photo of Elizabeth Ng

Elizabeth Ng

Elizabeth Ng

Details

Role Team Leader / Senior Research Officer
Research area Stem cell biology

Contact

Available for student supervision
Dr Elizabeth Ng is a Team Leader in the Blood Development Laboratory at the Murdoch Children's Research Institute (MCRI). After completing her undergraduate degree at the University of Melbourne, she received her PhD from Monash University in 2013. A major focus of her work is to generate transplantable haematopoietic stem cells (HSCs) from human pluripotent stem cells for tissue repair and regeneration, disease modeling and the testing of pharmaceuticals and other therapeutic products. Dr Ng has devised and patented protocols for haematopoietic differentiation together with a differentiation medium that supports the efficient production of large numbers of blood cells. APEL medium has been licensed and commercialised by STEMCELL Technologies. She has maintained a long-standing collaboration with Professor Andrew Elefanty (Blood Development) and Professor Ed Stanley (Immune Development), together making important contributions to the development of human pluripotent stem cell as a powerful experimental platform to drive advancement in differentiation systems, cell culture medium formulation and the use of genetic modifications of human pluripotent stem cell lines.

Her work has identified that the expression of the HOXA genes during differentiation is crucial for generating haematopoietic cells with a transcriptional profile similar to the 'preHSCs' seen in the aorta-gonad mesonephros (AGM) region of the human embryo. Her current work focuses upon the challenge of maturing these cells further to produce engraftable HSCs and to develop in vitro 'niches' that mimic the bone marrow in order to sustain them. Her work is supported by grants from the NHMRC, a research collaboration with CSL Ltd and she is currently a Principal Investigator of the Novo Nordisk Foundation Center for Stem Cell Medicine.

Dr Ng holds active collaborations with:
• Prof Andrew Elefanty, Blood Development Laboratory, Murdoch Children's Research Institute
• Prof Ed Stanley, Immune Development Laboratory, Murdoch Children's Research Institute
• Prof Constanze Bonifer, Institute of Cancer and Genomic Sciences, University of Birmingham
• Prof Hanna Mikkola, Department of Molecular, Cell and Developmental Biology University of California
Dr Elizabeth Ng is a Team Leader in the Blood Development Laboratory at the Murdoch Children's Research Institute (MCRI). After completing her undergraduate degree at the University of Melbourne, she received her PhD from Monash University in 2013. A...
Dr Elizabeth Ng is a Team Leader in the Blood Development Laboratory at the Murdoch Children's Research Institute (MCRI). After completing her undergraduate degree at the University of Melbourne, she received her PhD from Monash University in 2013. A major focus of her work is to generate transplantable haematopoietic stem cells (HSCs) from human pluripotent stem cells for tissue repair and regeneration, disease modeling and the testing of pharmaceuticals and other therapeutic products. Dr Ng has devised and patented protocols for haematopoietic differentiation together with a differentiation medium that supports the efficient production of large numbers of blood cells. APEL medium has been licensed and commercialised by STEMCELL Technologies. She has maintained a long-standing collaboration with Professor Andrew Elefanty (Blood Development) and Professor Ed Stanley (Immune Development), together making important contributions to the development of human pluripotent stem cell as a powerful experimental platform to drive advancement in differentiation systems, cell culture medium formulation and the use of genetic modifications of human pluripotent stem cell lines.

Her work has identified that the expression of the HOXA genes during differentiation is crucial for generating haematopoietic cells with a transcriptional profile similar to the 'preHSCs' seen in the aorta-gonad mesonephros (AGM) region of the human embryo. Her current work focuses upon the challenge of maturing these cells further to produce engraftable HSCs and to develop in vitro 'niches' that mimic the bone marrow in order to sustain them. Her work is supported by grants from the NHMRC, a research collaboration with CSL Ltd and she is currently a Principal Investigator of the Novo Nordisk Foundation Center for Stem Cell Medicine.

Dr Ng holds active collaborations with:
• Prof Andrew Elefanty, Blood Development Laboratory, Murdoch Children's Research Institute
• Prof Ed Stanley, Immune Development Laboratory, Murdoch Children's Research Institute
• Prof Constanze Bonifer, Institute of Cancer and Genomic Sciences, University of Birmingham
• Prof Hanna Mikkola, Department of Molecular, Cell and Developmental Biology University of California

Top Publications

  • Sun, S, See, M, Nim, HT, Strumila, K, Ng, ES, Hidalgo, A, Ramialison, M, Sutton, P, Elefanty, AG, Sarkar, S, et al. Human pluripotent stem cell-derived macrophages host Mycobacterium abscessus infection. Stem Cell Reports 17(9) : 2156 -2166 2022
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  • Calvanese, V, Capellera-Garcia, S, Ma, F, Fares, I, Liebscher, S, Ng, ES, Ekstrand, S, Aguadé-Gorgorió, J, Vavilina, A, Lefaudeux, D, et al. Mapping human haematopoietic stem cells from haemogenic endothelium to birth. Nature 604(7906) : 534 -540 2022
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  • Schnoeder, TM, Schwarzer, A, Jayavelu, AK, Hsu, C-J, Kirkpatrick, J, Döhner, K, Perner, F, Eifert, T, Huber, N, Arreba-Tutusaus, P, et al. PLCG1 is required for AML1-ETO leukemia stem cell self-renewal.. Blood 139(7) : 1080 -1097 2022
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  • Bruveris, FF, Ng, ES, Stanley, EG, Elefanty, AG. VEGF, FGF2, and BMP4 regulate transitions of mesoderm to endothelium and blood cells in a human model of yolk sac hematopoiesis. Experimental Hematology 103: 30 -39.e2 2021
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  • Bruveris, F, Elefanty, A, Leitoguinho, AR, Motazedian, A, Ng, E, Sourris, K, Stanley, E, Vlahos, K. 3005 – GROUP F SOX GENES CONTROL HUMAN EMBRYONIC VASCULAR PATTERNING VIA NOTCH SIGNALING. Experimental Hematology 100: s45 2021
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