photo of Dr Antonia Zech

Dr Antonia Zech

Dr Antonia Zech

Details

Role Research Officer
Research area Stem Cell Medicine
Antonia (Toni) is a Research Officer at the Heart Regeneration and Disease group at the Murdoch Children’s Research Institute, which is part of the recently established Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW), Melbourne Node.

After completing her masters in Molecular Life Sciences at the University of Hamburg, Germany, Antonia started her PhD in the lab of Prof. Lucie Carrier at the University Medical Center Hamburg-Eppendorf, Germany, where she investigated the autophagy-lysosomal pathway in human inherited cardiomyopathies. During her PhD, Antonia developed a strong affinity for stem cell research using human induced pluripotent stem cell-derived cardiomyocytes as a model of disease to evaluate disease pathomechanism of cardiomyopathies. After receiving her PhD in 2020, Antonia was awarded with a postdoc grant from the Research Promotion Fund of the Faculty of Medicine, University Medical Center Hamburg-Eppendorf, Germany, to finalize her projects. In 2022, she joined the lab of Prof. Enzo Porrello and A/Prof. David Elliott at MCRI, where she continues to study the molecular mechanisms of human cardiomyopathies in human stem cells.
Antonia (Toni) is a Research Officer at the Heart Regeneration and Disease group at the Murdoch Children’s Research Institute, which is part of the recently established Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW), Melbourne Node.
Antonia (Toni) is a Research Officer at the Heart Regeneration and Disease group at the Murdoch Children’s Research Institute, which is part of the recently established Novo Nordisk Foundation Centre for Stem Cell Medicine (reNEW), Melbourne Node.

After completing her masters in Molecular Life Sciences at the University of Hamburg, Germany, Antonia started her PhD in the lab of Prof. Lucie Carrier at the University Medical Center Hamburg-Eppendorf, Germany, where she investigated the autophagy-lysosomal pathway in human inherited cardiomyopathies. During her PhD, Antonia developed a strong affinity for stem cell research using human induced pluripotent stem cell-derived cardiomyocytes as a model of disease to evaluate disease pathomechanism of cardiomyopathies. After receiving her PhD in 2020, Antonia was awarded with a postdoc grant from the Research Promotion Fund of the Faculty of Medicine, University Medical Center Hamburg-Eppendorf, Germany, to finalize her projects. In 2022, she joined the lab of Prof. Enzo Porrello and A/Prof. David Elliott at MCRI, where she continues to study the molecular mechanisms of human cardiomyopathies in human stem cells.

Top Publications

  • Barz, MJ, Behrmann, L, Capron, D, Zuchtriegel, G, Steffen, FD, Kunz, L, Zhang, Y, Vermeerbergen, IJ, Marovca, B, Kirschmann, M, et al. B- and T-cell acute lymphoblastic leukemias evade chemotherapy at distinct sites in the bone marrow. Haematologica 108(5) : 1244 -1258 2024
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  • Zech, ATL, Prondzynski, M, Singh, SR, Pietsch, N, Orthey, E, Alizoti, E, Busch, J, Madsen, A, Behrens, CS, Meyer-Jens, M, et al. ACTN2 Mutant Causes Proteopathy in Human iPSC-Derived Cardiomyocytes. Cells 11(17) : 2745 2024
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  • Zech, ATL, Prondzynski, M, Singh, SR, Orthey, E, Alizoti, E, Busch, J, Madsen, A, Behrens, CS, Mearini, G, Lemoine, MD, et al. ACTN2 mutant causes proteopathy in human iPSC-derived cardiomyocytes. 2024
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  • Horváth, A, Christ, T, Koivumäki, JT, Prondzynski, M, Zech, ATL, Spohn, M, Saleem, U, Mannhardt, I, Ulmer, B, Girdauskas, E, et al. Case Report on: Very Early Afterdepolarizations in HiPSC-Cardiomyocytes—An Artifact by Big Conductance Calcium Activated Potassium Current (Ibk,Ca). Cells 9(1) : 253 2024
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  • McNamara, JW, Parker, BL, Voges, HK, Mehdiabadi, NR, Bolk, F, Ahmad, F, Chung, JD, Charitakis, N, Molendijk, J, Zech, ATL, et al. Alpha kinase 3 signaling at the M-band maintains sarcomere integrity and proteostasis in striated muscle. Nature Cardiovascular Research 2(2) : 159 -173 2023
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