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A/Professor Deanne Thompson
Dr Thompson is a Senior Neuroscientist leading a Neuroimaging team focused on outcomes following preterm birth. She coordinates the critical Magnetic Resonance Imaging (MRI) analysis component of nine projects including two multi-centre randomised controlled trials, and an intervention trial. Her team consists of five research assistants and seven PhD students, with a further three PhD and four honours completions in the past three years.
She holds a National Health and Medical Research Council (NHMRC) Career Development Fellowship and is a Chief Investigator on 4 NHMRC project grants, and the NHMRC Centre for Research Excellence in Newborn Medicine, with funding totaling $6.6m since 2011.
Dr Thompson consistently publishes in the top general neuroscience journals (Brain, Annals of Neurology, Cortex), and the top two in her fields of neuroimaging and paediatrics (NeuroImage, Human Brain Mapping, Pediatrics). She regularly presents at leading national and international conferences, such as the International Society of Magnetic Resonance in Medicine and Pediatric Academic Society.
- Honorary Research Associate, Department of Paediatrics, University of Melbourne
- Honorary Research Associate, Florey Institute of Neuroscience and Mental Health
- 2014: NHMRC Career Development Fellowship
- 2014: Early Career Researcher 'Discovery Award' for excellence in research, Murdoch Childrens Research Institute
- 2014: Victorian Young Tall Poppy Award for excellence in science, Australian Institute of Policy and Science
- 2013: Theo Murphy High Flyers Think Tank, 'Inspiring smarter brain research in Australia' participant and Rapporteur, Australian Academy of Science. Produced a recommendations document on future policy for Brain research in Australia, launched to Australian Government at Parliament House
- 2012: 'Fresh Science' Victorian state finalist, Science In Public
- 2011: NHMRC Early Career Fellowship
- 2007, 2009, 2011: Student/Post-doctoral Travel Award, International Society for Magnetic Resonance in Medicine
- 2008: Student Travel Award, Australian Neuroscience Society
- 2007: Australian Postgraduate Award, University of Melbourne
Dr Thompson applies state-of-the-art MRI techniques to better understand how brain abnormalities in preterm infants relate to their functional impairments. Preterm children are at risk of intellectual, social-emotional, behavioural, sensory and movement disorders. These impairments are likely to be related to brain abnormalities, as preterm infants are born at a time when their brain is vulnerable to injury and developing at an unparalleled rate.
Dr Thompson has expertise in a range of advanced MRI analyses techniques that enable analysis of brain structure (volumetrics, spherical harmonic shape analysis, cortical morphometry), white matter microstructure (diffusion tensor imaging and advanced diffusion modelling, constrained spherical deconvolution, tractography), and brain connectivity (graph theory). Using MRI, Dr Thompson's research aims to (1) diagnose infants at high-risk of neurological dysfunction, (2) improve understanding of preterm infant brain development and the trajectory of brain injury and throughout childhood, and (3) assess the effectiveness of new treatments and interventions designed to improve long-term neurodevelopment in infants at risk.
Dr Thompson's long-term vision is to enhance quality of life and improve outcomes for infants who experience an unfavourable start to life because of abnormal brain development or injury.
- Late Preterm Study ( LaPrem): The Burden of Late Preterm Birth on Brain Development and 2 Year Outcomes: A Prospective, Longitudinal Cohort Study
- Victorian Infant Brain Studies 2nd Cohort (VIBeS 2): Neurobehaviour Between Birth and 40 Weeks In Infants Born <30 Weeks' Gestation: Predictors of Brain Development and Later Neurodevelopmental Outcome
- Improving Memory in Preterm Randomised Intervention Trial (IMPRINT): Preventing Academic Difficulties in Preterm Children: An Adaptive Working Memory Training Intervention
- Victorian Infant Brain Studies 13 year old follow-up (VIBeS 13): Executive dysfunction and brain development in very preterm children
- Australian Temperament Project (ATP): The role of maternal history of mental disorder in fetal brain development and infant emotional regulation
Thompson, D.K.; Lee, K.J.; Egan, G.F.; Warfield, S.K.; Doyle, L.W.; Anderson, P.J.; Inder, T.E. Regional white matter microstructure in very preterm infants: Predictors and 7 year outcomes. Cortex (2014) 52: 60-74
Thompson, D.K.; Omizzolo, C.; Adamson, C.; Lee, K.J.; Stargatt, R.; Egan, G.F.; Doyle, L.W.; Inder, T.E.; Anderson, P.J. Longitudinal growth and morphology of the hippocampus through childhood: Impact of prematurity and implications for memory and learning. Human Brain Mapping (2014) 35 (8): 4129–4139
Thompson, D. K.; Adamson, C.; Roberts, G.; Faggian, N.; Wood, S. J.; Warfield, S. K.; Doyle, L. W.; Anderson, P. J.; Egan, G. F.; Inder, T. E. Hippocampal shape variations at term equivalent age in very preterm infants compared with term controls: Perinatal predictors and functional significance at age 7 Neuroimage (2013) 70: 278-287
Thompson, D. K.; Thai, D.; Kelly, C. E.; Leemans, A.; Tournier, J. D.; Kean, M. J.; Lee, K. J.; Inder, T. E.; Doyle, L. W.; Anderson, P. J.; Hunt, R. W. Alterations in the optic radiations of very preterm children-Perinatal predictors and relationships with visual outcomes Neuroimage Clin (2013) 4: 145-53
Thompson, D. K.; Ahmadzai, Z. M.; Wood, S. J.; Inder, T. E.; Warfield, S. K.; Doyle, L. W.; Egan, G. F. Optimizing hippocampal segmentation in infants utilizing MRI post-acquisition processing Neuroinformatics (2012) 10 (2): 173-80
Thompson, D. K.; Inder, T. E.; Faggian, N.; Warfield, S. K.; Anderson, P. J.; Doyle, L. W.; Egan, G. F. Corpus callosum alterations in very preterm infants: perinatal correlates and 2 year neurodevelopmental outcomes Neuroimage (2012) 59 (4): 3571-81
Thompson, D. K.; Inder, T. E.; Faggian, N.; Johnston, L.; Warfield, S. K.; Anderson, P. J.; Doyle, L. W.; Egan, G. F. Characterization of the corpus callosum in very preterm and full-term infants utilizing MRI Neuroimage (2011) 55 (2): 479-90
Thompson, D. K.; Wood, S. J.; Doyle, L. W.; Warfield, S. K.; Egan, G. F.; Inder, T. E. MR-determined hippocampal asymmetry in full-term and preterm neonates Hippocampus (2009) 19 (2): 118-23
Thompson, D. K.; Wood, S. J.; Doyle, L. W.; Warfield, S. K.; Lodygensky, G. A.; Anderson, P. J.; Egan, G. F.; Inder, T. E. Neonate hippocampal volumes: prematurity, perinatal predictors, and 2-year outcome Ann Neurol (2008) 63 (5): 642-51
Thompson, D. K.; Warfield, S. K.; Carlin, J. B.; Pavlovic, M.; Wang, H. X.; Bear, M.; Kean, M. J.; Doyle, L. W.; Egan, G. F.; Inder, T. E. Perinatal risk factors altering regional brain structure in the preterm infant Brain (2007) 130 (3): 667-77