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Dr Melanie Neeland
Dr Melanie Neeland leads an immunology research program investigating early life immune determinants of allergic and respiratory diseases. Dr Neeland completed her PhD in vaccine immunology at Monash University in 2015. She is a recipient of a Melbourne Children's LifeCourse Fellowship, a Thrasher Research Fund Early Career Award and held a Visiting Fellowship at Stanford University in 2017. Dr Neeland is an honorary fellow of the University of Melbourne Department of Paediatrics, where she co-supervises four postgraduate students and acts as a member of the Honours Committee.
Dr Neeland's research focuses on the immune mechanisms driving the development of childhood allergic, autoimmune and respiratory diseases. Specifically, her research aims to identify measurable, postnatal biomarkers associated with the development of disease and predictive of disease outcomes in later childhood. Melanie was recently awarded an NHMRC project grant, a Chan Zuckerberg Initiative grant, and a postdoctoral fellowship to continue this work.
Senior Author (original research)
S.Shanthikumar...M.R. Neeland. Processing of paediatric bronchoalveolar lavage samples for single cell analysis. Protocols.io 2021. dx.doi.org/10.17504/protocols.io.btiankae
S.Shanthikumar... M.R. Neeland. Application of high dimensional flow cytometry and unsupervised analysis to define the immune cell landscape of early childhood respiratory and blood compartments. BioRxiv:2021.03.21.436363.
S. Shanthikumar... M.R. Neeland. Single cell flow cytometry profiling of bronchoalveolar lavage in children. Am J Respir Cell Mol Biol. 2020; 63(2):152-159.
First Author (original research - past five years)
M.R. Neeland...R Saffery. Innate cell profiles during the acute and convalescent phase of SARS-CoV-2 infection in children. Nat Commun. 2021;12:1084
M.R. Neeland...R Saffery. Altered immune cell profiles and impaired CD4 T cell activation in single and multifood allergic adolescents. Clinical and Experimental Allergy 2021. Feb 24.
M.R. Neeland...S Andorf. Vitamin D insufficiency is associated with reduced regulatory T cell frequency in food allergic infants. Pediatric Allergy and Immunology 2020 Dec 22.
S Tosif*, M.R. Neeland*...N Crawford. Immune responses to SARS-CoV-2 in three children of parents with symptomatic COVID-19. Nat Commun. 2020;11;5703
M.R. Neeland...KC.Nadeau. Mass cytometry reveals cellular fingerprint associated with IgE+ peanut tolerance and allergy in early life. Nat Commun. 2020; 11(1):1091
M.R. Neeland...R Saffery. Hyper-inflammatory monocyte activation following endotoxin exposure in food allergic infants. Front. Immunol 2020; 11;567981
M.R. Neeland...KJ Allen. B cell phenotype and function in infants with egg allergy. Allergy. 2019; 74(5):1022-1025.
M.R. Neeland...KJ Allen. Early life innate immune signatures of persistent food allergy. J Allergy Clin Immunol 2018; 142(3): 857-864
M.R. Neeland...MJ de Veer. The adjuvant system AS01 upregulates neutrophil CD14 expression and neutrophil-associated antigen transport in the local lymphatic network. Clin Exp Immunol 2018; 192(1):46-53.
M.R. Neeland... MJ de Veer. The lymphatic immune response induced by the adjuvant AS01: A comparison of intramuscular and subcutaneous immunisation routes. J. Immunol 2016; 197(7);2704-2714.
M.R. Neeland...MJ de Veer. Transcriptional profile in afferent lymph cells following vaccination with liposomes incorporating CpG. Immunology 2015; 144 (3): 518-529.
Chan Zuckerberg Initiative
Thrasher Research Fund
NHMRC Centre for Food and Allergy Research
Sean N. Parker Center for Allergy & Asthma Research at Stanford University