You are here
Dr Adam Piers
Adam Piers is the coordinator of CardioRegen at the Melbourne Children's Campus. Adam has been at the Murdoch Children's Research Institute since 2012, where he undertook a PhD under the supervision of A/Professor Shireen Lamande investigating preclinical therapies for Duchenne Muscular Dystrophy. Following completion of his PhD in 2016, Adam has worked within the Heart Research team initially as a Clinical Research Coordinator, and now as coordinator of CardioRegen.
The Melbourne Centre for Cardiovascular Genomics and Regenerative Medicine (CardioRegen) brings together clinicians and researchers across the Melbourne Children's Campus and Parkville Precinct to transform the clinical care of patients with childhood heart disease.
CardioRegen will embed a framework for discovery through to translation encompassing three major research programs in 1 - Diagnostics, 2 - Discovery and 3 – Translation. Collectively, these programs will establish key resources and technology platforms that will feed into a broader research program across the cardiovascular space including the establishment of a large biobank including cardiac tissues, DNA and patient-matched stem cells for disease modeling and development of new personalised regenerative medicine approaches.
Houweling PJ, Coles CA, Tiong CF, Nielsen B, Graham A, McDonald P, Suter A, Piers AT, Forbes R, Ryan MM, Howden SE, Lamandé SR, North KN (2021). Generating an iPSC line (with isogenic control) from the PBMCs of an ACTA1 (p.Gly148Asp) nemaline myopathy patient. Stem Cell Res. 54:102429.
Sim CB, Phipson B, Ziemann M, Rafehi H, Mills RJ, Watt KI, Abu-Bonsrah KD, Kalathur RKR, Voges HK, Dinh DT, Ter Huurne M, Vivien CJ, Kaspi A, Kaipananickal H, Hidalgo A, Delbridge LMD, Robker RL, Gregorevic P, Dos Remedios CG, Lal S, Piers AT, Konstantinov IE, Elliott DA, El-Osta A, Oshlack A, Hudson JE, Porrello ER (2021). Sex-Specific Control of Human Heart Maturation by the Progesterone Receptor. Circulation. 143:1614–1628.
Coles CA, Gordon L, Hunt LC, Webster T, Piers AT, Kintakas C, Woodman K, Touslon SL, Smythe GM, White JD, Lamandé SR. Expression profiling in exercised mdx suggests a role for extracellular proteins in the dystrophic muscle immune response (2020). Hum Mol Genet. 29(3):353-368.
Borovikov YS, Rysev NA, Karpicheva OE, Sirenko VV, Avrova SV, Piers A, Redwood CS (2017). Molecular mechanisms of dysfunction of muscle fibres associated with Glu139 deletion in TPM2 gene. Sci Rep. 7(1):16797
Borovikov YS, Simonyan AO, Karpicheva OE, Avrova SV, Rysev NA, Sirenko VV, Piers A, Redwood CS (2017). The reason for a high Ca2+-sensitivity associated with Arg91Gly substitution in TPM2 gene is the abnormal behavior and high flexibility of tropomyosin during the ATPase cycle. Biochem Biophys Res Commun. 494(3-4):681-686.
Borovikov YS, Avrova SV, Rysev NA, Sirenko VV, Simonyan AO, Chernev AA, Karpicheva OE, Piers A, Redwood CS (2015). Aberrant movement of β-tropomyosin associated with congenital myopathies causes defective response of myosin heads and actin during the ATPase cycle. Archives of Biochemistry and Biophysics. 577: 11-23.
Karpicheva OE, Robinson P, Piers A, Borovikov YS, Redwood CS (2013). The Nemaline myopathy-causing E117 mutation in β-tropomyosin reduces thin filament activation. Archives of Biochemistry and Biophysics. 536 (1): 25-30.
Piers AT, Lavin T, Radley-Crabb HG, Bakker AJ, Grounds MD, Pinniger GJ (2011). Blockade of TNF in vivo using cV1q antibody reduces contractile dysfunction of skeletal muscle in response to eccentric exercise in dystrophic mdx and normal mice. Neuromuscular Disorders. 21:132–141.
The Royal Children's Hospital Foundation