photo of Prof Andrew Elefanty

Prof Andrew Elefanty

Prof Andrew Elefanty

Details

Role Group Leader / Snr Princ Research Fellow
Research area Stem cell biology

Contact

Available for student supervision
Professor Andrew Elefanty is the Group Leader of the Blood Diseases Laboratory at the Murdoch Children’s Research Institute. Prof Elefanty's research focusses on differentiation of human pluripotent stem cells to understand and model blood diseases in vitro and for transplantation. Together with the laboratories of Professor Ed Stanley (Immune Development) and Dr Elizabeth Ng (Blood Development) at MCRI, Prof Elefanty has made important contributions to the generation of genetically modified human stem cell lines in which lineage-specific fluorescent reporters allow monitoring of differentiation.

After training as a physician, Prof Elefanty completed a PhD in leukaemogenesis at the Walter and Eliza Hall Institute of Medical Research supervised by Prof Suzanne Cory. He subsequently worked on globin gene regulation with Prof Frank Grosveld at the National Institute for Medical Research in Mill Hill, London before returning to the Hall Institute to pursue interests in developmental haematopoiesis and the differentiation of mouse embryonic stem cells. He moved to Monash University in 2002 to initiate studies with human embryonic stem cells. In 2013, his laboratory relocated to the Murdoch Children’s Research Institute. In collaboration with Dr Elizabeth Ng and Prof Ed Stanley, he has focused on haematopoietic differentiation of human pluripotent stem cells.

Prof Elefanty holds active collaborations with:
• Prof Ed Stanley, Immune Development Laboratory, Murdoch Children's Research Institute
• Dr Elizabeth Ng, Blood Development Laboratory, Murdoch Children's Research Institute
• Prof Constanze Bonifer, Institute of Cancer and Genomic Sciences, University of Birmingham
• Prof Hanna Mikkola, Department of Molecular, Cell and Developmental Biology University of California
Professor Andrew Elefanty is the Group Leader of the Blood Diseases Laboratory at the Murdoch Children’s Research Institute. Prof Elefanty's research focusses on differentiation of human pluripotent stem cells to understand and model blood diseases...
Professor Andrew Elefanty is the Group Leader of the Blood Diseases Laboratory at the Murdoch Children’s Research Institute. Prof Elefanty's research focusses on differentiation of human pluripotent stem cells to understand and model blood diseases in vitro and for transplantation. Together with the laboratories of Professor Ed Stanley (Immune Development) and Dr Elizabeth Ng (Blood Development) at MCRI, Prof Elefanty has made important contributions to the generation of genetically modified human stem cell lines in which lineage-specific fluorescent reporters allow monitoring of differentiation.

After training as a physician, Prof Elefanty completed a PhD in leukaemogenesis at the Walter and Eliza Hall Institute of Medical Research supervised by Prof Suzanne Cory. He subsequently worked on globin gene regulation with Prof Frank Grosveld at the National Institute for Medical Research in Mill Hill, London before returning to the Hall Institute to pursue interests in developmental haematopoiesis and the differentiation of mouse embryonic stem cells. He moved to Monash University in 2002 to initiate studies with human embryonic stem cells. In 2013, his laboratory relocated to the Murdoch Children’s Research Institute. In collaboration with Dr Elizabeth Ng and Prof Ed Stanley, he has focused on haematopoietic differentiation of human pluripotent stem cells.

Prof Elefanty holds active collaborations with:
• Prof Ed Stanley, Immune Development Laboratory, Murdoch Children's Research Institute
• Dr Elizabeth Ng, Blood Development Laboratory, Murdoch Children's Research Institute
• Prof Constanze Bonifer, Institute of Cancer and Genomic Sciences, University of Birmingham
• Prof Hanna Mikkola, Department of Molecular, Cell and Developmental Biology University of California

Top Publications

  • Schiesser, JV, Yu, Y, Loudovaris, T, Thomas, HE, Elefanty, AG, Stanley, EG. 336.3: Identification of novel cell surface markers for the characterization of human beta cell replacement therapies. Transplantation 107(10S2) : 135 -135 2023
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  • Vlahos, K, Sourris, K, Yi Kuah, J, Graham, A, Suter, A, Howden, SE, Stanley, EG, Elefanty, AG. Generation of iPSC lines from peripheral blood mononuclear cells from five healthy donors. Stem Cell Research 69: 103109 2023
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  • Lamandé, SR, Ng, ES, Cameron, TL, Kung, LHW, Sampurno, L, Rowley, L, Lilianty, J, Patria, YN, Stenta, T, Hanssen, E, et al. Modeling human skeletal development using human pluripotent stem cells. Proceedings of the National Academy of Sciences of the United States of America 120(19) : e2211510120 2023
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  • Sun, S, Wijanarko, K, Liani, O, Strumila, K, Ng, ES, Elefanty, AG, Stanley, EG. Lymphoid cell development from fetal hematopoietic progenitors and human pluripotent stem cells. Immunological Reviews 315(1) : 154 -170 2023
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  • Anderson, DJ, Kaplan, DI, Bell, KM, Koutsis, K, Haynes, JM, Mills, RJ, Phelan, DG, Qian, EL, Leitoguinho, AR, Arasaratnam, D, et al. NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network. Nature Communications 9(1) : 1373 2023
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