Dr Melanie Neeland
Role:
Research Fellow
Phone:
+61 (3) 8341 6493
Email:
Available for Student Supervision
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Dr Melanie Neeland
Biography:
Dr Melanie Neeland is a fellow of the NHMRC Centre of Excellence in Food and Allergy Research and currently leads the immunology research program of the Population Allergy and Respiratory groups at MCRI. Dr Neeland completed her PhD in vaccine immunology at Monash University in 2015. She is a recipient of a Melbourne Children's LifeCourse Fellowship, a Thrasher Research Fund Early Career Award and has recently returned from an invited Visiting Fellowship at the Sean N. Parker Center for Allergy & Asthma Research at Stanford University. Dr Neeland is an honorary fellow of the University of Melbourne Department of Paediatrics, where she co-supervises four postgraduate students and acts as a member of the Honours Committee.
Melanie has received $4.2 million in research funding as Chief Investigator to investigate the immune mechanisms contributing to the development of allergic and respiratory diseases. Melanie is a member of the inflammation network of the Chan Zuckerberg Initiative (CZI), the Australian Respiratory Early Surveillance Team for Cystic Fibrosis (AREST CF) Scientific Management Committee, and the International Trained Immunity Consortium.
Research:
Dr Neeland's research focuses on the immune mechanisms driving the development of childhood allergic, autoimmune and respiratory diseases. Specifically, her research aims to identify measurable, postnatal biomarkers associated with the development of disease and predictive of disease outcomes in later childhood. Melanie was recently awarded an NHMRC project grant, a Chan Zuckerberg Initaitive grant, and a postdoctoral fellowship to continue this work.
MR Neeland, S. Andorf... KC.Nadeau. Mass cytometry reveals cellular fingerprint associated with IgE+ peanut tolerance and allergy in early life. Nat Commun. 2020; 11(1):1091
S. Shanthikumar, M. Burton, S. Ranganathan, R. Saffery, MR Neeland. Single cell flow cytometry profiling of bronchoalveolar lavage in children. Am J Respir Cell Mol Biol. 2020 doi: 10.1165/rcmb.2019-0453MA
S. Imran, MR Neeland...B.Novakovic. Potential role for epigenetically mediated trained immunity in food allergy. iScience. 2020;23(6):101171.
S.Shanthikumar, MR Neeland, R Saffery, S Ranganathan. Gene modifiers of cystic fibrosis lung disease: A systematic revew. Paediatric Pulmonology 2019; 54(9):1356-1366.
MR Neeland...R Saffery, KJ Allen. B cell phenotype and function in infants with egg allergy. Allergy. 2019; 74(5):1022-1025.
DJ Martino, MR Neeland... R Saffery. Epigenetic dysregulation of naïve CD4 T cell activation genes in childhood food allergy. Nature Commun 2018; 9(1):3308
MR Neeland, JJ Koplin...KJ Allen. Early life innate immune signatures of persistent food allergy. J Allergy Clin Immunol 2018; 142(3): 857-864
KA Weissler, M Rasooly, T DiMaggio, H Bolan, D Cantave, D Martino, MR Neeland, ML Tang, TD Dang, KJ Allen, PA Guerrerio. Identification and analysis of peanut-specific effector and regulatory T cells in children allergic and tolerant to peanut. J Allergy Clin Immunol 2018. doi: 10.1016/j.jaci.2018.01.035
RL Peters, JJ Koplin. SC Dharmage, ML Tang, VL McWilliam, LC Gurrin, MR Neeland, AJ Lowe, AL Ponsonby, KJ Allen. Early exposure to cow's milk protein is associated with a reduced risk of cow's milk allergic outcomes. J Allergy Clin Immunol In Prac 2019; 7(2);462-470.
TD Dang, RL Peters, JJ Koplin, SC Dharmage, L Gurrin, AL Ponsonby, DJ Martino, MR Neeland, ML Tang, KJ Allen. Egg allergen specific IgE diversity predicts resolution of egg allergy in the population cohort HeathNuts. Allergy 2019; 74(2);318-326.
MR Neeland, W Shi, C Collignon, E Meeusen, AM Didierlaurent and MJ de Veer. The adjuvant system AS01 upregulates neutrophil CD14 expression and neutrophil-associated antigen transport in the local lymphatic network. Clin Exp Immunol 2018; 192(1):46-53.
RL Peters, MR Neeland and KJ Allen. Primary Prevention of Food Allergy. Curr Allergy Asthma Rep 2017; 17(8): 52.
MR Neeland, W Shi, C Collignon, N Taubenheim, E Meeusen, AM Didierlaurent and MJ de Veer. The lymphatic immune response induced by the adjuvant AS01: A comparison of intramuscular and subcutaneous immunisation routes. J. Immunol 2016; 197(7);2704-2714.
MR Neeland, DJ Martino and KJ Allen. The role of gene-environment interactions in the development of food allergy. Exp Rev Gastroenterol Hepatol 2015; 9 (11) 1371-1378.
MR Neeland, MJ Elhay, DR Powell, FJ Rossetto, E Meeusen and MJ de Veer. Transcriptional profile in afferent lymph cells following vaccination with liposomes incorporating CpG. Immunology 2015; 144 (3): 518-529.
MR Neeland, MJ Elhay, J Nathanielsz, E Meeusen and MJ de Veer. Incorporation of CpG into a Liposomal Vaccine Formulation Increases the Maturation of Antigen-Loaded Dendritic Cells and Monocytes to Improve Local and Systemic Immunity. J Immunol 2014; 192 (8): 3666-3675?
MR Neeland, MJ Elhay, E Meeusen and MJ de Veer. Vaccination with liposomal poly(I:C) induces discordant maturation of migratory dendritic cell subsets and anti-viral gene signatures in afferent lymph cells. Vaccine 2014; 32: 6183-6 192.
MR Neeland, E Meeusen and MJ de Veer. Afferent Lymphatic Cannulation as a Model System to Study Innate Immune Responses to Infection and Vaccination. Vet Immunol Immunopathol 2014; 158 (1-2): 86-97.
Funding:
NHMRC
Chan Zuckerberg Initiative
Thrasher Research Fund
NHMRC Centre for Food and Allergy Research
Sean N. Parker Center for Allergy & Asthma Research at Stanford University