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Dr Lea Flippe

Dr Lea Flippe

Details

Role Research Officer
Research area Stem Cell Medicine

Contact

Dr Léa Flippe is a Research Officer in the Blood Development group led by Professor Andrew Elefanty at the Murdoch Children's Research Institute. She is currently working with Dr Elizabeth Ng on differentiating haematopoietic stem cells (HSCs) from human induced pluripotent stem cells and the development of an assay to predict the engraftment outcome of these in vitro generated human HSCs in mice.

Léa’s passion for pluripotent stem cells led her to complete her PhD at University of Nantes under the supervision of Dr. Laurent David and Dr. Carolle Guillonneau. In this time, Léa’s research was focused on understanding the mechanisms of differentiation to efficiently generate haematopoietic stem cells, T cells and regulatory T cells from human induced pluripotent stem cells. As a Stem Cell Biologist, Léa has gained a large skill set and knowledge base in the field of in vitro culture and manipulation of human pluripotent stem cells and haematopoietic differentiation.
Dr Léa Flippe is a Research Officer in the Blood Development group led by Professor Andrew Elefanty at the Murdoch Children's Research Institute. She is currently working with Dr Elizabeth Ng on differentiating haematopoietic stem cells (HSCs) from...
Dr Léa Flippe is a Research Officer in the Blood Development group led by Professor Andrew Elefanty at the Murdoch Children's Research Institute. She is currently working with Dr Elizabeth Ng on differentiating haematopoietic stem cells (HSCs) from human induced pluripotent stem cells and the development of an assay to predict the engraftment outcome of these in vitro generated human HSCs in mice.

Léa’s passion for pluripotent stem cells led her to complete her PhD at University of Nantes under the supervision of Dr. Laurent David and Dr. Carolle Guillonneau. In this time, Léa’s research was focused on understanding the mechanisms of differentiation to efficiently generate haematopoietic stem cells, T cells and regulatory T cells from human induced pluripotent stem cells. As a Stem Cell Biologist, Léa has gained a large skill set and knowledge base in the field of in vitro culture and manipulation of human pluripotent stem cells and haematopoietic differentiation.

Top Publications

  • Flippe, L, Gaignerie, A, Sérazin, C, Baron, O, Saulquin, X, Anegon, I, David, L, Guillonneau, C. Generation of CD34+CD43+ Hematopoietic Progenitors to Induce Thymocytes from Human Pluripotent Stem Cells.. Cells 11(24) : 2022
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  • Benallegue, N, Nicol, B, Lasselin, J, Bézie, S, Flippe, L, Regue, H, Vimond, N, Remy, S, Garcia, A, Le Frère, F, et al. Patients With Severe Multiple Sclerosis Exhibit Functionally Altered CD8+ Regulatory T Cells.. Neurol Neuroimmunol Neuroinflamm 9(6) : 2022
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  • Besnard, M, Sérazin, C, Ossart, J, Moreau, A, Vimond, N, Flippe, L, Sein, H, Smith, GA, Pittaluga, S, Ferré, EMN, et al. Anti-CD45RC antibody immunotherapy prevents and treats experimental Autoimmune PolyEndocrinopathy Candidiasis Ectodermal Dystrophy syndrome. Journal of Clinical Investigation 132(7) : e156507 2022
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  • Castel, G, Meistermann, D, Bretin, B, Firmin, J, Blin, J, Loubersac, S, Bruneau, A, Chevolleau, S, Kilens, S, Chariau, C, et al. Induction of Human Trophoblast Stem Cells from Somatic Cells and Pluripotent Stem Cells. Cell Reports 33(8) : 108419 2020
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  • Flippe, L, Gaignerie, A, Sérazin, C, Baron, O, Saulquin, X, Themeli, M, Guillonneau, C, David, L. Rapid and Reproducible Differentiation of Hematopoietic and T Cell Progenitors From Pluripotent Stem Cells.. Front Cell Dev Biol 8: 577464 2020
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