photo of Dr Kothila Tharmarajah

Dr Kothila Tharmarajah

Dr Kothila Tharmarajah

Details

Role Research Officer
Research area Stem Cell Medicine

Contact

Dr Kothila Tharmarajah is a Research Officer in the Immune Development laboratory at the Murdoch Children's Research Institute. Her research focuses on using induced pluripotent stem cells to develop a 'humanised' animal model and subsequently evaluate the B lymphocyte development and antibody response within this model. Her research interests include immunology in the context of viral infections, autoimmune diseases and B cell lymphomas.

Kothila completed her Bachelor of Biomedicine at The University of Melbourne in 2012 and then undertook an honours project elucidating the role of B cells in atherosclerosis at the Baker IDI Heart and Diabetes Institute (Monash University) in 2013. Kothila was awarded the Griffith University Postgraduate Research Scholarship and completed her PhD, studying the role of viral envelope glycan on skin immune responses in arboviral infection, at the Menzies Health Institute Queensland under the supervision of Dr. Ali Zaid and Dr. Adam Taylor, in 2022.
Dr Kothila Tharmarajah is a Research Officer in the Immune Development laboratory at the Murdoch Children's Research Institute. Her research focuses on using induced pluripotent stem cells to develop a 'humanised' animal model and subsequently...
Dr Kothila Tharmarajah is a Research Officer in the Immune Development laboratory at the Murdoch Children's Research Institute. Her research focuses on using induced pluripotent stem cells to develop a 'humanised' animal model and subsequently evaluate the B lymphocyte development and antibody response within this model. Her research interests include immunology in the context of viral infections, autoimmune diseases and B cell lymphomas.

Kothila completed her Bachelor of Biomedicine at The University of Melbourne in 2012 and then undertook an honours project elucidating the role of B cells in atherosclerosis at the Baker IDI Heart and Diabetes Institute (Monash University) in 2013. Kothila was awarded the Griffith University Postgraduate Research Scholarship and completed her PhD, studying the role of viral envelope glycan on skin immune responses in arboviral infection, at the Menzies Health Institute Queensland under the supervision of Dr. Ali Zaid and Dr. Adam Taylor, in 2022.

Top Publications

  • Tharmarajah, K, Everest-Dass, A, Vider, J, Liu, X, Freitas, JR, Mostafavi, H, Bettadapura, J, von Itzstein, M, West, NP, Taylor, A, et al. N-Linked Glycans Shape Skin Immune Responses during Arthritis and Myositis after Intradermal Infection with Ross River Virus. Journal of Virology 96(17) : e00999 -e00922 2022
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  • PLOS Pathogens Staff. Correction: Interleukin-17 contributes to Ross River virus-induced arthritis and myositis.. PLoS Pathog 18(4) : e1010519 2022
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  • Zaid, A, Tharmarajah, K, Mostafavi, H, Freitas, JR, Sheng, K-C, Foo, S-S, Chen, W, Vider, J, Liu, X, West, NP, et al. Modulation of Monocyte-Driven Myositis in Alphavirus Infection Reveals a Role for CX3CR1+ Macrophages in Tissue Repair. mBio 11(2) : e03353 -e03319 2020
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  • Abeyratne, E, Tharmarajah, K, Freitas, JR, Mostafavi, H, Mahalingam, S, Zaid, A, Zaman, M, Taylor, A. Liposomal Delivery of the RNA Genome of a Live-Attenuated Chikungunya Virus Vaccine Candidate Provides Local, but Not Systemic Protection After One Dose.. Front Immunol 11: 304 2020
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  • Chen, W, Foo, S-S, Zaid, A, Teng, T-S, Herrero, LJ, Wolf, S, Tharmarajah, K, Vu, LD, van Vreden, C, Taylor, A, et al. Specific inhibition of NLRP3 in chikungunya disease reveals a role for inflammasomes in alphavirus-induced inflammation. Nature Microbiology 2(10) : 1435 -1445 2017
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Career information