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MCRI welcomes $35m Federal grant for Strep A vaccine research to prevent deadly heart disease

Research News
Published: 
Monday, February 25, 2019 - 10:28am

The Murdoch Children’s Research Institute based in Melbourne will be a key partner in a $35 million national consortium formed to fast track a vaccine against Strep A, the highly contagious
bacterium that causes around 500,000 deaths every year.

The Federal Minister for Indigenous Health, Ken Wyatt, has today awarded $35 million to the Telethon Kids Institute in Perth to the lead the consortium, with MCRI a key partner.

MCRI infectious diseases professor Andrew Steer, who is a world expert in Strep A, said Aboriginal and Torres Strait Islander communities have one of the highest rates of Strep A disease
in the world.

“Strep A usually begins with a sore throat, but if left untreated it causes the immune system to become overactive, which can result in rheumatic heart disease, where antibodies damage the heart valves,” Prof Steer said.

“Globally Strep A is almost as deadly as malaria parasites, tuberculosis bacteria and HIV but internationally little has been invested in Strep A research. This funding is very welcome, because
with a new vaccine we could stop Strep A infections in Australia and around the world.”

MCRI will soon begin testing two new vaccines in human volunteers. MCRI has been working closely with the World Health Organisation to promote development of new vaccine candidates.

“In Australia 94 per cent of rheumatic heart disease occur among Indigenous Australians,” Prof Steer said.

“Globally rheumatic heart disease affects more than 33 million people, causing about 500,000 deaths. That is why it’s imperative we develop a vaccine.”

Prof Steer said Strep A also caused skin sores, septicemia (blood poisoning) and toxic shock syndrome.

“Rheumatic heart disease leads to serious complications such as stroke and premature death in young adults and even adolescents,” said Professor Jonathan Carapetis, Director of the Telethon
Kids Institute. “And while the disease is preventable, and treatable when found early, young people continue to die because it’s detected too late.”

Prof Carapetis said developing a Strep A vaccine could have a real impact on closing the gap in Indigenous heath in Australia.

Available for interview:

  • Professor Andrew Steer, MCRI

Prof Steer’s research into strep A was recently featured in the Mosaic Science magazine: https://mosaicscience.com/story/strep-throat-vaccine-vaccination-strepto...
gas-rhd-rheumatic-heart-disease/

Media Contact
Christine Tondorf - MCRI communications advisor (media/PR)
Ph: +613 9936 6197 | Mob: 0413 307 092
christine.tondorf@mcri.edu.au