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Dr Jessica Vanslambrouck
Dr Jessica Vanslamrouck is currently a Postdoctoral Researcher Officer in the Kidney Development, Disease and Regeneration Group led by Professor Melissa Little (Murdoch Children's Research Institute, Melbourne). Her research career over the last 10 years has centered on kidney physiology, disease and regeneration, with a strong focus on understanding kidney disorders and novel regenerative therapies. Dr Vanslambrouck completed her Honors and PhD candidatures with the support of an Australian Postgraduate Award in the Gene and Stem Cell Therapy Program led by Professor John Rasko (Centenary Institute, Sydney). Here her research into the expression of renal amino acid transporters contributed to elucidating the complex mechanisms behind inherited and developmental disorders of amino acid uptake, as well as recognising a correlation between transporter expression and kidney transplant rejection. Following the completion of her PhD, Dr Vanslambrouck joined Professor Little's Kidney Research group (formerly in the Institute for Molecular Bioscience, Queensland), world-leaders in the fields of kidney development, kidney stem cells and renal regeneration. Her postdoctoral work has primarily involved the investigation of novel therapeutic options for chronic kidney disease through re-creation of the transient embryonic kidney stem cell (nephron progenitor) population present during development. This research has contributed to the first reports of direct reprogramming to nephron progenitors as well as a directed differentiation protocol that generates complex 'mini-kidney' organoids from pluripotent stem cells. More recently, Dr Vanslambrouck's focus on kidney organoids has expanded to include overall improvement of organoid development and maturation, as well as modifying this protocol to improve nephron progenitor maintenance.
- ISSCR International Travel Award, 2017
- Cell Reprogramming Australia Best Oral Presentation Award, 2015
- ASSCR Image Competition Award and display in the Regenerative Medicine Exhibit (Stem Cell Stories; Canberra and Adelaide), 2013 - 2014
- ASN Top Oral Abstract for Trainees, 2013
- National Stem Cell Foundation of Australia Conference Education Award, 2013
- Centenary Institute Microscopy Image Prize, 2009
- Australian Postgraduate Award PhD scholarship, 2007
- NANO Student Research Award/Scholarship, 2007
Generating and characterising kidney progenitor cell types derived from direct transcriptional reprogramming and directed differentiation
- Direct transcriptional reprogramming to nephron progenitors
- Improving the growth and maturation of kidney organoids
- Characterising and improving nephron progenitors in kidney organoids derived from iPSC reporter lines
Vanslambrouck JM, Woodard LE, Suhaimi N, Williams FM, Howden SE, Wilson S, Er PX, Li J, Wilson MH, Little MH. Direct reprogramming to human nephron progenitor-like cells using inducible piggyBac transposon expression of SNAI2-EYA1-SIX1. Kidney International (In Press, November 2018).
Van den Berg CW, Avramut CM, Wiersma LE, Van den Berg BM, Leuning DG, Lievers E, Koning M, Vanslambrouck JM, Howden SE, Koster AJ, Takasato M, Little MH, Rabelink TJ. (2018) Renal Subcapsular Transplantation of PSC-Derived Kidney Organoids Induces Neo-vasculogenesis and Significant Glomerular and Tubular Maturation In Vivo. Stem Cell Reports, 10(3), 751-765.
Lefevre J, Chiu, HS, Combes AN, Vanslambrouck JM, Hamilton ND, Little MH. (2017) Self-organisation in the embryonic kidney is driven via selective adhesion of ureteric epithelial cells. Development, 144(6), 1087-1096.
Vanslambrouck JM, Little MH. (2015) Direct transcriptional reprogramming to nephron progenitors. Curr Opin Genet Dev, 10, 10-16.
Takasato M, Er PX, Becroft M, Vanslambrouck JM, Stanley EG, Elefanty AG, Little MH. (2014) Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organising kidney. Nat Cell Biol, 16, 118-26.
Takasato M, Vanslambrouck JM, Little MH. (2014) Reprogramming Somatic Cells to a Kidney Fate. Semin Nephrol, 34, 462-80.
+Hendry CE, +Vanslambrouck JM, Ineson J, Suhaimi N, Takasato M, Rae F, Little MH. (2013) Direct transcriptional reprogramming of adult cells to embryonic nephron progenitors. J Am Soc Nephrol, 24, 1424-34. (+co-first authorship)
Vanslambrouck J, Li J, Little MH. (2011) The renal papilla: an enigma in damage and repair. J Am Soc Nephrol, 22, 2145-7.
Bröer A, Juelich T, Vanslambrouck JM, Tietze N, Soloman PS, Holst J, Bailey CG, Rasko JE, Bröer S. (2011) Impaired nutrient signalling and body weight control in a Na+ neutral amino acid cotransporter (Slc6a19)-deficient mouse. J Biol Chem, 286, 26638-51.
Bailey CG, Ryan RM, Thoeng AD, Ng C, King K, Vanslambrouck JM, Auray-Blais C, Vandenberg RJ, Bröer S, Rasko JEJ. (2011) Loss-of-function mutations in the glutamate transporter SLC1A1 cause human dicarboxylic aminoaciduria. J Clin Invest, 121, 446-53.
Einecke G, Kayser D, Vanslambrouck JM, Sis B, Reeve J, Mengel M, Famulski KS, Bailey CG, Rasko J.E., Halloran P.F. (2010) Loss of solute carriers in T cell-mediated rejection in mouse and human kidneys: an active epithelial injury-repair response. Am J Transplant, 10, 2241-51.
Vanslambrouck JM, Bröer A, Thavayogarajah T, Holst J, Bailey CG, Bröer S, Rasko JE. (2010) Molecular mechanisms of amino acid transport in the developing kidney. Biochem J, 428, 397-407.
Kowalczuk S, Bröer A, Tietze N, Vanslambrouck JM, Rasko JE, Broer S. (2008) A protein complex in the brush-border membrane explains a Hartnup disorder allele. FASEB J, 22, 2880-7.
Bröer S, Bailey CG, Kowalczuk S, Ng C, Vanslambrouck JM, Rodgers H, Auray-Blais C, Cavanaugh JA, Broer A, Rasko JE. (2008) Iminoglycinuria and hyperglycinuria are discrete human phenotypes resulting from complex mutations in proline and glycine transporters. J Clin Invest, 118, 3881-3892.
Gardiner J, Barton D, Vanslambrouck JM., Braet F, Hall D, Marc J, Overall R. (2008) Defects in tongue papillae and taste sensation indicate a problem with neurotrophic support in various neurological diseases. Neuroscientist, 14, 240-50.
2016 - 2020: NIH/NIDDK DK107344-01: ReBuilding a Kidney
2012 - 2016: NHMRC APP1041275: Reprogramming to nephron progenitors