BRACE Trial

Research area: Infection, Immunity and Global HealthInfectious Diseases | Status: Active

This Australian-led study is the world’s largest trial on the off-target effects of Bacille Calmette-Guérin (BCG) vaccine.

The BRACE trial is investigating whether BCG vaccine reduces the incidence of symptomatic and severe COVID-19, as well as other respiratory illnesses and allergic diseases.

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The BRACE trial is investigating whether BCG vaccine reduces the incidence of symptomatic and severe COVID-19, as well as other respiratory illnesses and allergic diseases.

Data and Sample Requests

Participant FAQs                  

PhD...

The BRACE trial is investigating whether BCG vaccine reduces the incidence of symptomatic and severe COVID-19, as well as other respiratory illnesses and allergic diseases.

Data and Sample Requests

Participant FAQs                  

PhD Opportunities            

Overview

As well as preventing severe tuberculosis (TB) in children, the BCG vaccine has off-target (non-specific or immunomodulatory) effects which may enhance protection against other infections. That’s why this multi-centre, randomised controlled clinical trial is working to determine:

  • Whether BCG vaccine reduces the incidence of symptomatic and severe COVID-19
  • If BCG vaccine reduces the impact of other respiratory illnesses and allergic diseases
  • The immunological mechanisms that underlie BCG’s off-target effects, COVID-19 severity and risks
  • The safety profile of BCG vaccination and revaccination in adults
  • If BCG alters the acquisition of latent TB in healthcare workers
  • Biomarkers predictive of COVID-19 risk, severity and vaccine efficacy 

Trial data

So far, the trial has generated:

Trial Symptom Tracker app entries:

355,000

Telephonista entries:

190,000

BRACE blood samples:

25,000


BCOS blood samples:

1,900

Clinic visits:

26,000

Surveys sent:

23,000

 

A cutting-edge study of BCG vaccines off-target effects 

icon 100yo v3>6800
healthcare workers

icon 100yo v336
study sites

icon 100yo v35
countries

 

icon 100yo v3 >400
researchers & staff

icon 100yo v3 >335K
app check-ins

icon 100yo v3 100
year-old vaccine

 

Contact us

The BRACE trial
Murdoch Children's Research Institute
The Royal Children's Hospital
50 Flemington Road
Parkville VIC 3052
Australia

Email: 

Professor Nigel Curtis in Murdoch Children's Research Institute Annual Showcase 2020.

Can a 100-year-old vaccine protect healthcare workers against COVID-19?

Professor Nigel Curtis is a paediatric infectious diseases physician and clinician scientist and leader of the Infectious Diseases Research Group at the Murdoch Children's Research Institute.

See more BRACE videos on YouTube.

 

Can a 100-year-old vaccine protect healthcare workers against COVID-19?

Professor Nigel Curtis is a paediatric infectious diseases physician and clinician scientist and leader of the Infectious Diseases Research Group at the Murdoch Children's...

Can a 100-year-old vaccine protect healthcare workers against COVID-19?

Professor Nigel Curtis is a paediatric infectious diseases physician and clinician scientist and leader of the Infectious Diseases Research Group at the Murdoch Children's Research Institute.

See more BRACE videos on YouTube.

 

Professor Nigel Curtis

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