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A/Professor Enzo Porrello
Dr Enzo Porrello heads the Cardiac Regeneration Laboratory at the Murdoch Childrens Research Institute, The Royal Children's Hospital, Melbourne, and is a Senior Research Fellow in the School of Biomedical Sciences at The University of Melbourne.
After completing his PhD in Physiology at The University of Melbourne, Dr Porrello was awarded an NHMRC/NHF C.J. Martin Fellowship to undertake postdoctoral training in Prof Eric Olson's laboratory at UT Southwestern Medical Center in Dallas, USA. Upon returning to Australia in 2012, Dr Porrello established the Cardiac Regeneration Laboratory at The University of Queensland, which he co-headed together with Dr James Hudson from 2013-2017. Dr Porrello maintains strong links to The University of Queensland where he holds an honorary appointment as an Associate Professor in the School of Biomedical Sciences.
Dr Porrello has made a number of contributions to field of cardiac developmental and regenerative biology over the past 10 years. His discovery of a previously unappreciated developmental window for cardiac regeneration in the neonatal period has opened up an entirely new field of research, which has broad implications for the development of cardiac regenerative therapies for congenital and acquired forms of heart disease. His laboratory has contributed to an enhanced understanding of the transcriptional and epigenetic mechanisms governing cardiomyocyte maturation in the neonata period, which remains a major area of research focus in his group. Ongoing work harnesses a range of technologies including animal models and human cardiac organoids derived from patient stem cells for disease modeling and drug development.
Dr Porrello curerntly holds an NHMRC Career Development Fellowhsip and a Heart Foundation Future Leader Fellowship. His research has been recognised by a number of prestigious awards including the NHF Paul Korner Innovation Award, Heart Foundation Researcher of the Year (Qld), UQ Foundation for Research Excellence Award, A.K. McIntyre Prize (Australian Physiological Society) and the UT Southwestern Psotdoctoral Achievement Award.
Senior Research Fellow, Department of Physiology, The University of Melbourne
Honorary Associate Professor, School of Biomedical Sciences, The University of Queensland
2016 NHMRC/NHF Career Development Fellowship
2015 NHF Paul Korner Innovation Award
2015 Heart Foundation Qld Researcher of the Year
2015 Barbara Ell Lecture – Victor Chang Cardiac Research Institute
2014 UQ Foundation for Research Excellence Award
2013 A.K. McIntyre Medal (Australian Physiological Society)
2012 UT Southwestern Postdoctoral Research Achievement Award
2010 Dean's Award for Excellence in a PhD Thesis, University of Melbourne
2009 NHMRC/NHF CJ Martin Postdoctoral Fellowship
2006 Young Investigator Award (Angiotensin Gordon Conference)
2005 Young Investigator Prize (HBPRCA)
2005 Young Investigator Award (ISHR)
2004 Dean's Award (Honours Level), University of Melbourne
Our laboratory is interested in understanding the molecular mechanisms that guide heart development and regeneration. We have recently discovered that the newborn heart has a remarkable capacity to regenerate itself following injury, which is in stark contrast to the adult heart. Our mission is to decipher the fundamental differences between the regenerative newborn heart and the non-regenerative adult heart. Ultimately, we hope to discover novel drug targets for the replenishment of heart muscle cells in order to allow the diseased heart to repair itself and prevent heart failure.
Our laboratory uses a variety of approaches including molecular genetic studies in mice through to functional genomic studies using human patient stem cells.
Post-natal control of cardiac gene regulatory networks.
Epigenetic modifications are critical for the precise temporal regulation of gene expression during heart development. We are trying to map the changes in the genomic landscape during post-natal heart development to identify the molecular drivers of cardiac regeneration during early developmental stages.
Modelling human heart development using human cardiac organoids.
Recent advances in stem cell sciences and tissue engineering are providing unparalleled opportunities to generate human heart tissues in a dish. We are using human cardiac organoids to understand the mechanisms that regulate the developmental maturation of human heart muscle.
Functional genomic screens for cardiovascular drug discovery.
We are also applying unbiased screening approaches to identify novel therapeutic candidates for cardiac regeneration in human cardiac organoids.
- Quaife-Ryan GA, Sim CB, Ziemann, M, Kaspi A, Rafehi H, Ramialison M, El-Osta A, Hudson JE*, Porrello ER*. Multicellular transcriptional analysis of mammalian heart regeneration. Circulation. 2017. 136(12):1123-1139. *Co-corresponding.
- Mills RM et al. Elliott DA, Porrello ER*, Hudson JE*. Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest. Proc Natl Acad Sci USA. 2017. 114(40):E8372-E8381. *Co-corresponding.
- Voges HK, Mills RJ, Elliott DA, Parton RG, Porrello ER*, Hudson JE*. Development of a human cardiac organoid model reveals innate regenerative potential. Development. 2017. 144(6):1118-1127. *Co-corresponding.
- Sim CB, Ziemann M, Kaspi A, Harikrishnan KN, Ooi J, Khurana I, Chang L, Hudson JE, El-Osta A, Porrello E.R. Dynamic changes in the cardiac methylome during post-natal development. FASEB J. 2015. 29(4):1329-43.
- Aurora AB, Porrello ER, Tan W, Mahmoud AI, Hill JA, Bassel-Duby R, Sadek HA, Olson EN. Macrophages are required for neonatal heart regeneration. J Clin Invest. 2014. 124(3):1382-92.
- Xin M, Kim Y, Sutherland LB, Murakami M, Qi X, McAnally J, Porrello ER, Mahmoud AI, Tan W, Shelton JM, Richardson JA, Sadek HA, Bassel-Duby R, Olson EN. Hippo pathway effector Yap promotes cardiac regeneration. Proc Natl Acad Sci USA. 2013. 110(34): 13839-44.
- Mahmoud AI, Kocabas, F, Muralidhar S, Kimura W, Koura AS, Thet S, Porrello ER, Sadek HA. Meis1 regulates post-natal cardiomyocyte cell cycle arrest. Nature. 2013. 497(7448): 249-53.
- Porrello ER, Mahmoud AI, Simpson E, Johnson BA, Grinsfelder D, Canseco D, Mammen PP, Rothermel BA, Olson EN, Sadek HA. Regulation of neonatal and adult heart regeneration by the miR-15 family. Proc Natl Acad Sci USA. 2013. 110(1): 187-92.
- Porrello ER, Mahmoud AI, Simpson E, Hill JA Richardson JA, Olson EN, Sadek H. Transient regenerative potential of the neonatal mouse heart. Science. 2011. 331(6020): 1078-80.
- Porrello ER, Johnson BA, Aurora AB, Simpson E, Nam Y-J, Matkovich SJ, Dorn GW, van Rooij E, Olson EN. miR-15 family regulates postnatal mitotic arrest of cardiomyocytes. Circulation Research. 2011. 109(6): 670-9.
2018-2019 Australian Research Council Special Strategic Initiative
'Stem Cells Australia'
2016-2019 NHMRC CDF and Heart Foundation Future Leader Fellowship
'An RNA-based strategy for heart regeneration'
2016-2018 NHMRC Project Grant
'Targeted direct reprogramming of adult cardiac fibroblasts to functional cardiomyocytes'
2015-2017 NHMRC Project Grant
'Regulation of endogenous heart regeneration by an anti-fibrotic microRNA'
2015-2017 NHMRC Project Grant
'Regulation of heart development and regeneration by DNA methylation'