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Trial seeking kids allergic to egg to test pioneering allergy treatment

Institute News
Friday, June 12, 2020 - 10:15am

A trial led by the Murdoch Children’s Research Institute (MCRI) is recruiting 80 children and adolescents allergic to egg to test a pioneering new approach to food allergies.
  
MCRI Professor Mimi Tang is developing a probiotic and peanut immunotherapy treatment, which has shown long-lasting effects against peanut allergy. Prof Tang is now extending that treatment approach to egg, a major cause of childhood allergy worldwide.

She is calling on families with children aged five to 17 years who are allergic to hen eggs to take part in the new PEAT trial.

“Food allergies affect around 5-6 per cent of all children and 10 per cent of infants,” Professor Tang said. “And egg allergy is one of the most common food allergies in childhood, affecting almost 9 per cent of babies in Australia and up to 2.5 per cent of children worldwide. 

“We previously thought that most children with egg allergy would develop tolerance by school age, but recent studies show that egg allergy can persist in a significant number of children until adolescence.” 

Professor Tang said most people with egg allergy have no choice but to avoid all foods containing eggs. 

“Because eggs are a common cooking ingredient, accidental ingestion is common, causing frequent and sometimes life-threatening reactions,” she said. 

“To live with food allergy reduces your quality of life. Every day you need to be vigilant against the threat of a serious reaction. Deaths are very rare, but patients and families are understandably fearful of this possibility.” 

In a 2015 clinical trial testing the probiotic and peanut oral immunotherapy (PPOIT) treatment, participants were given a probiotic together with peanut protein in increasing amounts once daily for 18 months. More than 80 per cent of children who received the PPOIT treatment were able to tolerate peanuts at the end of the trial and the majority were still tolerating peanut four years on. 

“If we can show that the probiotic food immunotherapy approach is effective in treating egg allergies as well, this will mean that we could perhaps extend treatment to other food allergies,” Professor Tang said. 

“We are fortunate to have received funding from Australia’s National Health and Medical Research Council to conduct a randomised controlled trial to test the effectiveness of a probiotic egg oral immunotherapy for the treatment of egg allergy.” 

Professor Tang is running this egg trial in conjunction with the National University Hospital in Singapore.

Recorded incidences of food allergy have risen dramatically in recent decades with 250 million people worldwide now suffering a food allergy.

Hospital admissions for severe allergic reactions have doubled over the last decade in Australia, US and UK. In Australia, admissions for serious food allergy reactions in children aged zero to four years have jumped to an even greater extent, increasing five-fold over the same period. 

For this study, the children will be randomly allocated into one of two groups. Half the children will go into an active group (probiotic and egg oral immunotherapy) and half will go into a placebo group. At home the child will take a dose of probiotic (or placebo) and a dose of egg powder (or placebo) once a day for a total of 18 months. 

Researchers from James Cook University will also contribute to the study.

To enrol your child in the PEAT trial please email egg.study@mcri.edu.au or for more information visit www.mcri.edu.au/research/projects/peat-trial

*The content of this communication is the sole responsibility of MCRI and does not reflect the views of the NHMRC.

Available for interview: 
Professor Mimi Tang
Study participant 

Media Contact: 

Bridie Byrne
MCRI communications specialist
+613 9936 6211/ 0403 664 416 
bridie.byrne@mcri.edu.au
 
About MCRI

The Murdoch Children's Research Institute (MCRI) is the largest child health research institute in Australia committed to making discoveries and developing treatments to improve child and adolescent health in Australia and around the world. They are pioneering new treatments, trialling better vaccines and improving ways of diagnosing and helping sick babies, children and adolescents. It is one of the only research institutes in Australia to offer genetic testing to find answers for families of children with previously undiagnosed conditions.

Funding
The study is funded by National Health and Medical Research Council Project Grant (APP1144965).