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A/Professor Sebastian King
Associate Professor King is a paediatric surgeon with a subspecialty interest in colorectal conditions affecting neonates and children. He completed his PhD in 2008 with The University of Melbourne at The Royal Children's Hospital. His research focused upon the motility patterns of children affected by slow transit constipation. His PhD was supported by scholarships from the Royal Australasian College of Surgeons and the NHMRC.
Following completion of his paediatric surgical training at The Royal Children's Hospital, he underwent further colorectal and neonatal surgical training at Cincinnati Children's Hospital, USA and The Hospital for Sick Children, Toronto, Canada, before returning to Melbourne in 2015.
A/Prof. King's clinical role at The Royal Children's Hospital is now focused upon children born with anorectal malformations or Hirschsprung disease, and those affected by chronic constipation. A/Prof. King established the Complex Colorectal Service at The Royal Children's Hospital.
Colorectal Surgeon, Department of Paediatric Surgery, The Royal Children's Hospital
Consultant, Department of Clinical Nutrition, The Royal Children's Hospital
Associate Professor, Department of Paediatrics, University of Melbourne
2019 Basic Science Prize (co-author) – Australian New Zealand Paediatric Surgeons
2018 Australian of the Year Award nominee
2018 Basic Science Prize (co-author) – Pacific Association of Pediatric Surgeons
2016 Senior Lecturer Fellowship – Royal Australasian College of Surgeons
2014 Brian Smith Memorial Award – ANZ Trustees
2013 Career Development Award – Murdoch Children's Research Institute
2013 RCH Paediatric Handbook Travelling Scholarship – The Royal Children's Hospital
2013 Jeannie H Poolman Scholarship – The Royal Children's Hospital
2013 Hugh Johnston Travel Grant – Royal Australasian College of Surgeons
2012 Dr William Snowball Award – The Royal Children's Hospital
2006 John Ham Prize – Royal Australasian College of Surgeons
2006 Best Laboratory Paper (Paediatric Surgery) – Royal Australasian College of Surgeons
2005 Sir Edward Hughes Memorial Clinical Research Prize in Surgery
2005 Nate Myers Clinical Research Prize – Australian New Zealand Paediatric Surgeons
2005 Medical Post-Graduate Research Scholarship – NHMRC
2004 Peter King Foundation Scholarship – Royal Australasian College of Surgeons
2004 Scientist Scholarship – Murdoch Children's Research Institute
A/Prof. King's research is focused upon children born with anorectal malformations or Hirschsprung disease. In particular, he is interested in the long-term outcomes for affected children and their families, and the impact that poor intestinal motility has upon their quality of life. He collaborates with Dr Don Newgreen, Dr Lincon Stamp and Dr Simona Carbone to investigate the role of stem cell therapy for patients with Hirschsprung disease.
The other key component of A/Prof. King's research is the impact of abnormal colonic motility in children with chronic constipation, and children with abnormal oesophageal motility following repair of oesophageal atresia. His research has been supported by an MCRI Career Development Award, the Royal Australasian College of Surgeons Senior Lecturer Fellowship, the Royal Children's Hospital Foundation, and the NHMRC.
A/Prof. King has successfully supervised over 30 research students (MDRP, BMedSci, Honours) in the last 5 years.
Long-term outcomes in children born with anorectal malformations
Long-term outcomes in children born with Hirschsprung disease
Colonic motility patterns in children with chronic constipation
The role of stem cell therapy in Hirschsprung disease
Oesophageal motility patterns in children with oesophageal atresia
- "Paediatric Surgical Diagnosis: Atlas of Disorders of Surgical Significance" 2nd Edition 2018, Eds. Beasley SW, Hutson JM, Stringer M, King SK, Teague WJ. Published by CRC Press, Taylor and Francis Group, London
- "Jones Clinical Paediatric Surgery" 7th Edition 2015, Eds. Hutson JM, O'Brien M, Beasley SB, Teague WJ, King SK. Published by Wiley Blackwell, Oxford
Journal articles (selected)
- Kruger P, Teague WJ, Khanal R, Hutson JM, King SK. Delayed diagnosis of anorectal malformations in neonates. ANZ Journal of Surgery 2019 (in press)
- Trajanovska M, King SK, Goldfeld S, Gibb S. A novel method of rapid appraisal of clinical practice guidelines for children with enuresis. J Ped Urol 2019 DOI:10.1016/j.jpurol.2019.05.015
- Tan Tanny S, Comella A, Hutson JM, Omari T, Teague WJ, King SK. Quality of Life assessment tools for patients with Oesophageal Atresia – a focus on Long-Gap Oesophageal Atresia. J Pediatr Surg 2019 (in press)
- Kruger P, Teague WJ, Khanal R, Hutson JM, King SK. Screening for associated anomalies in anorectal malformations : the need for a standardised approach. ANZ Journal of Surgery 2019 DOI:10.1111/ans.15150
- Teague WJ, Jones MLM, Hawkey L, Smyth I, Catubig A, King SK, Sarila G, Li R, Hutson JM. FGF10 and the mystery of duodenal atresia in humans. Frontiers in Genetics 2018 DOI:10.3389/fgene.2018.00530
- Sood S, Lim R, Collins L, Trajanovska M, Hutson JM, Teague WJ, King SK. The long-term quality of life outcomes in adolescents with Hirschsprung disease. J Pediatr Surg 2018;53(12):2430-4.
- Jurkowicz B, Abu-Bonsrah D, Zhang D, Hutson JM, King SK, Newgreen D. Trans-serosal migration of enteric neural stem cells: developing an avian colon model. J Pediatr Surg 2018;53(12):2435-9.
- Ferris L, King SK, McCall L, Rommel N, Scholten I, Teague WJ, Doeltgen S, Omari T. Piecemeal deglutition and the implications for pressure impedance dysphagia assessment in pediatrics. J Pediatr Gastro Nutr 2018;67(6):713-9.
- GlobalSurg Collaborative. Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study. Lancet Infect Dis 2018;18(5):516-25.
- Collins L, Collis B, Trajanovska M, Khanal R, Hutson JM, Teague WJ, King SK. Quality of life outcomes in children with Hirschsprung disease. J Pediatr Surg DOI:10.1016/j.jpedsurg.2017.08.043
- King SK. Constipation – Surgical aspects, investigations and therapies. Current Pediatrics Reports 2017 DOI:10.1007/s40124-017-0126-7
- Burns AJ, Goldstein AM, Newgreen DF, Stamp L, Schafer K-H, Metzger M, Hotta R, Young HM, Andrews PA, Thapar N, Belkind-Gerson J, Bondurand N, Bornstein JC, Chan WY, Cheah K, Gershon MD, Heuckerath RO, Hofstra RMW, Just L, Kapur RP, King SK, McCann CJ, Nagy N, Ngan E, Obermayr F, Pachnis V, Pasricha PJ, Sham MH, Tam P, Vanden Berghe P. White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies. Developmental Biology 2016;417(2):229-51.
- Rollo B, Zhang D, Stamp L, Menheniott T, Stathopoulos L, Denham M, Dottori M, King SK, Hutson J, Newgreen D. Enteric neural cells from Hirschsprung disease patients form ganglia in autologous aneuronal colon muscle tissue. CMGH 2015;2(1):92-109.
- Levitt MA, King SK, Bischoff A, Alam S, Gonzalez G, Pena A. The Gonzalez hernia revisited: use of the ischiorectal fat pad to aid in the repair of rectovaginal and rectourethral fistulae. J Pediatr Surg 2014;49(8):1308-10.
- King SK, Sutcliffe JR, Ong S-Y, Lee M, Koh TL, Wong SQ, Farmer PJ, Peck CJ, Stanton MP, Keck J, Cook DJ, Chow CW, Hutson JM, Southwell BR. Substance P and vasoactive intestinal peptide are reduced in right transverse colon in paediatric slow transit constipation. Neurogastroenterol Motil 2010;22:883-e234
- King SK, Catto-Smith AG, Stanton MP, Sutcliffe JR, Simpson D, Cook I, Dinning PG, Hutson JM, Southwell BR. 24-hour colonic manometry in pediatric slow transit constipation shows significant reductions in antegrade propagation. Am J Gastroenterol 2008;103(8):2083-91.
RCH Foundation – Translational Research Academic Paediatric Surgeon