PEAChY-O Study

Research area: Clinical Sciences > Emergency | Status: Active

young person

Pharmacological Emergency Management of Agitation in Children and Young People A Randomised Controlled Trial of Oral Medication (PEAChY-O)

The goal of PEAChY-O is to determine whether oral olanzapine is more effective than oral diazepam for the management of acute severe behavioural disturbance (ASBD) in children and adolescents presenting to Emergency Departments (EDs).

The goal of PEAChY-O is to determine whether oral olanzapine is more effective than oral diazepam for the management of acute severe behavioural disturbance (ASBD) in children and adolescents presenting to Emergency Departments (EDs).

The goal of PEAChY-O is to determine whether oral olanzapine is more effective than oral diazepam for the management of acute severe behavioural disturbance (ASBD) in children and adolescents presenting to Emergency Departments (EDs).

Overview

The goal of PEAChY-O is to determine whether oral olanzapine is more effective than oral diazepam for the management of acute severe behavioural disturbance (ASBD) in children and adolescents presenting to Emergency Departments (EDs). Both medications are currently commonly used to manage ASBD, but we do not yet know which is more effective for the paediatric population.

PEAChY-O is a pragmatic clinical trial, so the study conditions mimic “real life” as much as possible with simple inclusion criteria and exclusion criteria, and very few elements of care that are different to current Australia-wide practice guidelines. PEAChY-O will enrol 348 children with ASBD in 7 paediatric EDs around Australia.

Study Population

PEAChY-O will enrol children from 9 years to less than 18 years of age with ASBD during an ED visit to a study site. Children will be considered having ASBD by the ED doctor and will subsequently be offered one of the study medications if all other attempts to calm the child are unsuccessful. The study will include children who are previously healthy, as well as children with known mental health problems.

Research team

Principal Investigator
Dr Elyssia Bourke (PhD Candidate)

Chief Investigator
Professor Franz Babl

Study Coordinator
Kate Klein

child in hospital

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