Generating bioengineered heart valves to treat childhood heart disease
- Project status: Active
Research area: Stem Cell Medicine > Heart Regeneration
Current valve prosthetics used for surgery are made from animal tissue and are not compatible with the small hearts of children.
This study seeks to benchmark lab-grown induced pluripotent stem cell-derived bioengineered heart valve tissue with current prosthetics, with the aim to create a better option for heart valve replacement.
Image: Bioengineered heart valve tissue.
Credit: Jessica Durrant-Whyte, Heart Regeneration.
This study seeks to benchmark lab-grown induced pluripotent stem cell-derived bioengineered heart valve tissue with current prosthetics, with the aim to create a better option for heart valve replacement.
Image: Bioengineered heart valve tissue.
This study seeks to benchmark lab-grown induced pluripotent stem cell-derived bioengineered heart valve tissue with current prosthetics, with the aim to create a better option for heart valve replacement.
Image: Bioengineered heart valve tissue.
Credit: Jessica Durrant-Whyte, Heart Regeneration.
Purpose of research
Current valve prosthetics used for surgery are made from animal tissue and are not compatible with the small hearts of children.
Study details
Led by Dr Holly Voges, the team have engineered a novel stem cell-derived tissue for the fabrication of precision-made valve bio-prosthetics. They are now benchmarking their current bio-prosthetics prototypes against native human heart valve tissue, using single-cell RNA sequencing and histology.
Ongoing work is focused on building dynamic culture platforms to mimic the environment of the beating heart.
Team photo from left: Adriano Morandini, Jessica Durrant-Whyte, Holly Voges, Serene Yeow, Adam Piers. All team members in the image have given consent to use it on the website. Photo owned by MCRI.
Contact us
Dr Holly Voges, Team Leader
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