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Prof John Bateman

Prof John Bateman

Details

Role Esteemed Honorary Fellow
Research area Stem Cell Medicine

Contact

Available for student supervision
Formation of the human skeleton and proper bone, cartilage, joint and muscle function are determined by complex interactions between developmental signalling pathways. Genetic and acquired disorders affecting these tissues are common. The group’s research is aimed at understanding the molecular basis of these disorders to improve diagnosis and counselling, identify new therapeutic targets and test the effectiveness of new treatments to ultimately improve the quality of life for children with these debilitating conditions
Formation of the human skeleton and proper bone, cartilage, joint and muscle function are determined by complex interactions between developmental signalling pathways. Genetic and acquired disorders affecting these tissues are common. The group’s...
Formation of the human skeleton and proper bone, cartilage, joint and muscle function are determined by complex interactions between developmental signalling pathways. Genetic and acquired disorders affecting these tissues are common. The group’s research is aimed at understanding the molecular basis of these disorders to improve diagnosis and counselling, identify new therapeutic targets and test the effectiveness of new treatments to ultimately improve the quality of life for children with these debilitating conditions

Top Publications

  • Yammine, KM, Abularach, SM, Kim, S-Y, Bikovtseva, AA, Lilianty, J, Butty, VL, Schiavoni, RP, Bateman, JF, Lamandé, SR, Shoulders, MD. Chondrodysplasia-inducing COL2A1 p.Gly1170Ser causes an ER storage defect without associated unfolded protein response in a human cartilage model.. 2023
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  • Lamandé, SR, Ng, ES, Cameron, TL, Kung, LHW, Sampurno, L, Rowley, L, Lilianty, J, Patria, YN, Stenta, T, Hanssen, E, et al. Modeling human skeletal development using human pluripotent stem cells. Proceedings of the National Academy of Sciences of the United States of America 120(19) : e2211510120 2023
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  • Yeung, C-YC, Olesen, AT, Wilson, R, Lamandé, SR, Bateman, JF, Svensson, RB, Magnusson, SP, Kjaer, M. Proteome profiles of intramuscular connective tissue: influence of aging and physical training. Journal of Applied Physiology 134(5) : 1278 -1286 2023
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  • Yammine, KM, Mirda Abularach, S, Sampurno, L, Bateman, JF, Lamandé, SR, Shoulders, MD. Using CRISPR/Cas9 to generate a heterozygous COL2A1 p.R719C iPSC line (MCRIi019-A-6) model of human precocious osteoarthritis. Stem Cell Research 67: 103020 2023
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  • Blank, M, McGregor, NE, Rowley, L, Kung, LHW, Crimeen-Irwin, B, Poulton, IJ, Walker, EC, Gooi, JH, Lamandé, SR, Sims, NA, et al. The effect of carbamazepine on bone structure and strength in control and osteogenesis imperfecta (Col1a2 +/p.G610C ) mice.. J Cell Mol Med 26(14) : 4021 -4031 2022
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