photo of Prof Andrew Elefanty

Prof Andrew Elefanty

Prof Andrew Elefanty

Details

Role Group Leader / Snr Princ Research Fellow
Research area Stem cell biology

Contact

Available for student supervision
Professor Andrew Elefanty is the Group Leader of the Blood Diseases Laboratory at the Murdoch Children’s Research Institute. Prof Elefanty's research focusses on differentiation of human pluripotent stem cells to understand and model blood diseases in vitro and for transplantation. Together with the laboratories of Professor Ed Stanley (Immune Development) and Dr Elizabeth Ng (Blood Development) at MCRI, Prof Elefanty has made important contributions to the generation of genetically modified human stem cell lines in which lineage-specific fluorescent reporters allow monitoring of differentiation.

After training as a physician, Prof Elefanty completed a PhD in leukaemogenesis at the Walter and Eliza Hall Institute of Medical Research supervised by Prof Suzanne Cory. He subsequently worked on globin gene regulation with Prof Frank Grosveld at the National Institute for Medical Research in Mill Hill, London before returning to the Hall Institute to pursue interests in developmental haematopoiesis and the differentiation of mouse embryonic stem cells. He moved to Monash University in 2002 to initiate studies with human embryonic stem cells. In 2013, his laboratory relocated to the Murdoch Children’s Research Institute. In collaboration with Dr Elizabeth Ng and Prof Ed Stanley, he has focused on haematopoietic differentiation of human pluripotent stem cells.

Prof Elefanty holds active collaborations with:
• Prof Ed Stanley, Immune Development Laboratory, Murdoch Children's Research Institute
• Dr Elizabeth Ng, Blood Development Laboratory, Murdoch Children's Research Institute
• Prof Constanze Bonifer, Institute of Cancer and Genomic Sciences, University of Birmingham
• Prof Hanna Mikkola, Department of Molecular, Cell and Developmental Biology University of California
Professor Andrew Elefanty is the Group Leader of the Blood Diseases Laboratory at the Murdoch Children’s Research Institute. Prof Elefanty's research focusses on differentiation of human pluripotent stem cells to understand and model blood diseases...
Professor Andrew Elefanty is the Group Leader of the Blood Diseases Laboratory at the Murdoch Children’s Research Institute. Prof Elefanty's research focusses on differentiation of human pluripotent stem cells to understand and model blood diseases in vitro and for transplantation. Together with the laboratories of Professor Ed Stanley (Immune Development) and Dr Elizabeth Ng (Blood Development) at MCRI, Prof Elefanty has made important contributions to the generation of genetically modified human stem cell lines in which lineage-specific fluorescent reporters allow monitoring of differentiation.

After training as a physician, Prof Elefanty completed a PhD in leukaemogenesis at the Walter and Eliza Hall Institute of Medical Research supervised by Prof Suzanne Cory. He subsequently worked on globin gene regulation with Prof Frank Grosveld at the National Institute for Medical Research in Mill Hill, London before returning to the Hall Institute to pursue interests in developmental haematopoiesis and the differentiation of mouse embryonic stem cells. He moved to Monash University in 2002 to initiate studies with human embryonic stem cells. In 2013, his laboratory relocated to the Murdoch Children’s Research Institute. In collaboration with Dr Elizabeth Ng and Prof Ed Stanley, he has focused on haematopoietic differentiation of human pluripotent stem cells.

Prof Elefanty holds active collaborations with:
• Prof Ed Stanley, Immune Development Laboratory, Murdoch Children's Research Institute
• Dr Elizabeth Ng, Blood Development Laboratory, Murdoch Children's Research Institute
• Prof Constanze Bonifer, Institute of Cancer and Genomic Sciences, University of Birmingham
• Prof Hanna Mikkola, Department of Molecular, Cell and Developmental Biology University of California

Top Publications

  • Calvanese, V, Capellera-Garcia, S, Ma, F, Fares, I, Liebscher, S, Ng, ES, Ekstrand, S, Aguadé-Gorgorió, J, Vavilina, A, Lefaudeux, D, et al. Mapping human haematopoietic stem cells from haemogenic endothelium to birth. Nature 604(7906) : 534 -540 2022
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  • Forte, E, Ramialison, M, Nim, HT, Mara, M, Li, JY, Cohn, R, Daigle, SL, Boyd, S, Stanley, EG, Elefanty, AG, et al. Adult mouse fibroblasts retain organ-specific transcriptomic identity. eLife 11: e71008 2022
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  • Tian, P, Elefanty, A, Stanley, EG, Durnall, JC, Thompson, LH, Elwood, NJ. Creation of GMP-Compliant iPSCs From Banked Umbilical Cord Blood. Frontiers in Cell and Developmental Biology 10: 835321 2022
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  • Sun, S, Li, JY, Nim, HT, Piers, A, Ramialison, M, Porrello, ER, Konstantinov, IE, Elefanty, AG, Stanley, EG. CD90 Marks a Mesenchymal Program in Human Thymic Epithelial Cells In Vitro and In Vivo. Frontiers in Immunology 13: 846281 2022
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  • Schnoeder, TM, Schwarzer, A, Jayavelu, AK, Hsu, C-J, Kirkpatrick, J, Döhner, K, Perner, F, Eifert, T, Huber, N, Arreba-Tutusaus, P, et al. PLCG1 is required for AML1-ETO leukemia stem cell self-renewal.. Blood 139(7) : 1080 -1097 2022
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