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Professor Ed Stanley
Ed Stanley completed his PhD at the Ludwig Institute for Cancer Research in Melbourne, working on hematopoietic growth factors and gene targeting. Following his PhD, he undertook post-doctoral studies in Developmental Biology at the National Institute for Medical Research, Mill Hill, London. On his return to Australia, Ed joined Richard Harvey's cardiac developmental biology laboratory at the Walter and Eliza Hall Institute, Melbourne.
In 2002, together with colleague Professor Andrew Elefanty, Ed established The Embryonic Stem Cell Differentiation Laboratory at Monash University. This laboratory focused on human embryonic stem cell (ESC) differentiation along mesodermal (blood, endothelium and heart) and endodermal (pancreas) lineages. This group developed novel methods for genetic modification of pluripotent stem cells and serum free differentiation protocols.
In 2012, Professor Stanley to moved the Murdoch Childrens Research Institute, where he currently heads the Immune Development Laboratory. He is an NHMRC senior research fellow.
- Professor, Department of Paediatrics, University of Melbourne
- Adjunct Professor,Department of Anatomy and Developmental Biology, Monash University
- 1992-93: Human Frontiers in Science Program Organization long-term fellowship (London)
- 1993- 1996: C.J. Martin Fellowship, National Institute for Medical Research (London, UK)
- 1996- 1998: C.J. Martin Fellowship, Walter & Eliza Hall Institute (Australia)
- 2010- 2014: NHMRC Research Fellowship (SRFA)
- 2015- 2020: NHMRC Research Fellowship (SRFA)
Professor Stanley's current work uses stem cell differentiation systems to understand human development, to generate tools for drug discovery, and to provide a source of cells for future medical applications. His group has a special interest in stem cell derived immune cells and insulin producing beta cells. These two areas intersect in current research aimed at generating in vitro models of type 1 diabetes, an autoimmune condition in which the body's immune system attacks and destroys pancreatic insulin producing cells.
- Analysis of stem cell derived beta cells
- Making Immune cells in the laboratory
- Stem cell models of human development
- Genetic manipulation of pluripotent stem cells
Multipotent RAG1+ progenitors emerge directly from haemogenic endothelium in human pluripotent stem cell-derived haematopoietic organoids. Motazedian A et al. Nat Cell Biol. 2020 Jan;22(1):60-73.
Generation of a SOX9-tdTomato reporter human iPSC line, MCRIi001-A-2, using CRISPR/Cas9 editing. Nur Patria et al. Stem Cell Res. 2019 Dec 19;42:101689.
The role of cardiac transcription factor NKX2-5 in regulating the human cardiac miRNAome. Arasaratnam D, et al. Sci Rep. 2019 Nov 4;9(1):15928. doi: 10.1038/s41598-019-52280-9. Erratum in: Sci Rep. 2019 Dec 27;9(1):20269.
Induced pluripotent stem cell macrophages present antigen to proinsulin-specific T cell receptors from donor-matched islet-infiltrating T cells in type 1 diabetes. Joshi K, et al. Diabetologia. 2019 Dec;62(12):2245-2251.
The use of simultaneous reprogramming and gene correction to generate an osteogenesis imperfecta patient COL1A1 c. 3936 G>T iPSC line and an isogenic control iPSC line. Howden S, et al. Stem Cell Res. 2019 Jul;38:101453.
Generation of a heterozygous COL1A1 (c.3969_3970insT) osteogenesis imperfecta mutation human iPSC line, MCRIi001-A-1, using CRISPR/Cas9 editing. Hosseini Far H, et al. Stem Cell Res. 2019 May;37:101449.
Generation of iPSC lines from peripheral blood mononuclear cells from 5 healthy adults. Vlahos K, et al.. Stem Cell Res. 2019 Jan;34:101380.
Assessment of established techniques to determine developmental and malignant potential of human pluripotent stem cells. International Stem Cell Initiative. Nat Commun. 2018 May 15;9(1):1925.
NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network. Anderson DJ, et al. Nat Commun. 2018 Apr 10;9(1):1373.
Generation of RAB39B knockout isogenic human embryonic stem cell lines to model RAB39B-mediated Parkinson's disease. Gao Y, et al. Stem Cell Res. 2018 Apr;28:161-164.
WNT9A Is a Conserved Regulator of Hematopoietic Stem and Progenitor Cell Development. Richter J, et al. Genes (Basel). 2018 Jan 29;9(2).
Long-Term Maintenance of Human Pluripotent Stem Cells on cRGDfK-Presenting Synthetic Surfaces. Lambshead JW, et al.Sci Rep. 2018 Jan 15;8(1):701.
Regulatory networks specifying cortical interneurons from human embryonic stem cells reveal roles for CHD2 in interneuron development. Meganathan K, et al. Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11180-E11189.
Overcoming Monocarboxylate Transporter 8 (MCT8)-Deficiency to Promote Human Oligodendrocyte Differentiation and Myelination. Lee JY, et al. EBioMedicine. 2017 Nov;25:122-135.
Inhibition of DYRK1A disrupts neural lineage specificationin human pluripotent stem cells. Bellmaine SF, et al. Elife. 2017 Sep 8;6. pii: e24502.
RUNX1c Regulates Hematopoietic Differentiation of Human Pluripotent Stem Cells Possibly in Cooperation with Proinflammatory Signaling. Navarro-Montero O, et al. Stem Cells. 2017 Nov;35(11):2253-2266.
Efficiently Specified Ventral Midbrain Dopamine Neurons from Human Pluripotent Stem Cells Under Xeno-Free Conditions Restore Motor Deficits in Parkinsonian Rodents. Niclis JC, et al. Stem Cells Transl Med. 2017 Mar;6(3):937-948.
Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system. Workman MJ. et al. Nat Med. 2017 Jan;23(1):49-59.
Differentiation of human embryonic stem cells to HOXA+ hemogenic vasculature that resembles the aorta-gonad-mesonephros. Ng ES, et al. Nat Biotechnol. 2016 Nov;34(11):1168-1179.
GAPTrap: A Simple Expression System for Pluripotent Stem Cells and Their Derivatives. Kao T, et al. Stem Cell Reports. 2016 Sep 13;7(3):518-526.
A Cas9 Variant for Efficient Generation of Indel-Free Knockin or Gene-Corrected Human Pluripotent Stem Cells.. Howden SE, et al. Stem Cell Reports. 2016 Sep 13;7(3):508-517..
Spatio-temporal re-organization of replication foci accompanies replication domain consolidation during human pluripotent stem cell lineage specification. Wilson KA, et al. Cell Cycle. 2016 Sep 16;15(18):2464-75.
Enforced Expression of HOXB4 in Human Embryonic Stem Cells Enhances the Production of Hematopoietic Progenitors but Has No Effect on the Maturation of Red Blood Cells.s. Jackson M, et al. Stem Cells Transl Med. 2016 Aug;5(8):981-90.
- National Health & Medical Research Council (Australia)
- Juvenille Diabetes Reserach Foundation
- Children's Cancer Foundation