LifeCourse
Leveraging longitudinal cohorts to provide a healthy start to life
The Melbourne Children’s LifeCourse Initiative brings together an impressive collection of longitudinal cohort studies from across the Melbourne Children’s Campus.
We aim to harness the rich and robust data collected across 24 core longitudinal cohort studies, to understand some of the most complex health and wellbeing issues facing young people today.
The Melbourne Children’s LifeCourse Initiative brings together an impressive collection of longitudinal cohort studies from across the Melbourne Children’s Campus.
We aim to harness the rich and robust data collected across 24 core longitudinal...
The Melbourne Children’s LifeCourse Initiative brings together an impressive collection of longitudinal cohort studies from across the Melbourne Children’s Campus.
We aim to harness the rich and robust data collected across 24 core longitudinal cohort studies, to understand some of the most complex health and wellbeing issues facing young people today.
Our LifeCourse cohorts capture the health and development of over 118,000 participants, from pre-conception through to adulthood (including two intergenerational cohorts), dating back to 1983.
These cohorts collectively hold millions of data points and are supplemented by exceptional data in biosamples, imaging, and linkage to administrative datasets.
This unparalleled data resource has the power to answer some of the most pressing questions in child and adolescent health and wellbeing that could not be answered by one study on its own.
We support our cohort custodians and potential data users, by equipping them with the tools, collaborations and access to produce more meaningful and robust research.
We also promote a thriving community of practice for longitudinal data custodians and researchers, facilitating the sharing of knowledge and novel approaches and maximising the impact created by our researchers.
Launched in 2013, the Melbourne Children’s LifeCourse Initiative brings together longitudinal cohort studies from members of the Melbourne Children’s Campus (Murdoch Children’s Research Institute, The Royal Melbourne Children’s Hospital, and the University of Melbourne).
This platform has allowed a rich and dynamic resource to emerge, that is unmatched in its power and possibility and has already shaped meaningful policy and clinical care nationally and internationally.
LifeCourse strives to make cohort data findable, browsable and accessible.
Group Leaders
Group Members
Our research focus
- Mental Health
- Cardiometabolic Health
- Immune Function
- COVID-19 research
Visit our website for more information on LifeCourse research.
Funding
LifeCourse was established with funding from The Royal Children’s Hospital Foundation.
Visit our website for information on LifeCourse funding opportunities
Collaborations
LifeCourse is jointly supported by the Melbourne Children’s Campus partners:
- Murdoch Children's Research Institute (MCRI)
- The Royal Children’s Hospital (RCH)
- The University of Melbourne (Department of Paediatrics)
Featured publications
O'Connor M, Olsson CA, Lange K, Downes M, Moreno-Betancur M, Mundy L, Viner RM, Goldfeld S, Patton G, Sawyer SM, Hope S. Progressing "Positive Epidemiology": A Cross-national Analysis of Adolescents' Positive Mental Health and Outcomes During the COVID-19 Pandemic. Epidemiology. 2025 Jan 1;36(1):28-39. doi: 10.1097/EDE.0000000000001798. Epub 2024 Oct 22. PMID: 39435893.
O'Connor M, Knight K, O'Connor E, Hughes EK, Goldfeld S, Olsson CA. An Australian perspective on opportunities to innovate and evolve impact in cohort studies: a reply to 'Re-considering "impact" for longitudinal social science research: towards more scientific approaches to theorising and measuring the influence of cohort studies' by Bridger Staatz et al. Longit Life Course Stud. 2025 Jun 2;16(3):407-417. doi: 10.1332/17579597Y2025D000000046. PMID: 40557596.
Downes M, O'Connor M, Olsson CA, Burgner D, Goldfeld S, Spry EA, Patton G, Moreno-Betancur M. Causal inference in multi-cohort studies using the target trial framework to identify and minimize sources of bias. Am J Epidemiol. 2025 Sep 3;194(9):2685-2697. doi: 10.1093/aje/kwae405. PMID: 39445353; PMCID: PMC12409135.
O'Connor M, Spry E, Patton G, Moreno-Betancur M, Arnup S, Downes M, Goldfeld S, Burgner D, Olsson CA. Better together: Advancing life course research through multi-cohort analytic approaches. Adv Life Course Res. 2022 Sep;53:100499. doi: 10.1016/j.alcr.2022.100499. Epub 2022 Jul 18. PMID: 36652217.
O'Connor M, Moreno-Betancur M, Goldfeld S, Wake M, Patton G, Dwyer T, Tang MLK, Saffery R, Craig JM, Loke J, Burgner D, Olsson CA; LifeCourse Cohort Investigators. Data Resource Profile: Melbourne Children's LifeCourse initiative (LifeCourse). Int J Epidemiol. 2022 Oct 13;51(5):e229-e244. doi: 10.1093/ije/dyac086. PMID: 35536352; PMCID: PMC9557929.
For more informatoin on LifeCourse, please reach out.
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