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Prof John Bateman

Prof John Bateman

Details

Role Esteemed Honorary Fellow
Research area Stem cell biology

Contact

Available for student supervision
Formation of the human skeleton and proper bone, cartilage, joint and muscle function are determined by complex interactions between developmental signalling pathways. Genetic and acquired disorders affecting these tissues are common. The group’s research is aimed at understanding the molecular basis of these disorders to improve diagnosis and counselling, identify new therapeutic targets and test the effectiveness of new treatments to ultimately improve the quality of life for children with these debilitating conditions
Formation of the human skeleton and proper bone, cartilage, joint and muscle function are determined by complex interactions between developmental signalling pathways. Genetic and acquired disorders affecting these tissues are common. The group’s...
Formation of the human skeleton and proper bone, cartilage, joint and muscle function are determined by complex interactions between developmental signalling pathways. Genetic and acquired disorders affecting these tissues are common. The group’s research is aimed at understanding the molecular basis of these disorders to improve diagnosis and counselling, identify new therapeutic targets and test the effectiveness of new treatments to ultimately improve the quality of life for children with these debilitating conditions

Top Publications

  • Blank, M, McGregor, NE, Rowley, L, Kung, LHW, Crimeen‐Irwin, B, Poulton, IJ, Walker, EC, Gooi, JH, Lamandé, SR, Sims, NA, et al. The effect of carbamazepine on bone structure and strength in control and osteogenesis imperfecta (Col1a2 +/p.G610C) mice. Journal of Cellular and Molecular Medicine 26(14) : 4021 -4031 2022
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  • Bateman, JF, Shoulders, MD, Lamandé, SR. Collagen misfolding mutations: the contribution of the unfolded protein response to the molecular pathology.. Connective Tissue Research 63(3) : 210 -227 2022
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  • Blank, M, McGregor, NE, Rowley, L, Kung, LH, Crimeen-Irwin, B, Poulton, IJ, Walker, EC, Gooi, JH, Lamande, SR, Sims, NA, et al. The effect of carbamazepine on bone structure and strength in control and Osteogenesis Imperfecta (Col1a2 +/p.G610C) mice. 2022
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  • Lilianty, J, Bateman, JF, Lamandé, SR. Generation of a heterozygous COL2A1 (p.G1113C) hypochondrogenesis mutation iPSC line, MCRIi019-A-7, using CRISPR/Cas9 gene editing. Stem Cell Research 56: 102515 2021
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  • DiChiara, AS, Doan, N-D, Bikovtseva, AA, Rowley, L, Butty, VL, Weis, ME, Eyre, DR, Lamandé, SR, Bateman, JF, Shoulders, MD. XBP1s-Mediated Endoplasmic Reticulum Proteostasis Network Enhancement Can Selectively Improve Folding and Secretion of an Osteogenesis Imperfecta-Causing Collagen-I Variant. 2021
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