FlexBio - Contract research platform for skeletal muscle analyses
- Project status: Active
Research area: Genomic Medicine > Muscle Research
FlexBio partners with academic and industry researchers to deliver comprehensive pre-clinical disease modelling and therapeutic screening services.
With over 15 years of expertise in both in vitro (tissue culture) and in vivo (pre-clinical mouse) skeletal muscle model analyses, we offer an end-to-end service that includes:
- Ethical and institutional approvals
- Complete data analysis packages
- Detailed, customisable reports
With over 15 years of expertise in both in vitro (tissue culture) and in vivo (pre-clinical mouse) skeletal muscle model analyses, we offer an end-to-end service that includes:
- Ethical and institutional approvals
- Complete data analysis packages ...
With over 15 years of expertise in both in vitro (tissue culture) and in vivo (pre-clinical mouse) skeletal muscle model analyses, we offer an end-to-end service that includes:
- Ethical and institutional approvals
- Complete data analysis packages
- Detailed, customisable reports
What we offer
Pre-clinical animal model testing
Screen and validate potential therapeutic candidates with key in vivo proof-of-concept data, including:
- Voluntary muscle function: Grip strength and wheel running assessments
- Isolated muscle function: Whole muscle, fibre bundle, or single fibre contractile function
- Nerve-evoked muscle function: Force generation assays to evaluate in situ muscle performance, damage susceptibility, and fatigue response.
2D & 3D Skeletal muscle modelling
Using induced pluripotent stem cell-derived muscle models, we offer advanced profiling in both healthy individuals and patients with genetically confirmed muscle diseases.
Available disease models include:
- Duchenne Muscular Dystrophy (DMD)
- Nemaline Myopathy
- Severe X-linked Myotubular Myopathy
- Collagen VI Muscular Dystrophy
- Facioscapulohumeral Muscular Dystrophy (FSHD)
Why FlexBio?
Our detailed disease modelling platforms provide a unique opportunity for collaborators to generate cutting-edge data that supports the development of therapies aimed at improving skeletal muscle function and performance.
Our research team
- Dr Peter Houweling, Team Leader at MCRI
- Dr Leon Kiriaev, Research Officer at MCRI
- Dr Ian Woodcock, Paediatric Neurologist at The Royal Children's Hospital (RCH)
Internationally recognised team of laboratory and clinical researchers with a combined 50 years experience in studying skeletal muscle. Over 50 scientific manuscripts, focused on skeletal muscle performance in health and disease and 20 International and National clinical trials to date.
Contact us
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