. *Shi WY, et al. Predictors of outcomes in children awaiting heart transplantation: an experience from a National Paediatric Heart Programme. Eur J Cardiothorac Surg 2016 - First national study of predictors of outcome in children awaiting heart transplantation in Australia.
5. *Shi WY, et al. Heart transplantation in Fontan patients across Australia and New Zealand. Heart 2016 - First bi-national study in children and young adult with single ventricle undergoing heart transplantation.