Dr Melanie Neeland
Role:
Postdoctoral Research Fellow
Phone:
+61 (3) 8341 6493
Email:
Available for Student Supervision
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Dr Melanie Neeland
Biography:
Dr Melanie Neeland is a fellow of the NHMRC Centre of Excellence in Food and Allergy Research and currently leads the immunology research program of the Gastro & Food Allergy group at MCRI. Dr Neeland completed her PhD in immunology at Monash University in 2015. She is a recipient of a Thrasher Research Fund Early Career Award and has recently returned from an invited Visiting Fellowship at the Sean N. Parker Center for Allergy & Asthma Research at Stanford University. Dr Neeland is an honorary fellow of the University of Melbourne Department of Paediatrics, where she co-supervises?? two PhD students? and acts as a member of the Honours Committee.
Awards:
CASS Foundation International Travel Award (2018)
Journal of Allergy and Clinical Immunology Editors Choice (2017)
Thrasher Research Fund Early Career Award (2017)
Visting Fellow, Stanford University School of Medicine (April-July 2017)
European Academy of Allergy and Clinical Immunology International Travel Scholarship (2017)
NHMRC Centre of Excellence in Food and Allergy Research ECR Fellowship (2017)
Honorary Fellow, University of Melbourne Department of Paediatrics (2017)
MCRI Population Health Theme Early Career Fellowship (2016)
Research:
Dr Neeland's research focuses on the immune mechanisms drivin?g the development of childhood allergic disease. Specifically, her research aims to identify measurable, postnatal biomarkers associated with the development of food allergy and predictive of allergic disease outcomes in later childhood. Dr Neeland's research was amongst the first in the world to profile the innate immune response of food allergic infants and reveal assocations with disease outcomes (J. Allergy Clin Immunol 2017), and to characterise peanut-specific T cells in children allergic and tolerant to peanut (J. Allergy Clin Immunol 2018).
Projects:
HealthNuts
SchoolNuts
VITALITY
Centre for Food and Allergy Research
MR Neeland, JJ Koplin, TD Dang, SC Dharmage, ML Tang, SL Prescott, R Saffery, DJ Martino, KJ Allen. Early life innate immune signatures of persistent food allergy. J Allergy Clin Immunol 2017 doi: 10.1016/j.jaci.2017.10.024
KA Weissler, M Rasooly, T DiMaggio, H Bo?lan, D Cantave, D Martino, MR Neeland, ML Tang, TD Dang, KJ Allen, PA Guerrerio. Identification and analysis of peanut-specific effector and regulatory T cells in children allergic and tolerant to peanut. J Allergy Clin Immunol 2018. doi: 10.1016/j.jaci.2018.01.035
RL Peters, MR Neeland and KJ Allen. Primary Prevention of Food Allergy. Curr Allergy Asthma Rep 2017; 17(8): 52.
MR Neeland, DJ Martino and KJ Allen. The role of gene-environment interactions in the development of food allergy. Exp Rev Gastroenterol Hepatol 2015; 9 (11) 1371-1378.
MR Neeland, W Shi, C Collignon, E Meeusen, AM Didierlaurent and MJ de Veer. The adjuvant system AS01 upregulates neutrophil CD14 expression and neutrophil-associated antigen transport in the local lymphatic network. Clin Exp Immunol 2017 doi: 10.1111/cei.13088
MR Neeland, W Shi, C Collignon, N Taubenheim, E Meeusen, AM Didierlaurent and MJ de Veer. The lymphatic immune response induced by the adjuvant AS01: A comparison of intramuscular and subcutaneous immunisation routes. J. Immunol 2016; 197(7);2704-2714.
MR Neeland, MJ de Veer and JP Scheerlinck. Chapter 4: The role of antigen presentation and innate immunity during immune induction by particulate antigen. Micro and Nanotechnology in Vaccine Development 2016. Chapter Five; 75-85.
MR Neeland, MJ Elhay, DR Powell, FJ Rossetto, E Meeusen and MJ de Veer. Transcriptional profile in afferent lymph cells following vaccination with liposomes incorporating CpG. Immunology 2015; 144 (3): 518-529.
MR Neeland, MJ Elhay, J Nathanielsz, E Meeusen and MJ de Veer. Incorporation of CpG into a Liposomal Vaccine Formulation Increases the Maturation of Antigen-Loaded Dendritic Cells and Monocytes to Improve Local and Systemic Immunity. J Immunol 2014; 192 (8): 3666-3675?
MR Neeland, MJ Elhay, E Meeusen and MJ de Veer. Vaccination with liposomal poly(I:C) induces discordant maturation of migratory dendritic cell subsets and anti-viral gene signatures in afferent lymph cells. Vaccine 2014; 32: 6183-6 192.
MR Neeland, E Meeusen and MJ de Veer. Afferent Lymphatic Cannulation as a Model System to Study Innate Immune Responses to Infection and Vaccination. Vet Immunol Immunopathol 2014; 158 (1-2): 86-97?
M Burke, MJ de Veer, J Pleasance, MR Neeland, MJ Elhay, P Harrison and E Meeusen. Innate Immune Pathways in Afferent Lymph Following Vaccination with poly(I:C)-containing Liposomes. Innate Immunity 2014; 20: 501-510
MJ de Veer, MR Neeland, M Burke, J Pleasance, J Nathanielsz, MJ Elhay and E Meeusen. Cell Recruitment and Antigen Trafficking in Afferent Lymph after Injection of Antigen and poly(I:C) Containing Liposomes, in Aqueous or Oil-based Formulations. Vaccine 2013; 31: 1012-1018?
Funding:
Thrasher Research Fund
Centre for Food and Allergy Research
Sean N. Parker Center for Allergy & Asthma Research at Stanford University