PEAChY-M Study

Research area: Clinical Sciences > Emergency research | Status: Active

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PEAChY-M: Pharmacological Emergency Management of Agitation in Children and Young People - A Randomised Controlled Trial of IntraMuscular Medication

This clinical drug trial aims to determine whether intramuscular (IM) olanzapine is more effective than IM droperidol for the management of acute severe behavioural disturbance (ASBD) in children and adolescents presenting to Emergency Departments (EDs).

This clinical drug trial aims to determine whether intramuscular (IM) olanzapine is more effective than IM droperidol for the management of acute severe behavioural disturbance (ASBD) in children and adolescents presenting to Emergency Departments (EDs).

This clinical drug trial aims to determine whether intramuscular (IM) olanzapine is more effective than IM droperidol for the management of acute severe behavioural disturbance (ASBD) in children and adolescents presenting to Emergency Departments (EDs).

Overview

PEAChY-M is a clinical drug trial. A total of 348 children aged nine (9) years to less than 18 years of age with acute severe behavioural disturbance (ASBD) in 10 paediatric Emergency Departments (EDs) around Australia will be enrolled.

Purpose

A number of randomised controlled trials (RCTs) investigating the pharmacological management of ASBD have been undertaken in the adult population. However, there is a dearth of evidence in the paediatric population – no RCTs or systematic reviews have been undertaken. As a result, with paediatric presentations of ASBD increasing every year, the findings from the adult RCTs have been extrapolated to this group. This is concerning, as the causes of ASBD in children are notably different than in adults. The adult medications currently being used in children are also likely to vary in their efficacy and side effect profiles within the paediatric population.

Additionally, ASBD presentations have significant impacts on ED resources. However, the degree of resource use and the associated costs incurred have not been studied in the paediatric ASBD setting.

The PEAChY-M study aims to provide the Australasian clinical community with clear information on the most effective intramuscular medication for use in paediatric ASBD, as well as data related to healthcare resource use and costs for paediatric ASBD presentations to EDs.

Please note: This project is not open for participation by the general public.

Frequently asked questions

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