A/Prof Elizabeth Ng
A/Prof Elizabeth Ng
Details
Role
Group Leader / Principal Research Fellow
Research area
Stem Cell Medicine
Group
Blood Development
Contact
Available for student supervision
A/Prof Elizabeth Ng is a Group Leader in the Blood Development Laboratory at MCRI. She completed her undergraduate degree at the University of Melbourne and received her PhD from Monash University. Elizabeth’s research uses induced pluripotent stem cell (iPSC) technology to investigate haematopoietic stem cell (HSC) formation during human development and to translate that to the in vitro differentiation of iPSCs to blood lineages. A major focus of her work is the generation of transplantable haematopoietic stem cells (iHSCs) from human iPSCs for tissue repair and regeneration, disease modeling and the testing of pharmaceuticals and other therapeutic products. She has devised and patented protocols for haematopoietic differentiation together with a differentiation medium that supports the efficient production of large numbers of blood cells. APEL medium has been licensed and commercialised by STEMCELL Technologies.
Together with long term collaborators Prof Andrew Elefanty and Prof Ed Stanley, her work showed that expression of the HOXA genes during differentiation identified haematopoietic cells with a transcriptional profile similar to blood cells seen in the aorta-gonad-mesonephros (AGM) region of the human embryo. In 2024 she published the first systematic method for generating transplantable HSCs from human iPSCs (iHSCs) which can be clinically translated to provide a source of personalised CD34+ iHSCs. She aims to understand the mechanisms that underlie iHSC maturation and to develop in vitro bone marrow-like 'niches' to sustain them. Her work is supported by grants from the NHMRC and the MRFF, a licensing agreement with Retro Biosciences, Inc, and the Novo Nordisk Fondation Center for Stem Cell Medicine, with whom she is a Principal Investigator.
Dr Ng holds active collaborations with:
• Prof Andrew Elefanty, Blood Development Laboratory, Murdoch Children's Research Institute
• Prof Ed Stanley, Immune Development Laboratory, Murdoch Children's Research Institute
• Prof Constanze Bonifer, Institute of Cancer and Genomic Sciences, University of Birmingham
• Prof Hanna Mikkola, Department of Molecular, Cell and Developmental Biology University of California
Together with long term collaborators Prof Andrew Elefanty and Prof Ed Stanley, her work showed that expression of the HOXA genes during differentiation identified haematopoietic cells with a transcriptional profile similar to blood cells seen in the aorta-gonad-mesonephros (AGM) region of the human embryo. In 2024 she published the first systematic method for generating transplantable HSCs from human iPSCs (iHSCs) which can be clinically translated to provide a source of personalised CD34+ iHSCs. She aims to understand the mechanisms that underlie iHSC maturation and to develop in vitro bone marrow-like 'niches' to sustain them. Her work is supported by grants from the NHMRC and the MRFF, a licensing agreement with Retro Biosciences, Inc, and the Novo Nordisk Fondation Center for Stem Cell Medicine, with whom she is a Principal Investigator.
Dr Ng holds active collaborations with:
• Prof Andrew Elefanty, Blood Development Laboratory, Murdoch Children's Research Institute
• Prof Ed Stanley, Immune Development Laboratory, Murdoch Children's Research Institute
• Prof Constanze Bonifer, Institute of Cancer and Genomic Sciences, University of Birmingham
• Prof Hanna Mikkola, Department of Molecular, Cell and Developmental Biology University of California
A/Prof Elizabeth Ng is a Group Leader in the Blood Development Laboratory at MCRI. She completed her undergraduate degree at the University of Melbourne and received her PhD from Monash University. Elizabeth’s research uses induced pluripotent stem...
A/Prof Elizabeth Ng is a Group Leader in the Blood Development Laboratory at MCRI. She completed her undergraduate degree at the University of Melbourne and received her PhD from Monash University. Elizabeth’s research uses induced pluripotent stem cell (iPSC) technology to investigate haematopoietic stem cell (HSC) formation during human development and to translate that to the in vitro differentiation of iPSCs to blood lineages. A major focus of her work is the generation of transplantable haematopoietic stem cells (iHSCs) from human iPSCs for tissue repair and regeneration, disease modeling and the testing of pharmaceuticals and other therapeutic products. She has devised and patented protocols for haematopoietic differentiation together with a differentiation medium that supports the efficient production of large numbers of blood cells. APEL medium has been licensed and commercialised by STEMCELL Technologies.
Together with long term collaborators Prof Andrew Elefanty and Prof Ed Stanley, her work showed that expression of the HOXA genes during differentiation identified haematopoietic cells with a transcriptional profile similar to blood cells seen in the aorta-gonad-mesonephros (AGM) region of the human embryo. In 2024 she published the first systematic method for generating transplantable HSCs from human iPSCs (iHSCs) which can be clinically translated to provide a source of personalised CD34+ iHSCs. She aims to understand the mechanisms that underlie iHSC maturation and to develop in vitro bone marrow-like 'niches' to sustain them. Her work is supported by grants from the NHMRC and the MRFF, a licensing agreement with Retro Biosciences, Inc, and the Novo Nordisk Fondation Center for Stem Cell Medicine, with whom she is a Principal Investigator.
Dr Ng holds active collaborations with:
• Prof Andrew Elefanty, Blood Development Laboratory, Murdoch Children's Research Institute
• Prof Ed Stanley, Immune Development Laboratory, Murdoch Children's Research Institute
• Prof Constanze Bonifer, Institute of Cancer and Genomic Sciences, University of Birmingham
• Prof Hanna Mikkola, Department of Molecular, Cell and Developmental Biology University of California
Together with long term collaborators Prof Andrew Elefanty and Prof Ed Stanley, her work showed that expression of the HOXA genes during differentiation identified haematopoietic cells with a transcriptional profile similar to blood cells seen in the aorta-gonad-mesonephros (AGM) region of the human embryo. In 2024 she published the first systematic method for generating transplantable HSCs from human iPSCs (iHSCs) which can be clinically translated to provide a source of personalised CD34+ iHSCs. She aims to understand the mechanisms that underlie iHSC maturation and to develop in vitro bone marrow-like 'niches' to sustain them. Her work is supported by grants from the NHMRC and the MRFF, a licensing agreement with Retro Biosciences, Inc, and the Novo Nordisk Fondation Center for Stem Cell Medicine, with whom she is a Principal Investigator.
Dr Ng holds active collaborations with:
• Prof Andrew Elefanty, Blood Development Laboratory, Murdoch Children's Research Institute
• Prof Ed Stanley, Immune Development Laboratory, Murdoch Children's Research Institute
• Prof Constanze Bonifer, Institute of Cancer and Genomic Sciences, University of Birmingham
• Prof Hanna Mikkola, Department of Molecular, Cell and Developmental Biology University of California
Top Publications
- Lewis, AC, Gruber, E, Franich, R, Armstrong, J, Kelly, MJ, Opazo, CM, Low, YC, Flippe, L, Wijanarko, K, Rowe, CL, et al. Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia.. Cell 189(1) : 215 -232.e24 2026 view publication
- Turner, DL, Baric, H, Patatsos, K, Amoozadeh, S, See, M, Strumila, KA, Murphy, JT, Gubbels, L, Ng, E, Elefanty, A, et al. Macrophages Mediate Antiviral Immunity and Repair of Type 2 Alveolar Epithelial Cells in a Human Stem Cell Model. 2026 view publication
- Maytum, A, Saxena, R, Sarila, G, Edirisinghe, H, Terolli, K, Bonifer, C, Stanley, E, Elefanty, A, Ng, E. 3012 – VASCULAR ENDOTHELIAL GROWTH FACTOR SIGNALING BLOCKS THE DEVELOPMENT OF HUMAN HEMATOPOIETIC STEM CELLS FROM INDUCED PLURIPOTENT STEM CELLS. Experimental Hematology 151: 104952 2025 view publication
- Dettle, S, Sedzro, D, Ng, E, Elefanty, A, Slukvin, I. 3028 – GENERATION OF ENGRAFTABLE HEMATOPOIETIC STEM AND PROGENITOR CELLS FROM NONHUMAN PRIMATE INDUCED PLURIPOTENT STEM CELLS. Experimental Hematology 151: 104969 2025 view publication
- Wijanarko, K, Nigos, R, Liani, O, Motazedian, A, Sun, S, Ng, E, Elefanty, A, Stanley, E. 3219 – HSPC PRIMING FOR IN VITRO T-CELL DIFFERENTIATIONS. Experimental Hematology 151: 105160 2025 view publication
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