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A/Professor David Elliott
Dr David Elliott completed his PhD at the Victor Chang Cardiac Research Institute, performing a structure/function analysis of Nkx2-5, a key regulator of cardiogenesis. He identified and characterised a novel, evolutionarily conserved tyrosine rich transactivation domain.
For his postdoctorate Dr Elliott worked at The Gurdon Institute at Cambridge University investigating the role of an E3 ubiquitin ligase, the anaphase-promoting complex, in neural cell function and fate in Drosophila.
In 2007 he joined the Monash Immunology and Stem Cell Laboratories with Professor Andrew Elefanty and Ed Stanley working on the generation of purified populations of human heart cells from the in vitro differentiation of human embryonic stem cells (hESCs). In late 2012 he established the Cardiac Development Laboratory at Murdoch Childrens Research Institute continuing to work on differentiating hESCs as a model of human heart development.
Dr David Elliot's research focuses on the use of pluripotent stem cells – those generated from adult cells – to study human heart development and disease. The goal is to improve the understanding of the differentiation of human embryonic stem cells into cardiac progenitors and onto mature cardiomyocytes. In particular, his team is interested in identifying cell surface markers of cardiovascular lineages and defining the genetic networks that regulate human cardiogenesis.
- Generation of a cell lineage fate map of human heart development.
- The role of micro-RNAs in human cardiac specification and disease.