Dr Melanie Neeland
Role:
Senior Research Officer
Phone:
+61 (3) 8341 6493
Email:
Available for Student Supervision
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Dr Melanie Neeland
Biography:
I am a senior research officer and principal investigator at the Murdoch Children’s Research Institute (MCRI). I obtained my PhD in immunology at Monash University in 2015, held an invited fellowship at Stanford University School of Medicine throughout 2017, and established my independent research program at MCRI in 2020. My research program aims to understand the immunological landscape of globally important childhood diseases, with key interest in the early life mechanisms driving pulmonary pathologies. I lead a team of 6 researchers and am lead principal investigator on two programs funded by the Chan Zuckerberg Initiative. I am a member of the scientific management committee of the Australian Respiratory Early Surveillance Team for Cystic Fibrosis (AREST-CF), the Chan Zuckerberg Initiative Inflammation and Pediatric Networks for the Human Cell Atlas, and the International Trained Immunity Consortium (INTRIM). I have made significant research contributions including the use of single cell approaches to identify targetable signatures of early life lung disease, persistent childhood allergy, and protective immunity in pediatric COVID-19.
Research:
Melanie’s research explores the single cell landscape of globally important childhood diseases with support from the NHMRC, the Chan Zuckerberg Initiative Inflammation Network and the Paediatric Networks for the Human Cell Atlas.
S.Shanthikumar...M.R. Neeland. Mapping pulmonary and systemic inflammation in preschool aged children with cystic fibrosis. Front Immunol 2021.
M.R. Neeland...N Crawford. Children and adults in a household cohort study have robust longitudinal immune responses following SARS-CoV-2 infection or exposure. Front Immunol 2021.
M.R. Neeland...R Saffery. Innate cell profiles during the acute and convalescent phase of SARS-CoV-2 infection in children. Nat Commun. 2021.
M.R. Neeland...R Saffery. Altered immune cell profiles and impaired CD4 T cell activation in single and multifood allergic adolescents. Clinical and Experimental Allergy 2021.
M.R. Neeland...S Andorf. Vitamin D insufficiency is assciated with reduced regulatory T cell frequency in food allergic infants. Pediatric Allergy and Immunology 2021.
S. Shanthikumar...M.R. Neeland. Single cell flow cytometry profiling of bronchoalveolar lavage in children. Am J Respir Cell Mol Biol. 2020.
S Tosif*, M.R. Neeland*...N Crawford. Immune responses to SARS-CoV-2 in three children of parents with symptomatic COVID-19. Nat Commun. 2020.
M.R. Neeland...KC.Nadeau. Mass cytometry reveals cellular fingerprint associated with IgE+ peanut tolerance and allergy in early life. Nat Commun. 2020.
M.R. Neeland...R Saffery. Hyper-inflammatory monocyte activation following endotoxin exposure in food allergic infants. Front. Immunol 2020.
M.R. Neeland...KJ Allen. B cell phenotype and function in infants with egg allergy. Allergy. 2019.
M.R. Neeland...KJ Allen. Early life innate immune signatures of persistent food allergy. J Allergy Clin Immunol 2018.
M.R. Neeland...MJ de Veer. The adjuvant system AS01 upregulates neutrophil CD14 expression and neutrophil-associated antigen transport in the local lymphatic network. Clin Exp Immunol 2018.
R Peters, M.R. Neeland, KJ Allen. Primary prevention of food allergy. Curr Allergy Asthma Rep 2017.
M.R. Neeland... MJ de Veer. The lymphatic immune response induced by the adjuvant AS01: A comparison of intramuscular and subcutaneous immunisation routes. J. Immunol 2016.
M.R. Neeland...MJ de Veer. Transcriptional profile in afferent lymph cells following vaccination with liposomes incorporating CpG. Immunology 2015.
Funding:
Chan Zuckerberg Initiative (Inflammation and Paediatric Networks for the Human Cell Atlas)
NHMRC
Thrasher Research Fund
NHMRC Centre for Food and Allergy Research
Sean N. Parker Center for Allergy & Asthma Research at Stanford University