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Dr Penelope Bryant
Dr Penelope Bryant is a paediatric infectious disease physician and general paediatrician who has trained and worked in the UK and Australia. She completed her PhD in infectious diseases at the University of Melbourne and is the clinical research coordinator of the Department of General Medicine as well as group co-leader of the Murdoch Childrens Clinical Paediatrics group since its inception. In addition to a clinical appointment in the Infectious Diseases Unit at the Royal Children's Hospital, Dr Bryant is the medical lead of Hospital-in-the-Home (HITH). She has overseen the clinical expansion of the service and directs its research. She is the paediatric lead of the Australasian HITH Society. She is chair of the Antimicrobial Stewardship (AMS) Committee at RCH and also of ANZPID-ASAP, the Australasian paediatric AMS group, and a member of GARPEC, the global AMS in children group.
- Paediatric Infectious Diseases Physician and General Paediatrician, the Royal Children's Hospital
- Medical lead of Hospital-in-the-Home, RCH @ Home
- Clinical Research Coordinator, General Medicine, the Royal Children's Hospital
- Australasian HITH Society Conference Best Poster Award, 2013
- University of Melbourne PhD Chancellor's Prize Nomination, 2009
Dr Penelope Bryant's research interests are in infectious diseases and antimicrobial stewardship (AMS) clinical research, and health services research, especially in Hospital-in-the-Home (HITH).
Her infectious diseases research has had a broad base both in the laboratory (her PhD involved microarrays and gene expression) and clinical research. Her current interests are in infections in patients whose immune systems are compromised, specifically HIV in a low prevalence population and the use of antibiotics in haematology/oncology. Her research in AMS has involved leading multicentre studies across Australasia in antimicrobial prescribing and defining resources available for AMS in children, which are woeful.
Her research in HITH is both in optimising antimicrobial prescribing in the home setting, and trying to find innovative ways to improve care for children being treated at home with hospital interventions including telemedicine.
- CHOICE study (Cellulitis: Home Or Inpatient in Children from Emergency)
- Increasing the use of Hospital-in-the-Home for children referred directly from the Emergency Department
- The feasibility and acceptability of physiotherapy by telemedicine for children in Hospital-in-the-home
- The relationship between the opinions of physicians caring for children with haematological malignancies and their prescribing of antibiotics
- Antimicrobial stewardship resources, activities and guidelines
Bryant PA, Noronha J. Raging bull neck. New Eng J Med. In press. (IF 54.4)
Osowicki J, Gwee A, Noronha J, Palasanthiran P, McMullan B, Britton PN, Isaacs D, Lai T, Nourse C, Avent M, Moriarty P, Clark J, Francis JR, Blyth CC, Cooper CM, Bryant PA, on behalf of the ANZPID-ASAP group. The Impact of an Infectious Diseases Consultation on Antimicrobial Prescribing. Pediatr Inf Dis J June 2014; 33(6):669-71. (IF 3.6)
Kieu V, Palit S, Wilson G, Ditchfield M, Buttery J, Burgner D, Bryant PA. Cervical Spondylodiscitis Following Button Battery Ingestion. J Pediatr. Mar 2014. pii: S0022-3476(14): 00133-4. (IF 4.0)
Bryant PA, Smyth GK, Gooding T, Oshlack A, Harrington Z, Currie B, Carapetis JR, Robins-Browne R, Curtis N. Susceptibility to acute rheumatic fever based on differential expression of genes involved in cytotoxicity, chemotaxis, and apoptosis. Infect Immun. 2014 Feb;82(2):753-61. (IF 4.1)
Felsenstein S, Williams B, Shingadia D, Coxon L, Riordan A, Demetriades AK, Chandler CL, Bassi S, Koutoumanou, Stapleton S, Sharland M, Bryant PA. Clinical and microbiological features guiding treatment recommendations for brain abscesses in children. Ped Inf Dis J Feb 2013; 32(2):129-35. (IF 3.6)
Gwee A, Chinnappan M, Connell TG, Clarnette T, Bryant PA. The water lily sign. J Pediatrics Dec 2012: http://dx.doi.org/10.1016/j.jpeds.2012.12.068. (IF 4.4)
Bryant PA, Smyth GK, Robins-Browne R, Curtis N. Technical variability is greater than biological variability in a microarray experiment but both are outweighed by changes induced by stimulation. PLoS One 2011;6(5):e19556. (IF 4.4, Cited by 5)
Bryant PA, Tebruegge M, Papadakis G, Clarke C, Barnett P, Daley A, South M, Curtis N. Clinical and microbiologic features associated with novel swine-origin influenza A pandemic 2009 (H1N1) virus in children: a prospective cohort study. Ped Inf Dis J Aug 2010; 29(8):694-8. (IF 3.6, Cited by 15)
Bryant PA, Smyth GK, Robins-Browne R, Curtis N. Detection of gene expression in an individual cell type within a cell mixture using microarray analysis. PLoS ONE Feb 2009; 4(2): e4427. (IF 4.4, Cited by 10)
Bryant PA, Robins-Browne R, Carapetis JR, Curtis N. Some of the people, some of the time: susceptibility to acute rheumatic fever. Circulation Feb 2009; 119(5): 742-753. (IF 15.2, Cited by 49)