Stem Cell Biology

We are driving the development of therapies for currently incurable diseases, including kidney, heart and skeletal muscle diseases, leukemia, brain cancer, respiratory diseases and juvenile diabetes.

Stem Cell Biology Theme Leader Enzo Porrello

Our research

Using cutting-edge stem cell technologies, we seek to understand the causes of childhood diseases, screen for new treatments and advance regenerative medicine.

Our researchers are experts in stem cells, gene editing, transcriptomics, phosphoproteomics and bioengineering technologies that can be used to model complex disease mechanisms and develop new stem cell-based therapies.

The Theme encompasses research groups investigating diseases such as kidney, heart, blood, skeletal muscle and respiratory diseases, neurodevelopmental disorders, childhood cancers and diabetes. Our Stem Cell Ethics and Policy group contributes to the ethical, legal and social frameworks of stem cell research and related technologies.

Underpinning this expertise and driving innovation are our state-of-the-art stem cell facilities: the iPSC Derivation and Gene Editing Facility and Stem Cell Disease Modelling & Drug Screening Facility.

Image: Professor Enzo Porrello, Theme Director of Stem Cell Biology at the Murdoch Children's Research Institute.

Using cutting-edge stem cell technologies, we seek to understand the causes of childhood diseases, screen for new treatments and advance regenerative medicine.

Our researchers are experts in stem cells, gene editing, transcriptomics,...

Using cutting-edge stem cell technologies, we seek to understand the causes of childhood diseases, screen for new treatments and advance regenerative medicine.

Our researchers are experts in stem cells, gene editing, transcriptomics, phosphoproteomics and bioengineering technologies that can be used to model complex disease mechanisms and develop new stem cell-based therapies.

The Theme encompasses research groups investigating diseases such as kidney, heart, blood, skeletal muscle and respiratory diseases, neurodevelopmental disorders, childhood cancers and diabetes. Our Stem Cell Ethics and Policy group contributes to the ethical, legal and social frameworks of stem cell research and related technologies.

Underpinning this expertise and driving innovation are our state-of-the-art stem cell facilities: the iPSC Derivation and Gene Editing Facility and Stem Cell Disease Modelling & Drug Screening Facility.

Image: Professor Enzo Porrello, Theme Director of Stem Cell Biology at the Murdoch Children's Research Institute.

Stem Cell Biology groups

Blood Development

Improving the treatment of children with leukaemia and bone marrow failure who lack a suitable donor.

Explore Blood Development

Diabetes

Defining the impact of diabetes on the developing brain, mental health and quality of life.

Explore Diabetes

Heart Regeneration

Improving regenerative therapies for congenital and acquired forms of heart disease.

Explore Heart Regeneration

Heart Disease

Improving outcomes for children with complex forms of Childhood Heart Disease (CHD).

Explore Heart Disease

Immune Development

Developing new treatments for this lifelong condition, such as type 1 diabetes.

Explore Immune Development

Kidney Regeneration

Improving treatments for kidney diseases and developing replacement organs (mini kidneys).

Explore Kidney Regeneration

Muscle Bioengineering

Using stem cells to generate human bioengineered muscle, both skeletal muscle and heart muscle

Explore Muscle Bioengineering

Musculoskeletal

Improving the quality of life of children with skeletal disorders.

Explore Musculoskeletal

Neuro-oncology

Understanding the gene regulatory networks that control and are controlled by Dlx genes.

Explore Neuro-oncology

Neural Stem Cell

Using advanced pluripotent stem cell-derived 3D organoid models of the human brain.

Explore Neural Stem Cell

Stem Cell Ethics & Policy

Studying the ethical, legal and social implications of stem cell research and related technologies.

Explore Stem Cell Ethics & Policy

Transcriptomics & Bioinformatics

Mining our genomic information, in order to uncover the underlying genetic causes of congenital diseases, such as congenital heart disease (CHD).

Explore Transcriptomics & Bioinformatics